DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and CEL

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens

Alignment Length:	738	Identity:	197/738 - (26%)
Similarity:	289/738 - (39%)	Gaps:	253/738 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGESQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLR 65
            ||..||::|            .:.|..|    :...|:||  .|.|..|.:.|:...|....  .
Human     1 MGRLQLVVL------------GLTCCWA----VASAAKLG--AVYTEGGFVEGVNKKLGLLG--D 45

  Fly    66 SVEVFLGVPYATPPTKQNRFSPTRA---PAP---WDGIRISDKYSPVCPQRLPNIQNETAALEKM 124
            ||::|.|:|:|         :||:|   |.|   |.|...:..:...|.|.... |:.|..
Human    46 SVDIFKGIPFA---------APTKALENPQPHPGWQGTLKAKNFKKRCLQATIT-QDSTYG---- 96

  Fly   125 PKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNP------- 182
                              .|||||||::.|.......:.|||:::|:|.:|...||:.
Human    97 ------------------DEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNY 143

  Fly   183 -YDGSVLASYGEVVVVTLNYRLGILGFL---NAN-PNPHAHARVANYGLMDQMAALHWIQQNIQK 242
             |||..:|:.|.|:|||.|||:|.||||   :|| |        .||||.||..|:.|:::||..
Human   144 LYDGEEIATRGNVIVVTFNYRVGPLGFLSTGDANLP--------GNYGLRDQHMAIAWVKRNIAA 200

  Fly   243 FGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEV 307
            ||||||::||.|...|.|.::....|| ..:||..|||..||.|.|.|.:.::|:.:|.|:|::|
Human   201 FGGDPNNITLFGESAGGASVSLQTLSP-YNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKV 264

  Fly   308 NCTIPDDINRHHEQIVDCLR-----------DVPLEDLYLADIQAPNF-LTSFGPSVDGVVIRPG 360
            .|.:.|     ..::..||:           .||     ||.::.|.. ...|.|.:||..|...
Human   265 GCPVGD-----AARMAQCLKVTDPRALTLAYKVP-----LAGLEYPMLHYVGFVPVIDGDFIPAD 319

  Fly   361 HSNL-----DIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAG 420
            ..||     |||.:                                                 ||
Human   320 PINLYANAADIDYI-------------------------------------------------AG 335

  Fly   421 TMNMGGHYDVLFGVVTGESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYHLNEIFYTIVNEYT 485
            |.||.||.              |::.|:....:|.::              ...|.||.:|:|:|
Human   336 TNNMDGHI--------------FASIDMPAINKGNKK--------------VTEEDFYKLVSEFT 372

  Fly   486 -----------------DWDRTSQHPI--NTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSS 531
                             .|   :|.|.  |.:.|.|...:|..|:.|...|   ||.:.
Human   373 ITKGLRGAKTTFDVYTESW---AQDPSQENKKKTVVDFETDVLFLVPTEIA---LAQHR------ 425

  Fly   532 SSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFS 596
                    |||          .|.:.|.|:|.:.::...||:.:|..|.:|:.|:||.|...
Human   426 --------ANA----------KSAKTYAYLFSHPSRMPVYPKWVGADHADDIQYVFGKPFAT--- 469

  Fly   597 HFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYL 661
              |..|...:..:|:|::.:|||||:||:||   ..||::|..          ||.|...:..||
Human   470 --PTGYRPQDRTVSKAMIAYWTNFAKTGDPN---MGDSAVPTH----------WEPYTTENSGYL 519

  Fly   662 EIGMK---PRIKNHFRAHQLSIW 681
            ||..|   ..:|...|.:.|..|
Human   520 EITKKMGSSSMKRSLRTNFLRYW 542

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	186/694 (27%)
CEL	NP_001798.3	Heparin-binding	21..121		35/135 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910