DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Regnase-1 and n4bp1

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001004870.1	Gene:	n4bp1 / 448184	XenbaseID:	XB-GENE-1216138	Length:	819	Species:	Xenopus tropicalis

Alignment Length:	447	Identity:	139/447 - (31%)
Similarity:	207/447 - (46%)	Gaps:	86/447 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly     9 VQEQHKQQQQQQQVHQQQQKHGSSNKLPVRKQES---C----SDDDESQSPSRTTERQNLEFAKK 66
            ::|..||.:::..|...|....|::.|..|...|   |    ::..:|.:||:...:..|. ..|
Frog   383 LEEIEKQSKKELSVPFSQSSSYSTDLLKARGTSSLPKCKIAIAETVQSAAPSKVQPKALLA-TDK 446

  Fly    67 LGYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRPAHIGGGGSPSSMTSTLSSPTGG----- 126
            .|.|....:.:.|:   ....|.:..:...:.|.|.|           :..:....|..|
Frog   447 AGPSNPFCYKSQTK---ATVVNPIPTDQTTIVAPAER-----------AFNNHFDPPLTGVQIFQ 497

  Fly   127 -----------SNSSG---LRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVP 177
                       .|..|   |:||:|||||||:|||....||||||.:.|::|.::|||:||.|||
Frog   498 NSLKVQYRLELKNEPGRWDLKHIIIDGSNVAMSHGLQRFFSCRGIALAVEYFWKKGHRNITVFVP 562

  Fly   178 NWRKEMANNNIADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYR 242
            .||.: .:..|.:|..|.:|:....|.|||||.:.|.|::.:||||:|.||..|.||:::|||:|
Frog   563 QWRTK-RDPFITEQHFLQQLQELGILSFTPSRTVLGARIASHDDRFLLHLAERTGGIIITNDNFR 626

  Fly   243 DLILESNEFRRVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQ------------TQQKM 295
            :.::||..:|.:::||||.|:|..||||.|||||||.||.||.||..|            :.::.
Frog   627 EFVVESPSWREIIKERLLQYTFAGDIFMLPDDPLGRYGPKLDDFLSKQPNNRTVHSSFPSSNERF 691

  Fly   296 ADAQQLCPYGKKCTYGQKCKFRHHNQAP---LLQRLPLQASHSAPLHTNGG-QQLVSPGGNNNNV 356
            ....|..|              ..|.||   |.|.:..:|.|:.|:....| .|.::|....:..
Frog   692 VPRDQFAP--------------PRNMAPKTGLNQPMAPRAGHNQPMAPRAGHNQPMAPRTGLSQH 742

  Fly   357 KINSLIS-REPLGRTKSNTIEQVC------QGFSAQMDLSEGAV----ESSQPNRHK 402
            :...||. :||......| |.:.|      :..|..|.|.|..:    |:.|  |||
Frog   743 RFLQLIKPQEPFTPALHN-IARPCPIMPPERSPSETMQLKEALLKIFPEADQ--RHK 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	80/155 (52%)
n4bp1	NP_001004870.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..20
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	226..247
		PIN_N4BP1-like	520..646	CDD:350295	62/126 (49%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	666..736		17/83 (20%)
		CoCUN. /evidence=ECO:0000250\|UniProtKB:O75113	772..819		9/27 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.020