DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Regnase-1 and N4bp1

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001292110.1	Gene:	N4bp1 / 291921	RGDID:	1305179	Length:	893	Species:	Rattus norvegicus

Alignment Length:	605	Identity:	153/605 - (25%)
Similarity:	232/605 - (38%)	Gaps:	222/605 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 EQHKQQQQQQQVHQ---QQQKHGSSN-------KLPV---------RKQESCSDDDE-------S 49
            :.|.:|...::..|   :..|..:||       .:||         ::..:|:.|.|       |
  Rat   431 QNHTEQTMVERFSQLPFKDSKQCTSNCRINSFKTVPVGQKHEIWASKQNSNCTVDLETDGVLAAS 495

  Fly    50 QSPSRTTERQNLEFAKKLGYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRPA---HIGGGG 111
            .||      :::.|..:.....|..:||....|.:.:...||...:|       ||   ..||.|
  Rat   496 ASP------KDVSFVSRGALGHQQRNSAFLENGFQQQAEPLLPNNVK-------PACEKRSGGCG 547

  Fly   112 SPSS-----------------MTSTLSSPTGGS---------------------------NSSG- 131
            ||..                 :.|...:..|||                           |..|
  Rat   548 SPQPKPNYHPPLSPPLPPPQLLPSATEARLGGSSDHIDSSVTGVQRFRDTLKIPYKLELKNEPGR 612

  Fly   132 --LRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNNIADQELL 194
              |:||||||||||::||....||||||.|.|::|.:.|:|:||.|||.||.. .:.||.:|..|
  Rat   613 ADLKHIVIDGSNVAITHGLKKFFSCRGIAIAVEYFWKLGNRNITVFVPQWRTR-RDPNITEQHFL 676

  Fly   195 YELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFRRVVQERL 259
            .:|:....|..||:|.:.|:|::.:||||:|.||.:|.||:|:|||:|:.:.||..:|.::.:||
  Rat   677 TQLQELGILSLTPARMVFGERIASHDDRFLLHLADKTGGIIVTNDNFREFVTESVSWREIITKRL 741

  Fly   260 LMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQTQQKMADAQQLCPYGKKCTYGQKCKFRHHNQAPL 324
            |.|:||.||||.|||||||:||.|:.||  :.:..:.|.|                       ||
  Rat   742 LQYTFVGDIFMVPDDPLGRNGPRLEEFL--RKEVFLRDMQ-----------------------PL 781

  Fly   325 LQRLPLQASHSAPLHTNGGQQLVSPGGNNNNVKINSLISREPLGRTKSNTIEQVCQGFSAQMDLS 389
            |..||                                                           |
  Rat   782 LNALP-----------------------------------------------------------S 787

  Fly   390 EGAVESSQPNRHKKLQRQQPPPAYRLLVPTYSAPLQQQQHQAQQQHQQSNSSTNYHHQYLTR--- 451
            .|..:                       |.:.:|..|..:.:.|...:..:|:|:   :|.:
  Rat   788 VGTFD-----------------------PGFRSPSTQVANTSHQPPSRIQTSSNH---WLPQQPH 826

  Fly   452 -TPSAPVTDQGLGLPLPAHNFAHLSASDSRINEELHASQQLPREEQRRLLRYHLGSLFPPHQVHA 515
             ||.|.:......||:||.   ..||..|.:.|.|  .:..|..||:.             ::..
  Rat   827 FTPLATLPSMQQNLPVPAQ---RSSAETSELREAL--LKIFPDSEQKL-------------KIDQ 873

  Fly   516 VLQLYPEETDAKTICAAILN 535
            :|..:|...|...:.|.:|:
  Rat   874 ILVAHPYMKDLNALSALVLD 893

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	80/155 (52%)
N4bp1	NP_001292110.1	KH-I_N4BP1_like_rpt1	8..73	CDD:411808
		KH-I_N4BP1	75..142	CDD:411904
		PIN_N4BP1-like	618..744	CDD:350295	61/126 (48%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351300
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3777
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.850