DRSC/TRiP Functional Genomics Resources

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Protein Alignment Regnase-1 and ZC3H12A

DIOPT Version :9

Sequence 1:NP_650863.3 Gene:Regnase-1 / 42394 FlyBaseID:FBgn0038769 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_001310479.1 Gene:ZC3H12A / 80149 HGNCID:26259 Length:599 Species:Homo sapiens


Alignment Length:640 Identity:206/640 - (32%)
Similarity:287/640 - (44%) Gaps:181/640 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly     8 EVQEQHKQQQQQQQVHQQQQKHGSSNKLPVRKQESCSDDDESQSPSRTTERQNLEFAKKLGYSEQ 72
            |.::.|.:|...:...:...:..|:.:|.::                      ::|.:|||||..
Human    21 EFEDSHSRQGTPRPGQELAAEEASALELQMK----------------------VDFFRKLGYSST 63

  Fly    73 SIHSALTRLGSEAKQNELLAELIKLTADAPR------------PAHIGGGGSPSSMTSTLSSPTG 125
            .|||.|.:||.:|..|.:|.||:|......|            |....|||:|.:.......|..
Human    64 EIHSVLQKLGVQADTNTVLGELVKHGTATERERQTSPDPCPQLPLVPRGGGTPKAPNLEPPLPEE 128

  Fly   126 GSNSSGLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNN--I 188
            ....|.||.:||||||||:||||..|||||||.:.|:||.:|||.|||.|||:||||....:  |
Human   129 EKEGSDLRPVVIDGSNVAMSHGNKEVFSCRGILLAVNWFLERGHTDITVFVPSWRKEQPRPDVPI 193

  Fly   189 ADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFRR 253
            .||.:|.|||.::.|||||||.:.||||.|||||||:|||.|:||||||||.||||..|..|::|
Human   194 TDQHILRELEKKKILVFTPSRRVGGKRVVCYDDRFIVKLAYESDGIVVSNDTYRDLQGERQEWKR 258

  Fly   254 VVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQTQQKMADAQQLCPYGKKCTYGQKCKFRH 318
            .::|||||||||||.||||||||||.||:||.|| .:....:...:|.||||:|||||.||:|.|
Human   259 FIEERLLMYSFVNDKFMPPDDPLGRHGPSLDNFL-RKKPLTLEHRKQPCPYGRKCTYGIKCRFFH 322

  Fly   319 HNQAPLLQRLPLQASHSAPLHTNGGQQLVSP---GGNNNNVKINSLISREPLGRTKSNTIEQVCQ 380
            ..:....||     |.:..|..|.   |:||   ...:.|       .|.|...::|:::  :.:
Human   323 PERPSCPQR-----SVADELRANA---LLSPPRAPSKDKN-------GRRPSPSSQSSSL--LTE 370

  Fly   381 GFSAQMDLSEGAVESSQPNRHKKLQRQQPPPAYRLLVPTYSAPLQQQQHQAQQQHQQSNSS---T 442
            .....:|..:...::|..:|.:.| .|...|:.|.|.|:..                |.||   |
Human   371 SEQCSLDGKKLGAQASPGSRQEGL-TQTYAPSGRSLAPSGG----------------SGSSFGPT 418

  Fly   443 NYHHQYLTRTP--SAPVTDQGLGLPLPAHNFAHLSASDSRINE---------------------- 483
            ::..|.|...|  |....|.|:|            :.:|:::|                      
Human   419 DWLPQTLDSLPYVSQDCLDSGIG------------SLESQMSELWGVRGGGPGEPGPPRAPYTGY 471

  Fly   484 -----ELHASQQL--------------------------PRE----------------------- 494
                 ||.|:...                          |||                       
Human   472 SPYGSELPATAAFSAFGRAMGAGHFSVPADYPPAPPAFPPREYWSEPYPLPPPTSVLQEPPVQSP 536

  Fly   495 --------------EQRRLLRYHLGSLFPPHQVHAVLQLYPEETDAKTICAAILN 535
                          :::..:...|..:||||.|.||:..:|:..|.:.:.|.||:
Human   537 GAGRSPWGRAGSLAKEQASVYTKLCGVFPPHLVEAVMGRFPQLLDPQQLAAEILS 591

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Regnase-1NP_650863.3 RNase_Zc3h12a 131..284 CDD:288804 104/154 (68%)
ZC3H12ANP_001310479.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..40 3/18 (17%)
Ubiquitin association domain. /evidence=ECO:0000250|UniProtKB:Q5D1E7 42..87 19/66 (29%)
Necessary for interaction with TANK. /evidence=ECO:0000269|PubMed:25861989 81..150 23/68 (34%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..133 7/42 (17%)
RNase. /evidence=ECO:0000305|PubMed:22561375 112..297 114/185 (62%)
RNase_Zc3h12a 134..290 CDD:288804 105/155 (68%)
RNA binding. /evidence=ECO:0000305|PubMed:22561375 214..220 2/5 (40%)
Necessary for interaction with ZC3H12D. /evidence=ECO:0000269|PubMed:26134560 301..457 48/201 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 343..420 19/102 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 522..546 0/23 (0%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165157336
Domainoid 1 1.000 224 1.000 Domainoid score I2564
eggNOG 1 0.900 - - E1_KOG3777
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 325 1.000 Inparanoid score I2490
Isobase 1 0.950 - 0 Normalized mean entropy S4990
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D335949at33208
OrthoFinder 1 1.000 - - FOG0003961
OrthoInspector 1 1.000 - - otm40559
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12876
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4205
SonicParanoid 1 1.000 - - X1140
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
User_Submission 00.000 Not matched by this tool.
1413.840

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