DRSC/TRiP Functional Genomics Resources

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Protein Alignment Regnase-1 and Zc3h12b

DIOPT Version :9

Sequence 1:NP_650863.3 Gene:Regnase-1 / 42394 FlyBaseID:FBgn0038769 Length:540 Species:Drosophila melanogaster
Sequence 2:XP_002730294.1 Gene:Zc3h12b / 296864 RGDID:1560891 Length:835 Species:Rattus norvegicus


Alignment Length:575 Identity:203/575 - (35%)
Similarity:283/575 - (49%) Gaps:81/575 - (14%)


- Green bases have known domain annotations that are detailed below.


  Fly    13 HKQQQ----QQQQVHQQQQKHGSSNKLPVRKQESCSDDDESQSPSRTTERQ---NLEFAKKLGYS 70
            |...|    |.::.....:.|....:.|...:.|.|.....|......|::   .::||.||||:
  Rat    56 HNSNQSADIQLKKKEMPSKPHRPLCRSPCLDRPSFSQSSILQDGKLDLEKEYQAKMDFALKLGYA 120

  Fly    71 EQSIHSALTRLGSEAKQNELLAELIKLTADAPRPAHIGGGGSPSSMTSTLSSPTGGS-------- 127
            |:.|.|.|.:||.|:..|::||||::|.         ..|.|.:.:..:|..|.|.|        
  Rat   121 EEQIQSVLNKLGPESLINDVLAELVRLG---------NKGDSEAQVNLSLLLPRGASSREIASPE 176

  Fly   128 --------NSSGLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMA 184
                    ||..||.:||||||||:||||...||||||::.||||..:||:|||.|||.||||.:
  Rat   177 LSLEDEIDNSDNLRPVVIDGSNVAMSHGNKEEFSCRGIQLAVDWFLDKGHKDITVFVPAWRKEQS 241

  Fly   185 NNN--IADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILE 247
            ..:  |.||::|.:||.|:.|||||||.:.|:||.|||||||:|||.::|||:|||||||||.:|
  Rat   242 RPDAPITDQDILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFDSDGIIVSNDNYRDLQVE 306

  Fly   248 SNEFRRVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQ---TQQKMADAQQLCPYGKKCT 309
            ..|:::.::|||||||||||.||||||||||.||:|:.||..:   .:.|    :|.||||||||
  Rat   307 KPEWKKFIEERLLMYSFVNDKFMPPDDPLGRHGPSLENFLRKRPVVPEHK----KQPCPYGKKCT 367

  Fly   310 YGQKCKFRHHNQAPLLQR-LPLQASHSAPLHT---NGGQQLVSPGGNNNNVK--INSLISREPLG 368
            ||.|||:.|..:|...|| :..:...||.|.|   .....|...|...:..|  |.|.|.|....
  Rat   368 YGHKCKYYHPERANQPQRSVADELRISAKLSTVKIMSEDTLAKCGTGMSTAKGEITSEIKRVASK 432

  Fly   369 RTKSNTIEQVCQGFSAQMDLSEGAVESSQPNRHKKLQRQQ-PPPAYR----LLVPTYSAPLQQQQ 428
            |....:|..|.......:.::.....||.|:....|.... |||...    |...:.|:|:....
  Rat   433 RQSDPSIRSVAVEPEEWLSIARKPEASSVPSLVTALSVPTIPPPKSHAVGALNTRSASSPVPGSS 497

  Fly   429 H----QAQQQHQQSNS-----STNYHHQYLTRTPSAPVTDQGLGLPLPAHNFAHLSASDSRIN-E 483
            |    :|..:|..|..     .||.|...:..|...|..:     .:..|::..:.:..|::: .
  Rat   498 HFPHQKASLEHMVSMQYPPILVTNSHGTPINYTEQYPKFE-----TMGDHDYYSVLSDFSKLSIN 557

  Fly   484 ELHASQQLPREEQRRLLRYHLGSLFPPHQVH--------------AVLQLYPEET 524
            .:|..:....|..:.:...:.|.....|..|              ||...:||.|
  Rat   558 NMHNHEYYMAEANQGVYVRNPGLCTDSHMSHTRNDNYSSYNNLYLAVADAHPEGT 612

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Regnase-1NP_650863.3 RNase_Zc3h12a 131..284 CDD:288804 100/154 (65%)
Zc3h12bXP_002730294.1 UBA_6 107..148 CDD:407876 18/40 (45%)
PIN_Zc3h12-like 192..322 CDD:350296 80/129 (62%)
zf-CCCH_4 359..377 CDD:407881 13/17 (76%)
Regnase_1_C 795..829 CDD:408345
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C166351298
Domainoid 1 1.000 224 1.000 Domainoid score I2468
eggNOG 1 0.900 - - E1_KOG3777
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 328 1.000 Inparanoid score I2379
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D335949at33208
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 1 1.000 - - otm44695
orthoMCL 1 0.900 - - OOG6_105231
Panther 1 1.100 - - O PTHR12876
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1140
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1312.760

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