DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mdlc and rnf113a

DIOPT Version :9

Sequence 1:	NP_650865.1	Gene:	mdlc / 42397	FlyBaseID:	FBgn0038772	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001016034.1	Gene:	rnf113a / 548788	XenbaseID:	XB-GENE-6085683	Length:	319	Species:	Xenopus tropicalis

Alignment Length:	338	Identity:	190/338 - (56%)
Similarity:	232/338 - (68%)	Gaps:	25/338 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEEAASTSSFGFKKRNLKKGAGIRRKKETSSDESAKSSDEETKGKASALVRAENRRKRTNPNFQ 65
            |::..|...||.||| :.:|.||.:||      ||...|.||.||.....:    ::...||..|
Frog     1 MADSNAPVCSFVFKK-SARKFAGRKRK------ESDNESSEEEKGPVIRRI----KKDVVNPMIQ 54

  Fly    66 STKTMSKAKRQAGGVGDDGSSSASDDDK----LGIAYKSKREALPSGPQDQGATSINEMDTELDR 126
                  |:::|.....|..:||:.|:||    :.::|||.|.|.|.||.|.|||:..|:|||.|:
Frog    55 ------KSRQQPKDCEDYKASSSEDEDKTAKSITVSYKSTRSAKPVGPDDMGATATYELDTEKDK 113

  Fly   127 DAQAIHARALKINEELEGKADDKIYRGINNYAQYYKKQDTAAGNASSGMVRSGPIRAPAHLRATV 191
            |||||..|:.|:.|||:||.||||||||:||.::.|.:||:.|||||||||.||||||.||||||
Frog   114 DAQAIFERSQKVQEELKGKEDDKIYRGIHNYQKFVKPKDTSMGNASSGMVRKGPIRAPEHLRATV 178

  Fly   192 RWDYQPDICKDYKETGYCGFGDSCKFLHDRSDYKAGWQLEMDHENQRTGDVDSDGDDTKYEIHSD 256
            ||||||||||||||||:|||||||||||||||||.|||||.:.|..|.|    ..|:..||:.||
Frog   179 RWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQLERELEEGRYG----ANDEENYEVSSD 239

  Fly   257 EETLPFKCHICRQSFVNPVVTKCKHYFCEKCALAQYKKSQRCIICSQQTNGIFNPAKELIARLKT 321
            ||..||||.|||.||.||::|||||||||||||..|:||:||.:|:.||||:|||||||||:|:.
Frog   240 EEDFPFKCFICRDSFKNPIITKCKHYFCEKCALEHYRKSKRCYVCNTQTNGVFNPAKELIAKLEK 304

  Fly   322 NPMENSDSDEEEE 334
            :..|...||..||
Frog   305 HKAEEGGSDSSEE 317

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdlc	NP_650865.1	COG5152	<181..320	CDD:227481	101/138 (73%)
		zf-CCCH	195..221	CDD:279036	24/25 (96%)
		zf-RING_5	263..303	CDD:291308	28/39 (72%)
rnf113a	NP_001016034.1	COG5152	42..307	CDD:227481	166/278 (60%)
		zf-CCCH	182..208	CDD:279036	24/25 (96%)
		zf-C3HC4_2	247..284	CDD:290634	26/36 (72%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	163	1.000	Domainoid score	I3933
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133822
Inparanoid	1	1.050	371	1.000	Inparanoid score	I2083
OMA	1	1.010	-	-		QHG55322
OrthoDB	1	1.010	-	-		D1420266at2759
OrthoFinder	1	1.000	-	-		FOG0003160
OrthoInspector	1	1.000	-	-		oto103096
Panther	1	1.100	-	-	LDO	PTHR12930
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2079
SonicParanoid	1	1.000	-	-		X2126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110