DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and CES1

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001020366.1	Gene:	CES1 / 1066	HGNCID:	1863	Length:	568	Species:	Homo sapiens

Alignment Length:	716	Identity:	194/716 - (27%)
Similarity:	293/716 - (40%)	Gaps:	208/716 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 LRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVP 74
            ||..:|.|:        .||.|  :.|......:|.|.:|::.|..:.|:.  |.:.|.:|||:|
Human     3 LRAFILATL--------SASAA--WAGHPSSPPVVDTVHGKVLGKFVSLEG--FAQPVAIFLGIP 55

  Fly    75 YATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQ--RLPNIQNE--TAALEKMPKGRLEYLKRL 135
            :|.||....||:|.:...||..::.:..|.|:|.|  :...:.:|  |...|.:|      ||
Human    56 FAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENIP------LK-- 112

  Fly   136 LPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLN 200
                  .||||||||:::|.:. ..:.:|||:|:|||......:.:.|||..||::..|||||:.
Human   113 ------LSEDCLYLNIYTPADL-TKKNRLPVMVWIHGGGLMVGAASTYDGLALAAHENVVVVTIQ 170

  Fly   201 YRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYL 265
            |||||.||.:....   |:| .|:|.:||:|||.|:|.||..|||:|.|||:.|...|...::.|
Human   171 YRLGIWGFFSTGDE---HSR-GNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVL 231

  Fly   266 MTSPTMVRGLFHRAILMSGSAYSSWALVE--DPVLFAIKLAKEVNC-TIPDDINRHHEQIVDCLR 327
            :.|| :.:.||||||..||.|.:| .||:  |....|.::|....| |....:      :|.|||
Human   232 VLSP-LAKNLFHRAISESGVALTS-VLVKKGDVKPLAEQIAITAGCKTTTSAV------MVHCLR 288

  Fly   328 DVPLEDLYLADIQAPNFLT------------SFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSAD 380
            ....|:|....::. .||:            ..|..:||:             |:.:......|:
Human   289 QKTEEELLETTLKM-KFLSLDLQGDPRESQPLLGTVIDGM-------------LLLKTPEELQAE 339

  Fly   381 SGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIW---- 441
            ..|.:                                          ...:.|:...|..|
Human   340 RNFHT------------------------------------------VPYMVGINKQEFGWLIPM 362

  Fly   442 RFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYTD-----WDRTSQHPINTRDTA 501
            :..::.:.   ||:...|...:.:..  :|.|..|...::.|.|:     .|.|    :..:|..
Human   363 QLMSYPLS---EGQLDQKTAMSLLWK--SYPLVCIAKELIPEATEKYLGGTDDT----VKKKDLF 418

  Fly   502 VAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDY-- 564
            :..::|..|..|.|    |:|.|       ...||:|                  .|.|.|.|
Human   419 LDLIADVMFGVPSV----IVARN-------HRDAGAP------------------TYMYEFQYRP 454

  Fly   565 --------QTKDGDYPQRMGTVHGEDLPYIFGAP-LVDGFSHFPQNYTKSETALSEAVMIFWTNF 620
                    :|..||        ||::|..:|||| |.:|.|       :.|..||:.||.||.||
Human   455 SFSSDMKPKTVIGD--------HGDELFSVFGAPFLKEGAS-------EEEIRLSKMVMKFWANF 504

  Fly   621 ARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQK--YLEIGMKPRIKNHFRAHQLSIWLR 683
            ||.||||     ...||           .|..|   :||  ||:||...:.....:..:::.|..
Human   505 ARNGNPN-----GEGLP-----------HWPEY---NQKEGYLQIGANTQAAQKLKDKEVAFWTN 550

  Fly   684 L 684
            |
Human   551 L 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	184/678 (27%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	184/679 (27%)
CES1	NP_001020366.1	Aes	<122..>240	CDD:223730	50/123 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810