DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Regnase-1 and N4bp1

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_085040.2	Gene:	N4bp1 / 80750	MGIID:	2136825	Length:	893	Species:	Mus musculus

Alignment Length:	590	Identity:	162/590 - (27%)
Similarity:	238/590 - (40%)	Gaps:	191/590 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EQHKQQQQQQQVHQ---QQQKHGSSN-------KLPV-RKQE--------SCSDD---DESQSPS 53
            :.|.:|...::..|   :..||.:||       .:|| :|||        ||:.|   |...:.:
Mouse   430 QSHTEQSMVERFSQLPFKDSKHCTSNCKVNSFRTVPVGQKQEIWGSKQNSSCTVDLETDGHSASA 494

  Fly    54 RTTERQNLEFAKKLGYSEQSIHSALTRLGSEAKQNELLAELIK---------LTADAPRP----- 104
            .:...:::.|..:.....|..:.|....|.:.:...||....|         .::..|:|
Mouse   495 ASASPKDISFVSRGASGHQQRNPAFPENGFQQQTEPLLPNNTKPACEKRSGSCSSPQPKPNYPPL 559

  Fly   105 ---------------AHIGGGGS--PSSMT------STLSSP-----TGGSNSSGLRHIVIDGSN 141
                           |.:||...  .||:|      .||..|     ......:.|:||||||||
Mouse   560 SPPLPLPQLLPSVTEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGRADLKHIVIDGSN 624

  Fly   142 VALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNNIADQELLYELEHERYLVFT 206
            ||::||....||||||.|.|::|.:.|:|:||.|||.||.. .:.||.:|..|.:|:....|..|
Mouse   625 VAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTR-RDPNITEQHFLTQLQELGILSLT 688

  Fly   207 PSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFRRVVQERLLMYSFVNDIFMP 271
            |:|.:.|:|::.:||||:|.||.:|.||:|:|||:|:.:.||..:|.::.:|||.|:||.||||.
Mouse   689 PARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKRLLQYTFVGDIFMV 753

  Fly   272 PDDPLGRSGPNLDLFLCSQTQQKMADAQQLCPYGKKCTYGQKCKFRHHNQAPLLQRLPLQASHSA 336
            |||||||:||.|:.||                        :|..|..|.| |||..||
Mouse   754 PDDPLGRNGPRLEEFL------------------------RKEAFLRHMQ-PLLNALP------- 786

  Fly   337 PLHTNGGQQLVSPGGNNNNVKINSLISREPLGRTKSNTIEQVCQGFSAQMDLSEGAVESSQPNRH 401
                                   |:.:.:|..|:.|..:..                     |.|
Mouse   787 -----------------------SVGTFDPGFRSPSTQVAN---------------------NSH 807

  Fly   402 KKLQRQQPPPAYRLLVPTYSAP-LQQQQHQAQQQHQQSNSSTNYHHQYLTRTPSAPVTDQGLGLP 465
                  ||||.    :.|.|:| |.||.|                   .|...:.|...|  ..|
Mouse   808 ------QPPPR----IQTSSSPWLPQQSH-------------------FTALATLPSMQQ--NPP 841

  Fly   466 LPAHNFAHLSASDSRINEELHASQQLPREEQRRLLRYHLGSLFPPHQVHAVLQLYPEETDAKTIC 530
            |||.   ..||..|.:.|.|  .:..|..||:.             ::..:|..:|...|...:.
Mouse   842 LPAQ---RSSAETSELREAL--LKIFPDSEQKL-------------KIDQILAAHPYMKDLNALS 888

  Fly   531 AAILN 535
            |.:|:
Mouse   889 ALVLD 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	79/152 (52%)
N4bp1	NP_085040.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..243
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	273..339
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..433		0/2 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	472..564		13/91 (14%)
		RNase_Zc3h12a	614..767	CDD:288804	80/153 (52%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	793..820		11/57 (19%)
		CoCUN. /evidence=ECO:0000250\|UniProtKB:O75113	846..893		12/61 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847728
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.850