Protein Alignment Regnase-1 and zc3h12aa

DIOPT Version :10

• Sequence 1: NP_650863.3
• Gene: Regnase-1 / 42394
• FlyBaseID: FBgn0038769
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_021322483.1
• Gene: zc3h12aa / 798235
• ZFINID: ZDB-GENE-110411-6
• Length: 579
• Species: Danio rerio
• Alignment Length: 596
• Identity: 202/596 - (33%)
• Similarity: 286/596 - (47%)
• Gaps: 163/596 - (27%)

  Fly    58 RQNLEFAKKLGYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRP------------AHIGGG 110
            :..::|.:|||||.|.:.:||.:||.....|.:|.||::..|.|..|            :| .||
Zfish    23 QMKVDFFRKLGYSPQEVKAALRKLGLGTDTNAVLGELVRSGAKAVPPSVSNSDDGGSGSSH-RGG 86

  Fly   111 GSPSSMTSTLSSPTGGSNSSGLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAF 175
            ||.....|||...|  ...|.|:.|||||||||:||||..|||||||.:.|::|..||||:||.|
Zfish    87 GSSRGQGSTLDDAT--EAESDLKPIVIDGSNVAMSHGNKEVFSCRGIELAVNYFLDRGHRNITVF 149

  Fly   176 VPNWRKEMANNN--IADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSN 238
            ||:||||....:  |:||.:|.|||.:::|||||||.:.||||.|||||||:|||.:.|||:|||
Zfish   150 VPSWRKEQPRPDVPISDQHILGELERKKFLVFTPSRRVGGKRVVCYDDRFIVKLAHDLDGIIVSN 214

  Fly   239 DNYRDLILESNEFRRVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQTQQKMAD-AQQLC 302
            |.||||..|..|::|.::|||||||||||.||||||||||.|||||.||  :.:..:.| .:|||
Zfish   215 DTYRDLQSERPEWKRFIEERLLMYSFVNDKFMPPDDPLGRHGPNLDNFL--RKKAMLIDHKRQLC 277

  Fly   303 PYGKKCTYGQKCKFRHHNQAPLLQRLPLQASHSAPLHTNGGQQLVSPGGNNNNVKINSLISREPL 367
            |||||||||.||||.|                  |..||..|:.::     :.::.|:.:|
Zfish   278 PYGKKCTYGIKCKFYH------------------PERTNQSQRSLA-----DELRENARLS---- 315

  Fly   368 GRTKSNTIEQVCQGFSAQMDLSEGAVESSQPNRHKKLQRQ---QPPPA-------------YRLL 416
            |..:...:....:|...:.|..     |..|:..::|:::   :|..:             ..:.
Zfish   316 GSKEDCRVSGSLRGVYPRNDPG-----SCSPSLEQELEKKLSLEPESSDSRDVLLHYWDDIMSMK 375

  Fly   417 VPTYSAPLQQQQHQAQQQHQQSNSSTNYHHQYLTRTPSAPVTDQGLGL----------------- 464
            .|..:||:        .|:......|:.|..| ::.||...:|.|||.
Zfish   376 KPLNTAPV--------GQYSALGDRTSLHAPY-SKNPSIFSSDSGLGSYESQFSEQSQSFDELHR 431

  Fly   465 ------PLPA-----------HNFAHLSA------------------------------------ 476
                  |:|.           :|.:|.|:
Zfish   432 IRSGHPPMPGNPAVPAGGHYYNNISHFSSLQPNYTAYSSLPLPNPVQSYSLPACGGWSYPYYLTQ 496

  Fly   477 ---------SDSRINEELHASQQLPR-------EEQRRLLRYHLGSLFPPHQVHAVLQLYPEETD 525
                     |.|..:..::.|||...       :|:|..:|..|.::|.|..|:.|:.::|:..|
Zfish   497 ATGLAEPLTSRSSQSAGVYGSQQHSAMTQSNAFQEEREEVRKKLYAIFNPRHVNKVMDMFPQLKD 561

  Fly   526 AKTICAAILNL 536
            |:.:.|.:|.|
Zfish   562 AQQLAAEVLKL 572

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	UBA_6	61..97	CDD:407876	15/35 (43%)
		PIN_Zc3h12-like	135..263	CDD:350296	82/129 (64%)
		Regnase_1_C	495..534	CDD:465803	12/38 (32%)
zc3h12aa	XP_021322483.1	UBA_6	23..63	CDD:407876	15/39 (38%)
		PIN_Zc3h12-like	109..239	CDD:350296	82/129 (64%)
		zf-CCCH_2	276..294	CDD:464217	16/35 (46%)
		Regnase_1_C	530..573	CDD:465803	14/43 (33%)