Protein Alignment Nlg4 and nlgn3

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: XP_012823589.1
• Gene: nlgn3 / 100329188
• XenbaseID: XB-GENE-977261
• Length: 843
• Species: Xenopus tropicalis
• Alignment Length: 1026
• Identity: 322/1026 - (31%)
• Similarity: 452/1026 - (44%)
• Gaps: 260/1026 - (25%)

  Fly     5 QLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEV 69
            :|.|:|.:|.:.:.::|       |.|.:|.      :.|.|.||:|.|..:||.| ..|..|:.
 Frog    12 KLSLVLWVLSVTSRVLS-------SHAQVYS------QTVNTHYGKLRGTRVPLPS-EILGPVDQ 62

  Fly    70 FLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKR 134
            :||||||.||..:.||.|...|..|.|||.:..:||||||   ||||....: .||......|..
 Frog    63 YLGVPYAAPPVGEKRFLPPEPPPSWSGIRNATHFSPVCPQ---NIQNAVPDI-MMPVWFTSNLDT 123

  Fly   135 LLPFLENQSEDCLYLNVFSPV--------------------NAGANEKK---------------- 163
            :..:|:.|||||||||::.|.                    ..|.:.||
 Frog   124 VTGYLQEQSEDCLYLNIYVPTEDVKRISKECVRKPNKKICRKGGPSAKKQGEELSDNDEDEEGDI 188

  Fly   164 -----LPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVAN 223
                 .||:|:|||.|:...|||..|||||||||.|||:|||||:|:||||:...    .|...|
 Frog   189 RDTGAKPVMVYIHGGSYMEGSGNMIDGSVLASYGNVVVITLNYRVGVLGFLSTGD----QAAKGN 249

  Fly   224 YGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYS 288
            |||:||:.||.|:.:|:..|||||:.:|:.|.|.||:|:: |:|......|||.|||:.||||.|
 Frog   250 YGLLDQIQALRWVSENVAFFGGDPHRITVFGSGIGASCVS-LLTLSHHSEGLFQRAIIQSGSALS 313

  Fly   289 SWALVEDPVLFAIKLAKEVNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVD 353
            |||:...||.:...||::|.|.:.|.::     :|||||....::|...|||...:..:|||.:|
 Frog   314 SWAVNYQPVKYTRLLAEKVGCNVLDTVD-----MVDCLRQKSAKELVEQDIQPARYHVAFGPVID 373

  Fly   354 GVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSG 418
            |.||..     |.:.||.:                                       |.|
 Frog   374 GDVIPD-----DPEILMEQ---------------------------------------GEF---- 390

  Fly   419 AGTMNMGGHYDVLFGVVTGESIWRF--SAHDIQNGFEGERRDKIIRTYVRNAYNY-----HLNEI 476
               :|    ||::.||..||.: :|  :..|.::|..|...|..:..:|.|.|.|     .|.|
 Frog   391 ---LN----YDIMLGVNQGEGL-KFVENVVDAEDGVSGSDFDYSVSNFVDNLYGYPEGKDTLRE- 446

  Fly   477 FYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGA 540
              ||...|||| ||  .:|...|.|.||..:|.|:|.|.|...|:.|           ..|||
 Frog   447 --TIKFMYTDWADR--DNPETRRKTLVALFTDHQWVEPSVVTADLHA-----------RYGSP-- 494

  Fly   541 NAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKS 605
                            .|||.|.:..:....|......||:::||:||.|:|.....||.|::|:
 Frog   495 ----------------TYFYAFYHHCQSLMKPAWADAAHGDEVPYVFGVPMVGPTDLFPCNFSKN 543

  Fly   606 ETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIK 670
            :..||..||.:|||||:||:||:...||:.. :..:.|||..:.|..|:|..|.||.||:|||::
 Frog   544 DVMLSAVVMTYWTNFAKTGDPNKPVPQDTKF-IHTKANRFEEVAWSKYNPRDQLYLHIGLKPRVR 607

  Fly   671 NHFRAHQLSIWLRLIPELHRAGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSS 735
            :|:||.:::.|..|:|.|:               |..||..|.        ..:|....|.::.:
 Frog   608 DHYRATKVAFWKHLVPHLY---------------NLHDMFHYT--------STTTKVPPSDTTQN 649

  Fly   736 SSSSSRLLLVDEQLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTL 800
            |..:.|..:.|     .|..|:  |...||.:.....|.:       |:.           |..:
 Frog   650 SHITRRPKVWD-----TKRPGV--SPTFNGPVAKWDPELD-------PVD-----------PVVI 689

  Fly   801 ANASSDTLASGFEAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQ 865
            .:...              |||.||||||:|.|||.||||.||.:||:.||.|.:  |.::...|
 Frog   690 QDPRD--------------YSTELSVTIAVGASLLFLNVLAFAALYYRNDKRRQD--TQRQPSPQ 738

  Fly   866 R------SLHQQVPYPPEPIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAAAAAAA 924
            |      ..|.  |.|||.:.....:.||.:....   .|..|.:   .....|.........:.
 Frog   739 RPAVTRDPAHS--PVPPEELNSLQINAGHPECEGG---GVSGHDN---LRLPTLPDYTLTLRRSP 795

  Fly   925 NDVKPPPPHICSNT---------GMQQQQQVGGGSGGALNNGGIEGSKVTT 966
            :|:    |.:..||         |:|........|.| .||.|:..|..||
 Frog   796 DDI----PLMTPNTITMIPNSLVGLQSLHPYNTFSAG-FNNTGLPHSHSTT 841

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	242/686 (35%)
nlgn3	XP_012823589.1	COesterase	35..618	CDD:395084	242/694 (35%)