DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10887 and LEO1

DIOPT Version :9

Sequence 1:	NP_650866.1	Gene:	CG10887 / 42399	FlyBaseID:	FBgn0038773	Length:	676	Species:	Drosophila melanogaster
Sequence 2:	NP_001310832.1	Gene:	LEO1 / 123169	HGNCID:	30401	Length:	688	Species:	Homo sapiens

Alignment Length:	739	Identity:	165/739 - (22%)
Similarity:	281/739 - (38%)	Gaps:	181/739 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KDGES-----SESWPAFNRRSPNPSFSSVDQQG------NKTKARRQHQSRSHSFHSTANSVPES 66
            ||.:|     |:...|.:..:.:.|.|..|::|      ||.......:....|.||.:::..|
Human    19 KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQPSNKELFGDDSEDEGASHHSGSDNHSE- 82

  Fly    67 QGPLESRSDLNAKTSSKSERPYISTSNSSWTSESSSGSPPDSGESSSFSTSSSLSSSLLCAPEPK 131
                  |||..::.|.:|:  :.....|.....|.|.:|.|..:....|...|..|....:.:..
Human    83 ------RSDNRSEASERSD--HEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGSHHSEAEGSEKAH 139

  Fly   132 SIN--WSNPKSSSNISNETTTSAGQVGGIPSFSESDD----QGSVDSETVSNIRKSTSLIELKDN 190
            |.:  |.....|....:|            ....|||    ||| |.:.:.|......:....|.
Human   140 SDDEKWGREDKSDQSDDE------------KIQNSDDEERAQGS-DEDKLQNSDDDEKMQNTDDE 191

  Fly   191 FNTIIDEDNNQQLSNEGNILSPGTVSISNFPSSNEVANGLIDEMEQDLLSKQHSTSTPINKSNTM 255
            ....:.:|..||||.|..         :|......||:...||                 |.|:.
Human   192 ERPQLSDDERQQLSEEEK---------ANSDDERPVASDNDDE-----------------KQNSD 230

  Fly   256 EKELLPLQCSSFPPTSSEGNILKPRVNPVPLGPSSNTEYESNGKNYNIEKRLSQLRYSSDEKESD 320
            ::|                   :|::        |:.|...|..:...:....:.|:|.||:|.|
Human   231 DEE-------------------QPQL--------SDEEKMQNSDDERPQASDEEHRHSDDEEEQD 268

  Fly   321 VLSYAS--SDSLDLNFDYGDNAKNQNGNGMNGEVNGDKE-----SQVLDI--------------- 363
            ..|.::  |||.|...    ..|.:|....:.|.:.|.|     |..:|:
Human   269 HKSESARGSDSEDEVL----RMKRKNAIASDSEADSDTEVPKDNSGTMDLFGGADDISSGSDGED 329

  Fly   364 -----------------EEQRKPFEKDVAVKFQTTITTQNCGLLKGPSQFLKMPYFIPVESKAYV 411
                             :::.:|..:   .:.:..|...|.. |.....|:|:|.|:.||.:.:.
Human   330 KPPTPGQPVDENGLPQDQQEEEPIPE---TRIEVEIPKVNTD-LGNDLYFVKLPNFLSVEPRPFD 390

  Fly   412 PETFQDRMTKNDLKDEQSREDFINRLKATVRWR----ENENKTKESNAKIVRWSDGSETFHVGNE 472
            |:.::|.....::.||:.|.....:::.|:|||    |..|:.|||||:||:|||||.:.|:|||
Human   391 PQYYEDEFEDEEMLDEEGRTRLKLKVENTIRWRIRRDEEGNEIKESNARIVKWSDGSMSLHLGNE 455

  Fly   473 VFDMMHHPVTVNQNHLYVRLGSFYQPQGLIQNKLTVRP-MLDSNFGQSHVQALRNRATNKPQSGC 536
            |||:...|:..:.|||::|.|:..|.|.:.:.|||.|| ..||...:....:|.:|. :|.|.
Human   456 VFDVYKAPLQGDHNHLFIRQGTGLQGQAVFKTKLTFRPHSTDSATHRKMTLSLADRC-SKTQK-- 517

  Fly   537 VKVITNMGSNPEHDHDRRMKEELSKLRQEGR---EKNRALMKNH----------PPKRDRHYQGS 588
            ::::...|.:||......:|:|..:||...|   ::.|...|.|          |.:.|...:|.
Human   518 IRILPMAGRDPECQRTEMIKKEEERLRASIRRESQQRRMREKQHQRGLSASYLEPDRYDEEEEGE 582

  Fly   589 DH---NVAKN----------AGAFEEDDGEGADCETSSALEVTNEPMRSEEDTEDHMDDDASWSS 640
            :.   ...||          |..:..|..||::.:.:..|      :::::.|.|  ::......
Human   583 ESISLAAIKNRYKGGIREERARIYSSDSDEGSEEDKAQRL------LKAKKLTSD--EESGKRER 639

  Fly   641 PNSQEEGKQSSSEDDLPIGGAIRK 664
            |..:|..:|...|...|....:|:
Human   640 PKLKETWRQWKGEVSRPTLSFLRQ 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10887	NP_650866.1	Leo1	396..548	CDD:281933	56/156 (36%)
LEO1	NP_001310832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..357		78/419 (19%)
LEO1	NP_001310832.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	547..583		7/35 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2428
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004097
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23146
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	3.000