DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment mdlc and RNF113B

DIOPT Version :9

Sequence 1:	NP_650865.1	Gene:	mdlc / 42397	FlyBaseID:	FBgn0038772	Length:	357	Species:	Drosophila melanogaster
Sequence 2:	NP_849192.1	Gene:	RNF113B / 140432	HGNCID:	17267	Length:	322	Species:	Homo sapiens

Alignment Length:	321	Identity:	156/321 - (48%)
Similarity:	203/321 - (63%)	Gaps:	21/321 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 SEEAASTSSFGFKKRNLKKGAGIRRKK--ETSSDESAKSSDEETKGKASALVRAENRRKRTNPNF 64
            :::|....:|.|||...|..||:|::.  :....||:.|.||   |...|      :..|..|..
Human    11 ADQADQVCTFLFKKPGRKGAAGLRKRPACDPEHGESSSSGDE---GDTVA------QPPRVAPRP 66

  Fly    65 QSTKTMSKAKRQAGGVGDDGSSSASDDDKLGIAYKSKREALPSGPQDQGATSINEMDTELDRDAQ 129
            :...:..||..     ||.....|: .:.|.:.|:|.|.|.|.||:|.|||:..|.|||.:....
Human    67 RGLHSWQKAAH-----GDRRGEEAA-PESLDVVYRSTRSAKPVGPEDMGATADFEQDTEKEHHTP 125

  Fly   130 AIHARALKINEELEGKADDKIYRGINNYAQYYKKQDTAAGNASSGMVRSGPIRAPAHLRATVRWD 194
            .|...:.::.|.|.|:..|.|||||::|.:|.|.:||:.||:||||.|.||||||.|||||||||
Human   126 TILKCSQRVQEALRGREHDHIYRGIHSYLRYLKPKDTSMGNSSSGMARKGPIRAPGHLRATVRWD 190

  Fly   195 YQPDICKDYKETGYCGFGDSCKFLHDRSDYKAGWQLEMDHENQRTGDVDSDGDDTKYEIHSDEET 259
            |||||||||||||:|||||||||||||||||.||::|.:.|..|.    ...:|..:|:.|:||.
Human   191 YQPDICKDYKETGFCGFGDSCKFLHDRSDYKLGWEIERELEEGRY----CICEDENHEVGSEEEE 251

  Fly   260 LPFKCHICRQSFVNPVVTKCKHYFCEKCALAQYKKSQRCIICSQQTNGIFNPAKELIARLK 320
            :||:|.||||:|.|||||||:|||||.|||..::.:.||.||.|.|.|||||||||:|:|:
Human   252 IPFRCFICRQAFQNPVVTKCRHYFCESCALEHFRATPRCYICDQPTGGIFNPAKELMAKLQ 312

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
mdlc	NP_650865.1	COG5152	<181..320	CDD:227481	92/138 (67%)
		zf-CCCH	195..221	CDD:279036	24/25 (96%)
		zf-RING_5	263..303	CDD:291308	25/39 (64%)
RNF113B	NP_849192.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..92		20/82 (24%)
		COG5152	<174..313	CDD:227481	95/143 (66%)
		zf-CCCH	191..217	CDD:279036	24/25 (96%)
		zf-C3HC4_2	256..293	CDD:290634	23/36 (64%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151986
Domainoid	1	1.000	178	1.000	Domainoid score	I3574
eggNOG	1	0.900	-	-		E1_COG5152
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	369	1.000	Inparanoid score	I2145
Isobase	1	0.950	-	0	Normalized mean entropy	S1119
OMA	1	1.010	-	-		QHG55322
OrthoDB	1	1.010	-	-		D1420266at2759
OrthoFinder	1	1.000	-	-		FOG0003160
OrthoInspector	1	1.000	-	-		otm40868
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12930
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2079
SonicParanoid	1	1.000	-	-		X2126
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.850