DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Nlg4 and nlgn2b

DIOPT Version :9

Sequence 1:	NP_001369025.1	Gene:	Nlg4 / 42402	FlyBaseID:	FBgn0083975	Length:	1437	Species:	Drosophila melanogaster
Sequence 2:	NP_001159808.1	Gene:	nlgn2b / 100002407	ZFINID:	ZDB-GENE-090918-3	Length:	860	Species:	Danio rerio

Alignment Length:	968	Identity:	295/968 - (30%)
Similarity:	431/968 - (44%)	Gaps:	227/968 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MGESQLLLLLRLLLLPTVLISWMHCAGASTADIYKGARLGHRIVQTRYGRLHGLILPLDSFRFLR 65
            :.::.|:.||.|.|  .:.:|....|..:||.        |.:|.|.||:|.|:...|:: ..|.
Zfish    21 ISDTCLVWLLGLAL--RLALSSCQRADLTTAK--------HPMVTTGYGKLRGVRKELNN-EILG 74

  Fly    66 SVEVFLGVPYATPPTKQNRFSPTRAPAPWDGIRISDKYSPVCPQRLPNIQNETAALEKMPKGRLE 130
            .||.:|||||||||..:.||.|..||..|..||.:.:::|||||.:..:..|.    .:|....:
Zfish    75 PVEQYLGVPYATPPVGERRFQPPEAPGSWQEIRNATQFAPVCPQNIHGVLPEI----MLPVWFTD 135

  Fly   131 YLKRLLPFLENQSEDCLYLNVFSPVNAG-------------------ANEKKLPVIVFIHGESFE 176
            .|.....:::|||||||||||:.|...|                   .:.:|.||::||||.||.
Zfish   136 NLDAAAAYVQNQSEDCLYLNVYVPTEDGPLTKKHDESSMNRPRDEDIRDRRKKPVMLFIHGGSFM 200

  Fly   177 WSSGNPYDGSVLASYGEVVVVTLNYRLGILGFLNANPNPHAHARVANYGLMDQMAALHWIQQNIQ 241
            ..:||.:|.||||:||.|:|||:|||||:||||::..    .:...||||:||:.||.|:.:||.
Zfish   201 EGTGNMFDASVLAAYGNVIVVTMNYRLGVLGFLSSGD----QSAKGNYGLLDQIQALRWLNENIG 261

  Fly   242 KFGGDPNSVTLAGHGTGAACINYLMTSPTMVRGLFHRAILMSGSAYSSWALVEDPVLFAIKLAKE 306
            .|||||..:|:.|.|.||:|:|.|:.|... .|||.|||..||||.|||::...|:::...|||:
Zfish   262 HFGGDPERITIFGSGAGASCVNLLILSHHS-EGLFQRAIAQSGSAISSWSVNYRPLMYTKILAKK 325

  Fly   307 VNCTIPDDINRHHEQIVDCLRDVPLEDLYLADIQAPNFLTSFGPSVDGVVIRPGHSNLDIDDLMA 371
            |.|:..|..:     :|||||.....:|...|:|...:..:|||.|||.|:..     |.:.||.
Zfish   326 VGCSYSDTAD-----LVDCLRRKSYRELVDQDVQPARYHIAFGPVVDGDVVPD-----DPEILMQ 380

  Fly   372 RNSRRSSADSGFQSSAGGGGGQGGGAGGGGGGGSGSSFGGGYFGGSGAGTMNMGGHYDVLFGVVT 436
            :                                       |.|       :|    ||:|.||..
Zfish   381 Q---------------------------------------GEF-------LN----YDILLGVNQ 395

  Fly   437 GESIWRFSAHDIQNGFEGERRDKIIRTYVRNAYNYH-----LNEIFYTIVNEYTDW-DRTSQHPI 495
            ||.:.....::.:.|......|..|..:|.|.|.|.     |.|   ||...|||| ||.:..
Zfish   396 GEGLKFVDDNEGEEGISAASFDYTISNFVDNLYGYPEGKDILRE---TIKFMYTDWADRDNGD-- 455

  Fly   496 NTRDTAVAALSDAQFVAPIVRAGDILAANSPPPVSSSSTAGSPGANAAASTSAGSTQPSGRCYFY 560
            ..|.|.:|..:|.|:|||.|....:.|....|                             .|||
Zfish   456 MRRKTLLALFTDHQWVAPAVATAKLHAEFQSP-----------------------------VYFY 491

  Fly   561 VFDYQTKDGDYPQRMGTVHGEDLPYIFGAPLVDGFSHFPQNYTKSETALSEAVMIFWTNFARTGN 625
            .|.:..:....|:.....||:::||:||.|:|.....||.|::|::..||..||.:|||||:||:
Zfish   492 TFHHHCQTEARPEWADAAHGDEIPYVFGVPMVGATELFPCNFSKNDIMLSAVVMTYWTNFAKTGD 556

  Fly   626 PNEHHRQDSSLPVSKERNRFRSITWENYDPLHQKYLEIGMKPRIKNHFRAHQLSIWLRLIPELHR 690
            ||....||:.. :..:.|||..:.|..:....::||.||:||||::::||::::.||.|:|.||.
Zfish   557 PNIPVPQDTKF-IHTKPNRFEEVIWTKFSSKDKQYLHIGLKPRIRDNYRANKVAFWLELVPHLHT 620

  Fly   691 AGMEDVIARHNLFRNHDDMDLYEGPVKPDPFGISTAAGASGSSSSSSSSSRLLLVDEQLMMKKGR 755
            .              ||::..|...:.|   |.....|..|::.|..:.|
Zfish   621 I--------------HDEIPTYTTQLPP---GAPHRPGWKGTAQSPGTRS--------------- 653

  Fly   756 GLNGSAYLNGILGVTTVEPNNMYTTCIPIGGNYSSSGGVFAPTTLANASSDTLASGFE------- 813
                           |..|                        |::....|....|.|
Zfish   654 ---------------TRHP------------------------TVSTYPPDPDLEGSEHPPERFP 679

  Fly   814 -AAGYAAYSTALSVTIAIGCSLLILNVLIFAGVYYQRDKTRLEVKTLQKQYQQRSLHQQVPYPPE 877
             .:....|||.||||:|:|.|||.||||.||.:||:|||..   :.||:::::.| .|:...|..
Zfish   680 FPSNTRDYSTELSVTVAVGASLLFLNVLAFAALYYKRDKRH---ELLQRRHRRLS-PQRGAVPGV 740

  Fly   878 PIKHAHYHMGHSQSSANVIVDVESHQDQAGQAAMLLQAAAAAAAAAANDVKPPPPHIC 935
            .|.....|...:.|....::.::..|    |...|.............|::|..|.:|
Zfish   741 GIVGGPPHNDLALSQEEELMSLQMKQ----QRVELDHGTPLPTRGLHGDLEPLRPPVC 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Nlg4	NP_001369025.1	COesterase	43..681	CDD:395084	226/662 (34%)
nlgn2b	NP_001159808.1	COesterase	47..611	CDD:278561	229/676 (34%)
nlgn2b	NP_001159808.1	Aes	<181..>279	CDD:223730	50/101 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	439	1.000	Inparanoid score	I1641
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	1	1.000	-	-		FOG0000662
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_101617
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X375
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	10	9.830