DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10887 and Leo1

DIOPT Version :9

Sequence 1:	NP_650866.1	Gene:	CG10887 / 42399	FlyBaseID:	FBgn0038773	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001034611.1	Gene:	Leo1 / 235497	MGIID:	2685031	Length:	667	Species:	Mus musculus

Alignment Length:	729	Identity:	173/729 - (23%)
Similarity:	287/729 - (39%)	Gaps:	148/729 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KDGES---SESWPAFNRRSPNPSFSSVDQQ--------GNKTKARRQHQSRSHSFHSTANSVPES 66
            ||.||   |:|.........|.|.|..||.        .||.......:....|.||.:::..|.
Mouse    19 KDSESESDSDSDQDNGASGSNASGSESDQDDRGDSGQPSNKELFGDDSEEEGASHHSGSDNHSER 83

  Fly    67 QGPLESRSDLNAKTSSKSERPYISTSNS---SWTSESSSGSPPDSGESSSFSTSSSLSSSLLCAP 128
            .   ::||:.:.::..:...|.....:|   :...:...|...|.|...|.:..|..:.|
Mouse    84 S---DNRSEASERSDHEDNEPSDEDQHSGSEAHNDDDDEGHRSDEGSRHSEAEGSEKAQS----- 140

  Fly   129 EPKSINWSNPKSSSNISNETTTSAGQVGGIPSFSESDDQGSVDSETVSNIRKSTSLIELKDNFNT 193
              ....|.....|....:|...:        |..|..:|||.:.:..::......:....|....
Mouse   141 --DDEKWDGEDKSDQSDDEKLQN--------SDDEDREQGSDEDKLQNSDDDEEKMQNTDDEDRA 195

  Fly   194 IIDEDNNQQLSNE--GNILSPGTVSISNFPSSNEVANGLIDEMEQDLLSKQHSTSTPINKSNTME 256
            .|.:|:.||||.|  ||......|:..|            ||.:|:        |...::....:
Mouse   196 QISDDDRQQLSEEEKGNSDDEHPVASDN------------DEEKQN--------SDDEDQPQVSD 240

  Fly   257 KELLPLQCSSFPPTSSEGNILKPRVNPVPLGPSSNTEYESNGKNYNIEKRLSQLRYSSDEKESDV 321
            :|.:.......|..|.|.            |..|:.|.|.:.|        |:....|| .|.:|
Mouse   241 EEKMQNSDDERPQVSDED------------GRRSDGEEEQDQK--------SESARGSD-SEDEV 284

  Fly   322 L-----------SYASSDSLDLNFDYGDNAKNQNG------------NGMNGEVNGDKESQVLD- 362
            |           |.|.||:        :..|:.||            :|.:||.......|.:|
Mouse   285 LRLKRKNAIPSDSEADSDT--------EVPKDNNGTMDLFGGADDISSGSDGEDKPPTPGQPVDE 341

  Fly   363 --IEEQRKPFEKDVAVKFQTTITTQNCGLLKGPSQFLKMPYFIPVESKAYVPETFQDRMTKNDLK 425
              :.:.::..|.....:.:..|...|.. |.....|:|:|.|:.||.:.:.|:.::|.....::.
Mouse   342 NGLPQDQQEEEPIPETRIEVEIPKVNTD-LGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEML 405

  Fly   426 DEQSREDFINRLKATVRWR----ENENKTKESNAKIVRWSDGSETFHVGNEVFDMMHHPVTVNQN 486
            ||:.|.....:::.|:|||    |..|:.|||||:||:|||||.:.|:||||||:...|:..:.|
Mouse   406 DEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNEVFDVYKAPLQGDHN 470

  Fly   487 HLYVRLGSFYQPQGLIQNKLTVRP-MLDSNFGQSHVQALRNRATNKPQSGCVKVITNMGSNPEHD 550
            ||::|.|:..|.|.:.:.|||.|| ..||...:....:|.:|. :|.|.  ::::...|.:||..
Mouse   471 HLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRC-SKTQK--IRILPMAGRDPECQ 532

  Fly   551 HDRRMKEELSKLRQE-GREKNRALMKNHPPKRDRHYQGSDHNVAKNAGAFEEDDGEGADCETSSA 614
            ....:|:|..:||.. .||..:..|     :..:|.:|...:..:.....||::||    |:.|.
Mouse   533 RTEMIKKEEERLRASIRRESQQRRM-----REKQHQRGLSASYLEPDRYDEEEEGE----ESVSL 588

  Fly   615 LEVTNE---PMRSE------EDTEDHMDDDASW-----SSPNSQEEGKQS---SSEDDLPIGGAI 662
            ..:.|.   .:|.|      .|:::..::|.:.     ...||.|||:.|   .:|||   ..|.
Mouse   589 AAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRLLKAKKLNSDEEGESSGKRKAEDD---DKAN 650

  Fly   663 RKPTRLVYSGSDSD 676
            :|..:.|.|..:.:
Mouse   651 KKHKKYVISDEEEE 664

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10887	NP_650866.1	Leo1	396..548	CDD:281933	56/156 (36%)
Leo1	NP_001034611.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..362		79/409 (19%)
		PHA02664	<61..209	CDD:177447	29/165 (18%)
		Leo1	375..533	CDD:281933	58/160 (36%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	548..585		9/45 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	602..667		16/66 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004097
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23146
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.910