DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Regnase-1 and n4bp1

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_956081.2	Gene:	n4bp1 / 327327	ZFINID:	ZDB-GENE-030131-5538	Length:	858	Species:	Danio rerio

Alignment Length:	358	Identity:	126/358 - (35%)
Similarity:	180/358 - (50%)	Gaps:	62/358 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CEV-----QEQHKQQQQQQQVHQQQQK---------HGSSNKL-PVRKQESCSDDDESQSPS-RT 55
            |||     :|...:.:::.::.....|         .|||..: |||.:...:....||.|. ||
Zfish   475 CEVIIIDDEEDFTETERKPRLTPLDLKPESRFDYLPRGSSQTMVPVRMETVTNLRSSSQGPPLRT 539

  Fly    56 TERQNLEFAKKLGYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRPAHIGGGGSPSSMTSTL 120
            ::       .:.|.|.|::........|||:.....|.|..:                |....:|
Zfish   540 SD-------TRPGCSYQTLPGRAPLPRSEAQYTSKAAPLTGM----------------SRFQQSL 581

  Fly   121 SSP-----TGGSNSSGLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWR 180
            .:|     .....|..||||:|||||||::||.:.|||||||.|.|:.|.:||||:||.|||.||
Zfish   582 RTPYRLILQNEPGSPNLRHIIIDGSNVAMAHGLHRVFSCRGIAIAVEAFWRRGHREITVFVPQWR 646

  Fly   181 KEMANNNIADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLI 245
            :: .:.||.:|..|.:||:.|.|.|||||.:.|.|:|.:||||:|.||.:|.|::|:|||.||.:
Zfish   647 QK-KDPNITEQHFLNQLENLRLLSFTPSREVCGHRISSHDDRFLLHLAEKTGGVIVTNDNLRDFV 710

  Fly   246 LESNEFRRVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQTQQKMADAQQLCP------Y 304
            .:|..:||::.||||.::||.|.||.||||||:.||:||.||...::     ...:.|      .
Zfish   711 SQSEAWRRIIHERLLQFTFVEDHFMIPDDPLGKHGPHLDEFLLKDSR-----GSPIIPPLRTDLR 770

  Fly   305 GKKCTYGQKCKFRHHNQAPLLQRLPLQASHSAP 337
            .....|.|..:...|..:|  ...|    ||.|
Zfish   771 ATPSVYSQAAQSTAHPSSP--SHWP----HSGP 797

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	85/152 (56%)
n4bp1	NP_956081.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	17..37
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	262..321
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	388..424
		RNase_Zc3h12a	597..750	CDD:288804	86/153 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	774..823		8/30 (27%)
		CoCUN. /evidence=ECO:0000250\|UniProtKB:O75113	813..858
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170593107
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.850