Protein Alignment Regnase-1 and N4BP1

DIOPT Version :9

• Sequence 1: NP_650863.3
• Gene: Regnase-1 / 42394
• FlyBaseID: FBgn0038769
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_694574.3
• Gene: N4BP1 / 9683
• HGNCID: 29850
• Length: 896
• Species: Homo sapiens
• Alignment Length: 598
• Identity: 158/598 - (26%)
• Similarity: 229/598 - (38%)
• Gaps: 205/598 - (34%)

  Fly    11 EQHKQQQQQQQVHQ----QQQKHGSSN-------KLPVRKQES---------CSDDDESQ--SPS 53
            :.|.||...::..|    .:.|..:||       .:|:.::..         |:.|.|:.  |||
Human   431 QAHTQQNMVEKFSQLPFKVEAKPCTSNCRINTFRTVPIEQKHEVWGSNQNYICNTDPETDGLSPS 495

  Fly    54 -RTTERQNLEFAKKLGYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRPAHIGGGGSPSSM- 116
             .:...:.:.|..:...|.|.........|...:...||...:|...:    ..:|...||.|.
Human   496 VASPSPKEVNFVSRGASSHQPRVPLFPENGLHQQPEPLLPNNMKSACE----KRLGCCSSPHSKP 556

  Fly   117 -TSTLSSP--------------------------TGG---------------SNSSG---LRHIV 136
             .||||.|                          ||.               .|..|   |:|||
Human   557 NCSTLSPPMPLPQLLPSVTDARSAGPSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRTDLKHIV 621

  Fly   137 IDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNNIADQELLYELEHER 201
            |||||||::||....||||||.|.|::|.:.|:|:||.|||.||.. .:.|:.:|..|.:|:...
Human   622 IDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTR-RDPNVTEQHFLTQLQELG 685

  Fly   202 YLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFRRVVQERLLMYSFVN 266
            .|..||:|.:.|:|::.:||||:|.||.:|.||:|:|||:|:.:.||..:|.::.:|||.|:||.
Human   686 ILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVNESVSWREIITKRLLQYTFVG 750

  Fly   267 DIFMPPDDPLGRSGPNLDLFLCSQTQQKMADAQQLCPYGKKCTYGQKCKFRHHNQAPLLQRLP-- 329
            ||||.||||||||||.|:.||  |.:..:.|.|                       |||..||
Human   751 DIFMVPDDPLGRSGPRLEEFL--QKEVCLRDMQ-----------------------PLLSALPNV 790

  Fly   330 --LQASHSAPLHTNGGQQLVSPGGNNNNVKINSLISREPLGRTKSNTIEQVCQGFSAQMDLSEGA 392
              ...|...|     |.|..|             .|.:|..|.                   :||
Human   791 GMFDPSFRVP-----GTQAAS-------------TSHQPPTRI-------------------QGA 818

  Fly   393 VESSQPNRHKKLQRQQPPPAYRLLVPTYSAPLQQQQHQAQQQHQQSNSSTNYHHQYLTRTPSAPV 457
                 |:.|.                     |.||.|                   ....|:.|.
Human   819 -----PSSHW---------------------LPQQPH-------------------FPLLPALPS 838

  Fly   458 TDQGLGLPLPAHNFAHLSASDSRINEELHASQQLPREEQRRLLRYHLGSLFPPHQVHAVLQLYPE 522
            ..|  .||:||..      |.:..||...|..::..:.::||            ::..:|..:|.
Human   839 LQQ--NLPMPAQR------SSAETNELREALLKIFPDSEQRL------------KIDQILVAHPY 883

  Fly   523 ETDAKTICAAILN 535
            ..|...:.|.:|:
Human   884 MKDLNALSAMVLD 896

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	80/155 (52%)
N4BP1	NP_694574.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	403..430
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	488..507		4/18 (22%)
		RNase_Zc3h12a	616..769	CDD:288804	80/153 (52%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	801..821		9/56 (16%)
		CoCUN. /evidence=ECO:0000305|PubMed:31319543	849..896		10/64 (16%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157332
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	6	5.850