DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Nlg4 and Ces1d

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_444430.2	Gene:	Ces1d / 104158	MGIID:	2148202	Length:	565	Species:	Mus musculus

Alignment Length:	699	Identity:	200/699 - (28%)
Similarity:	287/699 - (41%)	Gaps:	181/699 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 LLPTVLIS------WMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLG 72
            |.|.:.:|      |.:.:.....:..||..||      :|..|.|         |.:.|.||||
Mouse     3 LYPLIWLSLAACTAWGYPSSPPVVNTVKGKVLG------KYVNLEG---------FTQPVAVFLG 52

  Fly    73 VPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLP 137
            ||:|.||....||:|.:...||..::.:..|.|:|.|.....|    .|.::...|.|.:.  |.
Mouse    53 VPFAKPPLGSLRFAPPQPAEPWSFVKNTTSYPPMCSQDAVGGQ----VLSELFTNRKENIP--LQ 111

  Fly   138 FLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYR 202
            |    ||||||||:::|.:...| .:|||:|:|||........:.|||..|:::..|||||:.||
Mouse   112 F----SEDCLYLNIYTPADLTKN-SRLPVMVWIHGGGLVVGGASTYDGLALSAHENVVVVTIQYR 171

  Fly   203 LGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMT 267
            |||.||.:....   |:| .|:|.:||:|||.|:|.||..|||:|.|||:.|...|...::.|:.
Mouse   172 LGIWGFFSTGDE---HSR-GNWGHLDQVAALRWVQDNIANFGGNPGSVTIFGESAGGFSVSVLVL 232

  Fly   268 SPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNC-TIPDDINRHHEQIVDCLR---- 327
            || :.:.||||||..||.:.::..:..|....|..:|....| |....:      :|.|||
Mouse   233 SP-LAKNLFHRAISESGVSLTAALITTDVKPIAGLVATLSGCKTTTSAV------MVHCLRQKTE 290

  Fly   328 DVPLE-----DLYLADIQA-PNFLTSFGPSV-DGVVIRPGHSNLDIDDLMARNSRRSSADSGFQS 385
            |..||     :|:..|:.. |.....|.|:| ||||:....     ::::|..|        |.:
Mouse   291 DELLETSLKLNLFKLDLLGNPKESYPFLPTVIDGVVLPKAP-----EEILAEKS--------FST 342

  Fly   386 SAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQN 450
            ..                         |.  .|......|.....|.|....
Mouse   343 VP-------------------------YI--VGINKQEFGWIIPTLMGYPLA------------- 367

  Fly   451 GFEGERRDKIIRTYVRNAY-NYHLNEIFYTIVNEY----TDWDRTSQHPINTRDTAVAALSDAQF 510
              ||:...|...:.:..:| ...::|....:|.|.    || |.|.:     :|.....::|..|
Mouse   368 --EGKLDQKTANSLLWKSYPTLKISENMIPVVAEKYLGGTD-DLTKK-----KDLFQDLMADVVF 424

  Fly   511 VAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTK--DGDYPQ 573
            ..|.|            .||.|.      .:|.|||           |.|.|:|:..  ....|:
Mouse   425 GVPSV------------IVSRSH------RDAGAST-----------YMYEFEYRPSFVSAMRPK 460

  Fly   574 RMGTVHGEDLPYIFGAP-LVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLP 637
            .:...||:::..:||:| |.||.|       :.||.||:.||.||.||||.||||     ...||
Mouse   461 AVIGDHGDEIFSVFGSPFLKDGAS-------EEETNLSKMVMKFWANFARNGNPN-----GGGLP 513

  Fly   638 VSKERNRFRSITWENYDPLHQK--YLEIGMKPRIKNHFRAHQLSIWLRL 684
                       .|..||   ||  ||:||...:.....:..::|.|..|
Mouse   514 -----------HWPEYD---QKEGYLKIGASTQAAQRLKDKEVSFWAEL 548

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	190/659 (29%)
Ces1d	NP_444430.2	COesterase	24..545	CDD:278561	194/673 (29%)
		Aes	<121..>239	CDD:223730	50/123 (41%)
		Prevents secretion from ER. /evidence=ECO:0000255	562..565
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810