Protein Alignment Nlg4 and Nlgn4l

DIOPT Version :10

• Sequence 1: NP_001369025.1
• Gene: Nlg4 / 42402
• FlyBaseID: FBgn0083975
• Length: 1437
• Species: Drosophila melanogaster
• Sequence 2: NP_001423254.1
• Gene: Nlgn4l / 100113365
• MGIID: 3775191
• Length: 945
• Species: Mus musculus
• Alignment Length: 1110
• Identity: 339/1110 - (30%)
• Similarity: 461/1110 - (41%)
• Gaps: 298/1110 - (26%)

  Fly    43 IVQTRYGRLHGL--ILPLDSFRFLRSVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSP 105
            :|.|.||:|.|:  .||.|   .|..|..|||||||.|||.:.||.|...|:.|.|:|.:.:::|
Mouse    30 VVATNYGKLRGVRAALPGD---VLGPVTQFLGVPYAAPPTGERRFQPPEPPSSWAGVRDATRFAP 91

  Fly   106 VCPQRLPNIQNETAAL-EKMPKGRLEYLKRLLPFLENQSEDCLYLNVFSPVNAGANEKKL----- 164
            ||||.|    :|.|.| :::|......|..:..::::|||||||||::.|  .|||.||:
Mouse    92 VCPQHL----DERALLRDRLPAWFAANLDAIAAYVQDQSEDCLYLNLYVP--GGANGKKMADDVT 150

  Fly   165 -------------------------PVIVFIHGESFEWSSGNPYDGSVLASYGEVVVVTLNYRLG 204
                                     ||:|:|||.|:...:.|..|||||||||:|:|||:|||||
Mouse   151 GNDHGDDQDSRDPGVGGAAAAAARKPVMVYIHGGSYMEGTANIVDGSVLASYGDVIVVTVNYRLG 215

  Fly   205 ILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQKFGGDPNSVTLAGHGTGAACINYLMTSP 269
            :||||:...    .|...||||:||:.||.|:::|...|||||:.||:.|.|.||:|:: |:|..
Mouse   216 VLGFLSTGD----QAAKGNYGLLDQIQALRWVEENAGAFGGDPDRVTVFGSGAGASCVS-LLTLS 275

  Fly   270 TMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKEVNCTIPDDINR-------HHEQIVDCLR 327
            ....|||.:||:.||:|.||||:...|..:|..|.:.|.|..||..:.       ....:|.|||
Mouse   276 HYSEGLFQKAIIQSGTALSSWAVNYQPARYARALGERVGCATPDPGSPPGSPPGWDSASLVSCLR 340

  Fly   328 DVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMARNSRRSSADSGFQSSAGGGGG 392
            .....:|..|.:....:..:|||:|||.||.      |...::.......:.|.....:.|.|..
Mouse   341 GKAAGELARARVTPATYHVAFGPTVDGDVIP------DDPQILMEQGEFLNYDIMLGVNQGEGAR 399

  Fly   393 QGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVTGESIWRFSA--HDIQNGFEGE 455
            ...|.|||..||.| .:||||.||.....:..||......||..||.....|.  :|:....||
Mouse   400 FVDGLGGGHDGGYG-GYGGGYGGGVEDDEVQDGGPDGAAGGVSAGEFDLAVSGFINDLYGRPEG- 462

  Fly   456 RRDKIIRTYVRNAYNYHLNEIFYTIVNEYTDW-DRTSQHPINTRDTAVAALSDAQFVAPIVRAGD 519
             |...:|.               |:...|||| ||.|  |...|.|.||..:|.|:|||.|...|
Mouse   463 -RGDALRE---------------TVKFMYTDWADRDS--PEARRKTLVALFTDHQWVAPAVATAD 509

  Fly   520 ILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFYVFDYQTKDGD-------------- 570
            :.|           ..|||                  .|||.|.::...|.
Mouse   510 LHA-----------RYGSP------------------TYFYAFYHRCHGGGGGGGGVDGVAGGVA 545

  Fly   571 --------YPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGNPN 627
                    .|......||:::||:||.|:......|..|:::::..||..||.:|||||:||:||
Mouse   546 GGVGGEEARPAWADAAHGDEVPYVFGVPMAGPGDVFGCNFSRNDVMLSAVVMTYWTNFAKTGDPN 610

  Fly   628 EHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHRAG 692
            :...||:.. |....|||..:.|..|||..|.||.||::||:::|:||.:::.||.|:|.||...
Mouse   611 QPVAQDTRF-VHTRPNRFEEVAWAKYDPRGQLYLHIGLRPRVRDHYRAAKVAFWLELVPHLHGLA 674

  Fly   693 MEDVIARHNLFRNHDDMDLY----------EGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDE 747
            .              |...|          .|....||      .|..|.......::|...|..
Mouse   675 A--------------DPGAYLSAAATRAAPSGDPDRDP------GGGGGGRRRPRPATRRPAVMT 719

  Fly   748 QLMMKKGRGLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGF 812
            ...|..|.|:..|:                       |...:||.|..|...|.....|
Mouse   720 SSSMASGSGMTSSS-----------------------GSGMTSSSGSSASAVLIETRRD------ 755

  Fly   813 EAAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPE 877
                   |||.||||||:|.|||.||||.||.:||::||.|.|.            |::.| ||.
Mouse   756 -------YSTELSVTIAVGASLLFLNVLAFAALYYKKDKRRHET------------HRRPP-PPR 800

  Fly   878 PIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAAAAAAANDVKPPPP-----HICSN 937
            |                                  .||..:||||..|....|.|     ..|..
Mouse   801 P----------------------------------PQAPPSAAAADRNPRPDPGPAGRRGGECGA 831

  Fly   938 --TGMQQQQQVGG---------GSGGALNNGGIEGSKVTTDNLGNVTYSTSSKQQQQHQQQQQQQ 991
              |.|..:...||         |.||.:  ||:.|.::...    ..|:.:.::
Mouse   832 VVTAMAAEASAGGLGHDGVGGVGVGGVI--GGVAGLRLACP----PDYALTLRR----------- 879

  Fly   992 QREHMQIKGMTGTQTFGRSGSGSG------GGAGGGAGSASGGASVVVSGSSVSYNPGMMTLPKS 1050
                       ......|:|:|.|      |..|||.|.|..|.:...||..|:...|:.|....
Mouse   880 -----------SPDDVPRAGAGPGAMTLIPGALGGGGGGAVHGFNTFGSGVGVAGVAGVATSQAG 933

  Fly  1051 GGLHH 1055
            .||.|
Mouse   934 PGLPH 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	243/702 (35%)
Nlgn4l	NP_001423254.1	COesterase	30..663	CDD:395084	243/702 (35%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..167		0/21 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	685..742		14/85 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	787..828		17/87 (20%)