Protein Alignment Nlg4 and ces2

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001120019.1
• Gene: ces2 / 100144981
• XenbaseID: XB-GENE-6467140
• Length: 557
• Species: Xenopus tropicalis
• Alignment Length: 712
• Identity: 188/712 - (26%)
• Similarity: 289/712 - (40%)
• Gaps: 190/712 - (26%)

  Fly     9 LLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGV 73
            |:::|||         |  .:|.:|| |......::.|:||:|.|..:......  |.|.||:||
 Frog     4 LIKVLLL---------C--CATLEIY-GTEDARPLLMTKYGQLLGKTVGAKETD--RLVHVFMGV 54

  Fly    74 PYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLEYLKRLLPF 138
            |:|.||....||...:.|.||..:|.:...||:|.|       :...:|.:    .::.|....|
 Frog    55 PFAKPPIGPLRFEAPQPPEPWSSVREATAPSPMCLQ-------DKEVMELL----ADFFKAKFDF 108

  Fly   139 LENQSEDCLYLNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRL 203
             ...||||||||||:|.:.|.| ..|||:|||||........:.::||.|::|..||||::.|||
 Frog   109 -SRVSEDCLYLNVFTPADKGEN-PGLPVMVFIHGGGLAIGGASMFEGSALSAYENVVVVSIQYRL 171

  Fly   204 GILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTS 268
            ||:|||:....   ..| .|:|.:||:|||.|::.||:.|||||.|||:.|...|...::.|:.|
 Frog   172 GIMGFLSTGDK---EVR-GNFGFLDQVAALQWVRDNIKDFGGDPQSVTIFGESAGGLSVSALVLS 232

  Fly   269 PTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEV-----------NCTIPDDINRHHEQI 322
            | :..|||||||..||.|..       |.|.|.| .:|:           :|::.|        :
 Frog   233 P-LSEGLFHRAIAESGVAIL-------PGLTASK-TEEILPLLDMVINVSSCSVSD--------L 280

  Fly   323 VDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVI-RPGHSNLDIDDLMARNSRRSSADSGFQSS 386
            |.||::...::  :.:|.|......|...||||.: :|..     :.|.|:.|.......|..:.
 Frog   281 VGCLKNKTEDE--IIEITAAMRYVIFPAVVDGVFLPKPAE-----EILAAKESHPVPFLIGINNH 338

  Fly   387 AGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNG 451
            .                          ||.....|:|:.|:.:.:
 Frog   339 E--------------------------FGSMLPVTLNITGYREGM-------------------- 357

  Fly   452 FEGERRD--------KIIRTYVRNAYNYHLNEIFYTIVNEYTDWDRTSQHPINTRDTAVAALSDA 508
               |::|        .::.|         ::.:...|:.||..   .:..|...|:..:....|.
 Frog   358 ---EKKDIQAILGALPLLNT---------VSSVIPFIMEEYFG---DTNDPKELRNNFLDLAGDI 407

  Fly   509 QFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFD-----YQTKD 568
            .||.|.:|.           ......:|.|                  .|||.|.     |....
 Frog   408 IFVIPALRT-----------AKYHRDSGFP------------------VYFYEFQHRPSLYADSK 443

  Fly   569 GDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQD 633
            .|:   :...||::|.::.|.|.:.....|..|.|:.|..||:.:|.:|.||||.|:||.|...:
 Frog   444 EDF---VKADHGDELYFVGGGPFLKNGILFKSNGTEEEKILSKTIMKYWANFARNGDPNGHGLAE 505

  Fly   634 SSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAGMED 695
                            |..||. .:.||||.:..:.....:..:...|...:|:..:..||:
 Frog   506 ----------------WPKYDE-DEDYLEINLTQKSSQRLKGERFEFWTITLPDKIQKLMEE 550

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	175/662 (26%)
ces2	NP_001120019.1	COesterase	25..536	CDD:395084	175/663 (26%)