DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Regnase-1 and ZC3H12C

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_005271772.1	Gene:	ZC3H12C / 85463	HGNCID:	29362	Length:	884	Species:	Homo sapiens

Alignment Length:	531	Identity:	204/531 - (38%)
Similarity:	275/531 - (51%)	Gaps:	90/531 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 VRKQESCSD--DDESQSPSRTTER---------QNLEFAKKLGYSEQSIHSALTRLGSEAKQNEL 90
            :::.|...|  .:|||:.|:..::         ..||||.||||||:.:...|.:||::|..|::
Human   132 LKRNEILQDFKPEESQTTSKEAKKPPDVVREYQTKLEFALKLGYSEEQVQLVLNKLGTDALINDI 196

  Fly    91 LAELIKLTADAPRPAHIGGGGSPSSMTSTLSSPTGGS--------NSSGLRHIVIDGSNVALSHG 147
            |.||:||...:.....:....:.:..||:|.|....|        :...||.|||||||||:|||
Human   197 LGELVKLGNKSEADQTVSTINTITRETSSLESQRSESPMQEIVTDDGENLRPIVIDGSNVAMSHG 261

  Fly   148 NNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNN--IADQELLYELEHERYLVFTPSRH 210
            |..|||||||::.||||.:|||:|||.|||.||||.:..:  |.|||:|.:||.|:.|||||||.
Human   262 NKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQSRPDALITDQEILRKLEKEKILVFTPSRR 326

  Fly   211 LDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFRRVVQERLLMYSFVNDIFMPPDDP 275
            :.|:||.|||||||:|||.|:|||:|||||||||..|..|:::.:.|||||||||||.|||||||
Human   327 VQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWKKFIDERLLMYSFVNDKFMPPDDP 391

  Fly   276 LGRSGPNLDLFLCSQ---TQQKMADAQQLCPYGKKCTYGQKCKFRHHNQAPLLQRLPLQASHSAP 337
            |||.||:||.||..:   .:.|    :|.||||||||||.|||:.|..:....||  ..|.....
Human   392 LGRHGPSLDNFLRKKPIVPEHK----KQPCPYGKKCTYGHKCKYYHPERGSQPQR--SVADELRA 450

  Fly   338 LHTNGGQQLVSPGGNNNNVKINSLISREPLGRTKSNTIEQVCQGF-SAQMDLSEGA-----VESS 396
            :..|...:..:.||   .||.||:    |.. ||:::...|.:|. ..|.|.|...     :|..
Human   451 MSRNTAAKTANEGG---LVKSNSV----PCS-TKADSTSDVKRGAPKRQSDPSIRTQVYQDLEEK 507

  Fly   397 QPNRHKKLQRQQPP----PAYRLLVPTYSA------------PLQQQQHQAQQQHQQSNSSTNYH 445
            .|.::|...|..|.    ||.....|..:.            |.|.|:.|.|.
Human   508 LPTKNKLETRSVPSLVSIPATSTAKPQSTTSLSNGLPSGVHFPPQDQRPQGQY------------ 560

  Fly   446 HQYLTRTPSAPVTDQGLGLPLPAHNFAHL-SASD----SRINEELHASQQLPREEQRRLLRYHLG 505
                   ||..:..:..|.|:|...:... |..|    |.:|...:.|...||..:||.
Human   561 -------PSMMMATKNHGTPMPYEQYPKCDSPVDIGYYSMLNAYSNLSLSGPRSPERRF------ 612

  Fly   506 SLFPPHQVHAV 516
            ||...:::.:|
Human   613 SLDTDYRISSV 623

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	105/154 (68%)
ZC3H12C	XP_005271772.1	RNase_Zc3h12a	245..401	CDD:288804	106/155 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165157338
Domainoid	1	1.000	224	1.000	Domainoid score	I2564
eggNOG	1	0.900	-	-		E1_KOG3777
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	325	1.000	Inparanoid score	I2490
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40559
orthoMCL	1	0.900	-	-		OOG6_105231
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4205
SonicParanoid	1	1.000	-	-		X1140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.790