DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mdlc and Rnf113a1

DIOPT Version :9

Sequence 1:	NP_650865.1	Gene:	mdlc / 42397	FlyBaseID:	FBgn0038772	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_001014791.1	Gene:	Rnf113a1 / 313450	RGDID:	1359693	Length:	341	Species:	Rattus norvegicus

Alignment Length:	366	Identity:	193/366 - (52%)
Similarity:	240/366 - (65%)	Gaps:	40/366 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MSEEAASTSSFG------FKKRNLKKGAGIRRKK---ETSSDESAKSSDEETKGKASALVRAENR 56
            |:|:.:..:|.|      |||.. :||...|||:   :..|.:|..||||     .||:||.|.:
  Rat     1 MAEQLSPGNSTGKVCTFLFKKPG-RKGTAGRRKRPLCDEGSGDSGSSSDE-----GSAVVRPEKK 59

  Fly    57 RKRTNPNFQSTKTMSKAKRQAGGVGDDGSSSASDDDKLGIAYKSKREALPSGPQDQGATSINEMD 121
            :...||..|.|:..:|.|...||:   .|...::.:.||:.|||.|.|.|.||:|.|||::.|:|
  Rat    60 QATHNPMIQKTRGSAKQKTNYGGL---SSEDENEPEGLGVTYKSTRSAKPVGPEDMGATAVYELD 121

  Fly   122 TELDRDAQAIHARALKINEELEGKADDKIYRGINNYAQYYKKQDTAAGNASSGMVRSGPIRAPAH 186
            ||.:||||:|..|:.||.|||.||.|||||||||||.:|.|.:||:.|||||||||.||||||.|
  Rat   122 TEKERDAQSIFERSQKIQEELRGKEDDKIYRGINNYQKYVKPKDTSMGNASSGMVRKGPIRAPEH 186

  Fly   187 LRATVRWDYQPDICKDYKETGYCGFGDSCKFLHDRSDYKAGWQLEMDHENQRTGDVDSDGDDTKY 251
            |||||||||||||||||||||:|||||||||||||||||.|||:|.:.:..|.|..    :|..|
  Rat   187 LRATVRWDYQPDICKDYKETGFCGFGDSCKFLHDRSDYKHGWQIERELDEGRYGVY----EDENY 247

  Fly   252 EIHSDEETLPFKCHICRQSFVNPVVTKCKHYFCEKCALAQYKKSQRCIICSQQTNGIFNPAKELI 316
            |:.||:|.:||||.||||:|.|||||||:|||||.|||..::.:.||.:|.|||||:||||||||
  Rat   248 EVGSDDEEIPFKCFICRQTFQNPVVTKCRHYFCESCALQHFRTTSRCYVCDQQTNGVFNPAKELI 312

  Fly   317 ARLKTNPMENSDSDEEEEFGKKEDKAEAGEEAQEISSDDSD 357
            |:|                ||  .:|||...|.:...|..:
  Rat   313 AKL----------------GK--HRAEAEGAASDFLEDPEE 335

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdlc	NP_650865.1	COG5152	<181..320	CDD:227481	96/138 (70%)
		zf-CCCH	195..221	CDD:279036	24/25 (96%)
		zf-RING_5	263..303	CDD:291308	25/39 (64%)
Rnf113a1	NP_001014791.1	COG5152	58..320	CDD:227481	165/286 (58%)
		zf-CCCH	195..221	CDD:279036	24/25 (96%)
		RING	259..297	CDD:238093	24/37 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345497
Domainoid	1	1.000	180	1.000	Domainoid score	I3432
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H133822
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2069
OMA	1	1.010	-	-		QHG55322
OrthoDB	1	1.010	-	-		D1420266at2759
OrthoFinder	1	1.000	-	-		FOG0003160
OrthoInspector	1	1.000	-	-		oto96385
orthoMCL	1	0.900	-	-		OOG6_102529
Panther	1	1.100	-	-	LDO	PTHR12930
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2126
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.910