Protein Alignment Nlg4 and ces2.2

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_004913616.1
• Gene: ces2.2 / 100493994
• XenbaseID: XB-GENE-29081995
• Length: 568
• Species: Xenopus tropicalis
• Alignment Length: 712
• Identity: 193/712 - (27%)
• Similarity: 292/712 - (41%)
• Gaps: 182/712 - (25%)

  Fly     5 QLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEV 69
            |:..|::||||         |  .:|.:|| |......::.|:||:|.|..:......  |.|.|
 Frog    11 QMGSLIKLLLL---------C--CATLEIY-GTEDARPLLTTKYGQLLGNTVGAKETD--RLVHV 61

  Fly    70 FLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKR 134
            |:|||:|.||....||...:.|.||..:|.:....|:|.|       :...:|.:    .|:.|.
 Frog    62 FMGVPFAKPPIGPLRFEAPQPPEPWSSVREATAAPPMCLQ-------DKRGMEDL----AEFFKA 115

  Fly   135 LLPFLENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTL 199
            ...| ...||||||||||:|.:.|.| .:|||:|||||.:......:.::||.|.:|..||||::
 Frog   116 KFDF-PPVSEDCLYLNVFTPADRGEN-PELPVMVFIHGGALTMGGASMFEGSALCAYENVVVVSI 178

  Fly   200 NYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINY 264
            .|||||:||.::...   ..| .|:|.:||:|||.|::.||:.|||:|.|||:.|...|...::.
 Frog   179 QYRLGIMGFFSSGDK---EVR-GNFGFLDQVAALQWVRDNIKDFGGNPQSVTIFGESAGGVSVSA 239

  Fly   265 LMTSPTMVRGLFHRAILMSGSAYSSWALVED-----PVLFAIKLAKEVNCTIPDDINRHHEQIVD 324
            .:.|| :.:||||:||..||.|.....:...     |:|..:  |...:|::.|        :|.
 Frog   240 QVLSP-LSKGLFHKAIAESGVAILPGLMTSKTEEILPLLSVV--ANISSCSVSD--------LVG 293

  Fly   325 CLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVI-RPGHSNLDIDDLMARNSRRSSADSGFQSSAG 388
            ||:. ..||..:|...|..||. |...||||.: :|..     :.|.|:.|
 Frog   294 CLKK-KTEDEIIAITAAMRFLV-FPAVVDGVFLPKPAE-----EILAAKES-------------- 337

  Fly   389 GGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGF- 452
                                                 .....|.|:...|..|.........|:
 Frog   338 -------------------------------------NPVPFLIGINNHEFGWILPLSLNITGYR 365

  Fly   453 EGERRDKIIRTY--------VRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQ 509
            ||..:..|..|.        |.:|..:.:.|.|       .|.|    .|...|:..:..:.|..
 Frog   366 EGMEKKNIQATLGALPLLNTVSSAIPFIMEEYF-------GDTD----DPKELRNNFLDLVGDII 419

  Fly   510 FVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQ------TKD 568
            ||.|.:|.           ......:|.|                  .|||.|.::      :||
 Frog   420 FVIPALRT-----------AKYHRDSGFP------------------VYFYEFQHRPSMYADSKD 455

  Fly   569 GDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQD 633
             |:   :...||::|.::.|.|.:.....|..|.|:.|..||:.:|.:|.||||.|:||
 Frog   456 -DF---VKADHGDELYFVVGGPFLKSGILFKSNGTEEEKILSKTIMKYWANFARNGDPN------ 510

  Fly   634 SSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMED 695
             .|.:::         |..||. .:.||||.:..:.....:..:|..|...:|:..:..||:
 Frog   511 -GLGLAE---------WPKYDE-DEDYLEINLTQKSSQRLKGGRLKFWTITLPDKIKELMEE 561

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	178/658 (27%)
ces2.2	XP_004913616.1	COesterase	36..547	CDD:395084	178/659 (27%)