DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mdlc and cwf24

DIOPT Version :9

Sequence 1:	NP_650865.1	Gene:	mdlc / 42397	FlyBaseID:	FBgn0038772	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_596257.1	Gene:	cwf24 / 2540186	PomBaseID:	SPBC13E7.02	Length:	533	Species:	Schizosaccharomyces pombe

Alignment Length:	358	Identity:	106/358 - (29%)
Similarity:	169/358 - (47%)	Gaps:	68/358 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KRNLKKGAGIRRKKETSSDE----SAKSSDEETKGKASALVRAENRRKRTNPNFQSTKTMSKAKR 75
            :|..:...|::|||....|:    |::||:|:.:.....:   ..|:|        |..:::.:|
pombe    28 RRRHRPRQGLKRKKGFKRDDDSGGSSESSNEDMRDNIPIV---SGRKK--------TVRLNRLQR 81

  Fly    76 QAGGVGDDGSSSASDDDKLGIAYKSKREALPSGPQDQGATSINEMDTELDRDAQAIHARALKINE 140
            ::    :...:||..|  :.:.|:|...|..........::||| ||                .|
pombe    82 ES----EQFENSALKD--INVEYQSNLSATGESVNTTTVSAINE-DT----------------RE 123

  Fly   141 ELEGKADDK----------IYRGINNYAQYYKKQDTAAGNASSGMVRSGPIRAPAHLRATVRW-- 193
            .:.|:...|          :::..|:|:::..|:......:..|.|.|..       .:|||.
pombe   124 VILGRPSPKLANQSTLPTELFQSQNDYSRFLPKRKDFEKKSQVGPVLSSN-------ASTVRMNT 181

  Fly   194 --DYQPDICKDYKETGYCGFGDSCKFLHDRSDYKAGWQLEMD----HENQRTGDVDSDGDDTKYE 252
              |||||:|||||.|||||:||:|||||.|.||||||||:.:    .|..:.|....:| ..|.|
pombe   182 IIDYQPDVCKDYKLTGYCGYGDTCKFLHMREDYKAGWQLDREWDSVQEKYKKGAKLEEG-MVKNE 245

  Fly   253 IHSDEETLPFKCHICRQSFVNPVVTKCKHYFCEKCALAQYKKSQRCIICSQQTNGIFNPAKELIA 317
               .:|.:||.|.||::.:.:|:.|.|.|:|||:||:.:|:|:..||.|...|.|:|:..|. ..
pombe   246 ---KKEDIPFVCLICKKDYRSPIATTCGHHFCEQCAITRYRKTPTCIQCGADTKGLFSVDKN-FD 306

  Fly   318 RLKTNPMENSDSDEEEEFGKKEDKAEAGEEAQE 350
            ||..|....:|...:::.|..|....|..|..|
pombe   307 RLLKNRKSKNDEAVKQKVGGFESNNSATTEVSE 339

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdlc	NP_650865.1	COG5152	<181..320	CDD:227481	64/146 (44%)
		zf-CCCH	195..221	CDD:279036	21/25 (84%)
		zf-RING_5	263..303	CDD:291308	17/39 (44%)
cwf24	NP_596257.1	COG5152	24..314	CDD:227481	100/331 (30%)
		zf-CCCH	185..211	CDD:279036	21/25 (84%)
		zf-C3HC4_2	254..291	CDD:290634	16/36 (44%)
		RimI	<404..523	CDD:223532
		Acetyltransf_1	425..499	CDD:278980
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	58	1.000	Domainoid score	I3095
eggNOG	1	0.900	-	-		E1_COG5152
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	148	1.000	Inparanoid score	I1317
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003160
OrthoInspector	1	1.000	-	-		oto100892
orthoMCL	1	0.900	-	-		OOG6_102529
Panther	1	1.100	-	-	LDO	PTHR12930
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2079
SonicParanoid	1	1.000	-	-		X2126
TreeFam	1	0.960	-	-
	12	11.850