DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Regnase-1 and Nynrin

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001035161.1	Gene:	Nynrin / 277154	MGIID:	2652872	Length:	1840	Species:	Mus musculus

Alignment Length:	446	Identity:	126/446 - (28%)
Similarity:	185/446 - (41%)	Gaps:	105/446 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 SSNKLPVRKQESCSDDDESQSPSRTTERQNLEFAKK------LGYSEQSIHSALTRL-GSEAKQN 88
            |.|:..:.|.:........|..|....|...:|.|:      .|....|.||..|.: .|..:.|
Mouse   656 SKNRAIMLKVQGKPGRQGFQPSSTVPSRSKHQFLKEGLLGAWEGSQRLSPHSQGTNIVTSFQRYN 720

  Fly    89 ELLAELIKLTADAPRPAHIGGGGSPSSMTSTLSSPTGGSNSSGLRHIVIDGSNVALSHGNNLVFS 153
            |.|                   .:|..|  .||...|   :.|||.:|||||:||:.||....||
Mouse   721 EAL-------------------NTPFEM--NLSEEPG---NPGLRRVVIDGSSVAMVHGLQHFFS 761

  Fly   154 CRGIRICVDWFRQRGHRDITAFVPNWRKEMANNNIADQELLYELEHERYLVFTPSRHLDGKRVSC 218
            ||||.:.|.:|..||||:||.|||.|:.: .|..:.:...|.:|...:.|..|||:..:||:::.
Mouse   762 CRGIAMAVQYFWNRGHREITVFVPTWQLK-KNRRVRESHFLTKLHRLKMLSITPSQLENGKKITT 825

  Fly   219 YDDRFILKLAVETDGIVVSNDNYRDLILESNEFRRVVQERLLMYSFVNDIFMPPDDPLGRSGPNL 283
            ||.||::|||.||||::|:|:...  ||.:|..:.:|::|||.::|...:||.|||||||.||.|
Mouse   826 YDYRFMVKLAEETDGVIVTNEQIH--ILMNNSKKLMVKDRLLPFTFAGSLFMVPDDPLGRDGPTL 888

  Fly   284 DLFLCSQTQQKMADAQQLCPYGKKCTYGQKCKFRHHNQAPLLQRLPLQASHSAPLHTNG-GQQLV 347
            :.||....:..|...                     |...:.:.||..::..:.|..:. .:.|.
Mouse   889 EEFLKKPNRLDMDIG---------------------NFLKVWKTLPPSSASISELSDDADAEPLE 932

  Fly   348 SPGGNNNNVKINSLISREPLGRTKSNTIEQ-----------VCQGFSAQM-------DLSEGAVE 394
            .|.......|....:..|| |..|.:..::           .|..||.::       |.|||.::
Mouse   933 DPQDVEEAGKEEGSLEEEP-GIPKPDEEDEQDTNPVSVFGVECPSFSEEILQCLSLHDPSEGTLD 996

  Fly   395 SSQPNRHKKLQRQQPPPAYRLLVPTYS-----------APLQQQQHQAQQQHQQSN 439
            ..                   |:|..|           ||.||...|..|.:..||
Mouse   997 ID-------------------LLPVVSSPYLDVPWDGKAPCQQVLAQLAQLNIPSN 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	71/152 (47%)
Nynrin	NP_001035161.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	249..327
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	427..449
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	545..564
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	574..615
		RNase_Zc3h12a	739..890	CDD:288804	72/153 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	918..968		8/50 (16%)
		RNase_H_like	1104..1207	CDD:301345
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1125..1149
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847722
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.950