Protein Alignment Nlg4 and Ces1f

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001096829.2
• Gene: Ces1f / 100125372
• RGDID: 1642419
• Length: 561
• Species: Rattus norvegicus
• Alignment Length: 699
• Identity: 197/699 - (28%)
• Similarity: 287/699 - (41%)
• Gaps: 173/699 - (24%)

  Fly    20 ISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLRSVEVFLGVPYATPPTKQNR 84
            :|::.....:|..:| |......:|.|..|::.|..:.|:.  ..:||.||||||:|.||....|
  Rat     3 LSFLFLVSLATCVVY-GNPSSPPVVDTTKGKVLGKYVSLEG--VTQSVAVFLGVPFAKPPLGSLR 64

  Fly    85 FSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAAL-EKMPKGRLEYLKRLLPFLENQSEDCLY 148
            |:|.:...||..::.:..|.|:|.|.....|.....| .:..|..||:           ||||||
  Rat    65 FAPPQPAEPWSFVKNTTTYPPMCSQDAAKGQRMNDLLTNRKEKIHLEF-----------SEDCLY 118

  Fly   149 LNVFSPVNAGANEKKLPVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANP 213
            ||:::|.:...| .:|||:|:|||........:.|||.||::|..||||.:.|||||.||.:...
  Rat   119 LNIYTPADFTKN-SRLPVMVWIHGGGMTLGGASTYDGRVLSAYENVVVVAIQYRLGIWGFFSTGD 182

  Fly   214 NPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHR 278
            .   |:| .|:|.:||:|||||:|.||..|||||.|||:.|...|...::.|:.|| :.:.||||
  Rat   183 E---HSR-GNWGHLDQVAALHWVQDNIANFGGDPGSVTIFGESAGGFSVSVLVLSP-LTKNLFHR 242

  Fly   279 AILMSGSAYSSWALVEDPVLFAIKLAKEVNC-TIPDDINRHHEQIVDCLRDVPLEDLY------- 335
            ||..||..:....|.:|....|.::|....| |....|      ||.|||....|:|.
  Rat   243 AISESGVVFLPGLLTKDVRPAAKQIADMAGCETTTSAI------IVHCLRQKTEEELLEIMKKMN 301

  Fly   336 LADI-------QAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGGQ 393
            |..:       ::.:||::.   ||.||             :.::.:...|:..|.:
  Rat   302 LIKLSSQRDNKESYHFLSTV---VDNVV-------------LPKDPKEILAEKNFNT-------- 342

  Fly   394 GGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSAHDIQNGF---EGE 455
                                              ...:.|:...|..|....   ..||   :.|
  Rat   343 ----------------------------------VPYIVGINKQECGWLLPT---MMGFVPADVE 370

  Fly   456 RRDKIIRTYVRN-AYNYHLNE-IFYTIVNEYTDWDRTSQHPINTRDTAVAALSDAQFVAPIVRAG 518
            ...|:..|.:.. |..|.:.| |....:.:|.   :.|...|..||..:|.:.|..|..|.|...
  Rat   371 LDKKMAITLLEKFASLYGIPEDIIPVAIEKYR---KGSDDSIKIRDGILAFIGDVSFSIPSVMVS 432

  Fly   519 DILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGDYPQRMGTV---HG 580
                       .....||:|                  .|.|.:.|...... |||...|   |.
  Rat   433 -----------RDHRDAGAP------------------TYMYEYQYYPSFSS-PQRPKHVVGDHA 467

  Fly   581 EDLPYIFGAPLV-DGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPNEHHRQDSSLPVSKERNR 644
            :||..:||||:: ||.|       :.|..||:.||.||.||||.||||     ...||
  Rat   468 DDLYSVFGAPILRDGAS-------EEEIKLSKMVMKFWANFARNGNPN-----GRGLP------- 513

  Fly   645 FRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLI----PELH 689
                .|..||. .::||:||...:.....:|.:::.|.:|:    |:.|
  Rat   514 ----HWPQYDQ-KEEYLQIGATTQQSQRLKAEEVAFWTQLLAKRQPQPH 557

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	189/662 (29%)
Ces1f	NP_001096829.2	COesterase	22..545	CDD:395084	189/665 (28%)
		Prevents secretion from ER. /evidence=ECO:0000255|PROSITE-ProRule:PRU10138	558..561		197/699 (28%)