DRSC/TRiP Functional Genomics Resources

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Protein Alignment Regnase-1 and Zc3h12a

DIOPT Version :9

Sequence 1:NP_650863.3 Gene:Regnase-1 / 42394 FlyBaseID:FBgn0038769 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_694799.1 Gene:Zc3h12a / 230738 MGIID:2385891 Length:596 Species:Mus musculus


Alignment Length:605 Identity:220/605 - (36%)
Similarity:293/605 - (48%) Gaps:134/605 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 QQKHGSSNKLPVRKQESCSDDDESQSPSRTTERQ-NLEFAKKLGYSEQSIHSALTRLGSEAKQNE 89
            :.:|.|..    |.|   .|.|.....:.|:|.| .::|.:|||||...|||.|.:||.:|..|.
Mouse    23 EDRHSSQG----RPQ---PDQDPVAKEAPTSELQMKVDFFRKLGYSSSEIHSVLQKLGVQADTNT 80

  Fly    90 LLAELIK-----------LTADAPRPAHIGGGGS-PSSMTSTLSSPTGGSNSSGLRHIVIDGSNV 142
            :|.||:|           |||.:|:|..:..||| |...|...|.|......|.||.:|||||||
Mouse    81 VLGELVKHGSATERECQALTAPSPQPPLVPRGGSTPKPSTLEPSLPEEDREGSDLRPVVIDGSNV 145

  Fly   143 ALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNN--IADQELLYELEHERYLVF 205
            |:||||..|||||||.:.|:||.:|||.|||.|||:||||....:  |.||.:|.|||.::.|||
Mouse   146 AMSHGNKEVFSCRGILLAVNWFLERGHTDITVFVPSWRKEQPRPDVPITDQHILRELEKKKILVF 210

  Fly   206 TPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFRRVVQERLLMYSFVNDIFM 270
            ||||.:.||||.|||||||:|||.|:||:|||||.||||..|..|::|.::|||||||||||.||
Mouse   211 TPSRRVGGKRVVCYDDRFIVKLAFESDGVVVSNDTYRDLQGERQEWKRFIEERLLMYSFVNDKFM 275

  Fly   271 PPDDPLGRSGPNLDLFLCSQTQQKMADAQ---QLCPYGKKCTYGQKCKFRHHNQAPLLQRLPLQA 332
            ||||||||.||:||.||    ::|...::   |.||||||||||.||:|.|              
Mouse   276 PPDDPLGRHGPSLDNFL----RKKPLPSEHRKQPCPYGKKCTYGIKCRFFH-------------- 322

  Fly   333 SHSAPLHTNGGQQLVSPGGNNNNVKINSLIS--REPLGRTKSNTIEQVCQGFSAQMDLSEGAVES 395
                |...:..|:.|:     :.::.|:|:|  |.|:....|.......|..|..::...|:::.
Mouse   323 ----PERPSRPQRSVA-----DELRANALLSPPRTPVKDKSSQRPSPASQSSSVSLEAEPGSLDG 378

  Fly   396 ------SQPNRHKKLQRQQPPPAYRLLV-------PT-YSAPLQQQQHQAQQQ-------HQQSN 439
                  |.|..|::...|...||.|.|.       || :.|..|.......|:       ..:|.
Mouse   379 KKLGARSSPGPHREGSPQTCAPAGRSLPVSGGSFGPTEWLAHTQDSLPYTSQECLDSGIGSLESQ 443

  Fly   440 SSTNY-------------------HHQYLTRTPSAPVTDQGLGLPL-PAHNFAHLSASDSRI--- 481
            .|..:                   :|.|.::.|:||...     |. ||....|.|.....:   
Mouse   444 MSELWGVRGGSPGESGPTRGPYAGYHSYGSKVPAAPSFS-----PFRPAMGAGHFSVPTDYVPPP 503

  Fly   482 -----NEELHASQQLP------REEQR--------------RLLRYHLG------SLFPPHQVHA 515
                 .|.......||      :|.||              .|.:...|      .:||||.|.|
Mouse   504 PTYPSREYWSEPYPLPPPTPVLQEPQRPSPGAGGGPWGRVGDLAKERAGVYTKLCGVFPPHLVEA 568

  Fly   516 VLQLYPEETDAKTICAAILN 535
            |::.:|:..|.:.:.|.||:
Mouse   569 VMRRFPQLLDPQQLAAEILS 588

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Regnase-1NP_650863.3 RNase_Zc3h12a 131..284 CDD:288804 103/154 (67%)
Zc3h12aNP_694799.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..48 7/31 (23%)
Ubiquitin association domain. /evidence=ECO:0000305|PubMed:21115689 42..87 20/44 (45%)
Necessary for interaction with TANK. /evidence=ECO:0000250|UniProtKB:Q5D1E8 81..150 28/68 (41%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 97..134 12/36 (33%)
RNase. /evidence=ECO:0000250|UniProtKB:Q5D1E8 112..281 105/168 (63%)
RNase_Zc3h12a 134..290 CDD:288804 104/155 (67%)
RNA binding. /evidence=ECO:0000250|UniProtKB:Q5D1E8 214..220 2/5 (40%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 278..306 14/31 (45%)
Necessary for interaction with ZC3H12D. /evidence=ECO:0000250|UniProtKB:Q5D1E8 301..454 42/175 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 340..417 19/76 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 511..543 5/31 (16%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C167847732
Domainoid 1 1.000 224 1.000 Domainoid score I2541
eggNOG 1 0.900 - - E1_KOG3777
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 328 1.000 Inparanoid score I2439
Isobase 1 0.950 - 0 Normalized mean entropy S4990
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0003961
OrthoInspector 1 1.000 - - otm42629
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - LDO PTHR12876
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R4205
SonicParanoid 1 1.000 - - X1140
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1413.830

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