DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Regnase-1 and Zc3h12c

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	NP_001156393.1	Gene:	Zc3h12c / 244871	MGIID:	3026959	Length:	903	Species:	Mus musculus

Alignment Length:	562	Identity:	214/562 - (38%)
Similarity:	287/562 - (51%)	Gaps:	102/562 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CEVQEQHKQQQQQQQVHQQQQKHGSSNKLPVRKQESCSDDDESQSPSRTTER---------QNLE 62
            |.:.:.|:|..:...:..:..||  |:.|...|.|      |||:||:..::         ..||
Mouse   131 CSLTKTHRQLCRSPCLEPRLLKH--SDILQDFKPE------ESQTPSKEVKKPPDVVREYQTKLE 187

  Fly    63 FAKKLGYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRPAHIGGGGSPSSMTSTLSSPTGGS 127
            ||.||||||:.:...|.:||::|..|::|.||:||...:.....:....|....||:|.|....|
Mouse   188 FALKLGYSEEQVQLVLNKLGTDALINDILGELVKLGNKSEADQTVSTINSVMRETSSLESQRSES 252

  Fly   128 --------NSSGLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMA 184
                    :...||.:||||||||:||||..|||||||::.||||.:|||:|||.|||.||||.:
Mouse   253 PMQEVVVDDGENLRPVVIDGSNVAMSHGNKEVFSCRGIKLAVDWFLERGHKDITVFVPAWRKEQS 317

  Fly   185 NNN--IADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILE 247
            ..:  |.|||:|.:||.|:.|||||||.:.|:||.|||||||:|||.|:|||:|||||||||..|
Mouse   318 RPDALITDQEILRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANE 382

  Fly   248 SNEFRRVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQ---TQQKMADAQQLCPYGKKCT 309
            ..|:::.:.|||||||||||.||||||||||.||:||.||..:   .:.|    :|.||||||||
Mouse   383 KPEWKKFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPIVPEHK----KQPCPYGKKCT 443

  Fly   310 YGQKCKFRHHNQAPLLQR-----LPLQASHSAPLHTNGGQQLVSPGGNNNNVKINSLISREPLGR 369
            ||.|||:.|..:....||     |...:.::|...||.|          ..||.||:    |..
Mouse   444 YGHKCKYYHPERGSQPQRSVADELRAMSRNTAAKTTNEG----------GLVKSNSV----PCS- 493

  Fly   370 TKSNTIEQVCQGF-SAQMDLSEGA-----VESSQPNRHKKLQRQQPP----PAYRLLVPTYSAPL 424
            ||:::...|.:|. ..|.|.|...     :|...|.::|...|..|.    ||.....|..:.||
Mouse   494 TKADSTSDVKRGAPKRQSDPSIRTHVYQDIEEKLPTKNKLETRSVPSLVSIPATSTAKPQSTTPL 558

  Fly   425 QQ----------QQHQAQQQHQQSNSSTNYHHQYLTRTPSAPVTDQGLGLPLPAHNFAHL-SASD 478
            ..          |..:.|.|:.....:|..|                 |.|:|...:... |..|
Mouse   559 SNGLPSGVHFPPQDQRPQGQYPPMMMATKNH-----------------GTPMPYEQYPKCDSPVD 606

  Fly   479 ----SRINEELHASQQLPREEQRRLLRYHLGSLFPPHQVHAV 516
                |.:|...:.|...||..:||.      ||...::|::|
Mouse   607 VGYYSMLNAYSNLSISGPRSPERRF------SLDTDYRVNSV 642

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	104/154 (68%)
Zc3h12c	NP_001156393.1	RNase_Zc3h12a	264..420	CDD:288804	105/155 (68%)
Zc3h12c	NP_001156393.1	PHA03160	<519..762	CDD:165431	31/147 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847734
Domainoid	1	1.000	224	1.000	Domainoid score	I2541
eggNOG	1	0.900	-	-		E1_KOG3777
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	328	1.000	Inparanoid score	I2439
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42629
orthoMCL	1	0.900	-	-		OOG6_105231
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4205
SonicParanoid	1	1.000	-	-		X1140
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.790