DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and nlgn4x

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	XP_017946613.1	Gene:	nlgn4x / 100329189	XenbaseID:	XB-GENE-6036018	Length:	833	Species:	Xenopus tropicalis

Alignment Length:	1012	Identity:	304/1012 - (30%)
Similarity:	448/1012 - (44%)	Gaps:	266/1012 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LLLLRLLLLPTV------LISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLR 65
            ||.|.|:..|..      |:.|:  |..:........:..|.||.|.||::.|...|| ....|.
Frog     7 LLWLPLIFTPVCVLVNSNLLLWI--AALAVRFTIVDCQAQHPIVPTNYGKIRGTRTPL-PIEILG 68

  Fly    66 SVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKM-PKGRL 129
            .||.:||||||:|||.:.||.|...|:.|.||:.:.:::|||||.|    :|.:.|..| |....
Frog    69 PVEQYLGVPYASPPTGERRFQPPEPPSSWTGIKNATQFAPVCPQFL----DERSLLNDMLPIWFT 129

  Fly   130 EYLKRLLPFLENQSEDCLYLNVFSPVNAGANEK----------------------KLPVIVFIHG 172
            ..|..::.::::|:|||||||::.|...||..|                      |.||:|:|||
Frog   130 ANLDTVVSYVQDQNEDCLYLNIYVPTEDGATTKKQADDIANNDRGEDEDIHDPNNKKPVMVYIHG 194

  Fly   173 ESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQ 237
            .|:...:||..|||:|||:|.|:|:|:|||||:||||:...    .|...||||:||:.||.||:
Frog   195 GSYMEGTGNMIDGSILASHGNVIVITVNYRLGVLGFLSTGD----QAAKGNYGLLDQIQALRWIE 255

  Fly   238 QNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIK 302
            :||..|||||..||:.|.|.||:|:: |:|......|||.:||:.||:|.||||:...|..:...
Frog   256 ENIGAFGGDPKRVTIFGSGAGASCVS-LLTLSHYSEGLFQKAIIQSGTALSSWAVNYQPAKYTRI 319

  Fly   303 LAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDID 367
            ||.:|.|.:.|.|:     :|:||||...::|....|....:..:|||.:||.||.        |
Frog   320 LADKVGCDMLDTID-----LVECLRDKNYKELIQQSITPATYHIAFGPVIDGDVIP--------D 371

  Fly   368 D---LMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYD 429
            |   ||.:                                       |.|       :|    ||
Frog   372 DPQILMEQ---------------------------------------GEF-------LN----YD 386

  Fly   430 VLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNY-----HLNEIFYTIVNEYTDW 487
            ::.||..||.: :|  ...|.::|......|..:..:|.|.|.|     .|.|   ||...||||
Frog   387 IMLGVNQGEGL-KFVDGMVDNEDGVSLSDFDFSVSNFVDNLYGYPEGKDTLRE---TIKFMYTDW 447

  Fly   488 DRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQ 552
             ...::|...|.|.||..:|.|:|||.|...|:.|           ..|||
Frog   448 -ADKENPETRRKTLVALFTDHQWVAPAVATADLHA-----------RYGSP-------------- 486

  Fly   553 PSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFW 617
                .|||.|.:..:....|....:.||:::||:||.|::.....|..|::|::..||..||.:|
Frog   487 ----TYFYAFYHHCQSEMKPTWADSAHGDEVPYVFGIPMIGPTELFNCNFSKNDVMLSAVVMTYW 547

  Fly   618 TNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWL 682
            ||||:||:||:...||:.. :..:.|||..:.|..|||..|.||.||:|||:::|:||.:::.||
Frog   548 TNFAKTGDPNKPVPQDTKF-IHTKPNRFEEVAWSKYDPKDQLYLHIGLKPRVRDHYRATKVAFWL 611

  Fly   683 RLIPELHRAGMEDVIARHNLFR--------NHDDMDLY-----EGPVKPDPFGISTAAGASGSSS 734
            .|:|.||..        :.:|:        ...||..|     ..|:||   .|:|...|...::
Frog   612 ELVPHLHNL--------NEIFQYVSTTTKVPPPDMTSYPHVTRRPPLKP---RITTKRPAMTPAN 665

  Fly   735 SSSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTT 799
            ::..:.:                       .:||..|:
Frog   666 NAKETQK-----------------------NVLGENTI--------------------------- 680

  Fly   800 LANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQ 864
            :.....|             |||.||||||:|.|||.||:|.||.:||::||.|.|.
Frog   681 ITEDKRD-------------YSTELSVTIAVGASLLFLNILAFAALYYKKDKRRHET-------- 724

  Fly   865 QRSLHQQVPYPPEPIKHAHYHMGHSQSSANVIVDVE----SHQDQAGQAAMLLQAA-----AAAA 920
                |::    |.|.::....:.|.|:...:.:.::    .|:.:|.||...|:..     ....
Frog   725 ----HRR----PSPQRNTTNDIAHIQNEEIMSLQMKQLEHDHECEALQAHDTLRLTCPPDYTLTL 781

  Fly   921 AAAANDVKPPPPHICSN-----TGMQQQQQVGGGSGG 952
            ..:.:|:....|:..:.     ||||........|||
Frog   782 RRSPDDIPLMTPNTITMIPNTLTGMQPLHTFNTFSGG 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	232/670 (35%)
nlgn4x	XP_017946613.1	COesterase	46..610	CDD:365897	232/671 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	433	1.000	Inparanoid score	I1667
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.070