Protein Alignment Regnase-1 and rege-1

DIOPT Version :9

• Sequence 1: NP_650863.3
• Gene: Regnase-1 / 42394
• FlyBaseID: FBgn0038769
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: NP_491985.4
• Gene: rege-1 / 172426
• WormBaseID: WBGene00016260
• Length: 634
• Species: Caenorhabditis elegans
• Alignment Length: 602
• Identity: 183/602 - (30%)
• Similarity: 276/602 - (45%)
• Gaps: 169/602 - (28%)

  Fly    42 SCSD------DDESQSPSRTTERQN-----------LEFAKKLGYSEQSIHSALTRLGSEAKQNE 89
            ||.|      ..||..||:..:.|.           :|||.|||||.:.:...|..:|.:::.::
 Worm    85 SCDDISHPSLSRESSDPSKIDDDQTAPMIRYPAPEVVEFATKLGYSTEQLSHVLNTIGVDSRMDD 149

  Fly    90 LLAELIKLTADAPRPAHIGGGGSPSS----MTSTLSSPTGGSNSS-------------------- 130
            :|:||:|:.....:|.:.|..||.:|    |||:.||.:..|:||
 Worm   150 VLSELVKMGLPGGKPENSGKSGSRNSPEPIMTSSASSSSASSSSSHRPIRQSVSIATSSPATSSS 214

  Fly   131 ---------GLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEM--A 184
                     .||.:|:||||||:.||...||||.|:|.|:::|.:|||.::..|:|.:|:|.  :
 Worm   215 TPSKYNPDPSLRAVVVDGSNVAMLHGRKEVFSCAGLRECLNYFLERGHPEVLIFIPQYRREQPRS 279

  Fly   185 NNNIADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESN 249
            ::.|.||.:|.|:  ||::::||||:::|:||.|:|||:||:.|...|.::||||.||||..|:.
 Worm   280 DSPITDQHILQEI--ERHIIYTPSRNVNGRRVVCHDDRYILRTAELKDAVIVSNDEYRDLTRENP 342

  Fly   250 EFRRVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQTQQKMADAQQL-CPYGKKCTYGQK 313
            .:|::|:|||||::||.|.|||||||.||.||.::.||   ::..:..:..| |||.:|||||.|
 Worm   343 AWRKIVEERLLMFTFVEDKFMPPDDPSGRHGPRIESFL---SKVPVVSSNPLVCPYARKCTYGNK 404

  Fly   314 CKFRHHNQAPLLQRLPLQASHSAPLHTNGGQQLVSPGGNNNNVKINSLISREPLGRTKSNTIEQV 378
            |||.|..:|                             |..::.:...:.:|
 Worm   405 CKFYHPERA-----------------------------NGQHMSVTERLMKE------------- 427

  Fly   379 CQGFSAQMDLSEGAVESSQ----PNRHKKLQRQQ----------------PPPAYRLLVPTYSAP 423
                 .|...|.|||:|.|    .|:|..|.|.|                |.|...:.:|.....
 Worm   428 -----NQQKKSLGAVKSMQYEMFKNKHAALSRTQSLNVVKQLTENMSQLPPTPESPMQMPRQHMQ 487

  Fly   424 LQQ------QQHQAQQQHQQS----------------NSSTNYHHQYL---------TRTPSAPV 457
            |||      |||...|:|..|                |.|...:||.|         .|.|....
 Worm   488 LQQANSAPWQQHTVVQRHGSSPLTPVNRQMNVYPDMYNMSQQQNHQVLPNQHGVIGGQRPPKMTT 552

  Fly   458 TDQGLGLPLPA-----HNFAHLSASDSRINEELHASQQLPREEQRRLLRYHLGSLFPPHQVHAVL 517
            |.....|..|:     |:...:...::..:|.|        .|.|..:.:||.::||...|.:|:
 Worm   553 TVSQTHLFAPSTAVWGHSELSVGPVNTGSDESL--------AEVRSRVHFHLCNIFPHDFVESVM 609

  Fly   518 QLYPEETDAKTICAAIL 534
            ...|||.:|..:|..|:
 Worm   610 AANPEEVNAPVLCELII 626

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	78/154 (51%)
rege-1	NP_491985.4	RNase_Zc3h12a	224..377	CDD:314796	78/154 (51%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166838
Domainoid	1	1.000	173	1.000	Domainoid score	I2221
eggNOG	1	0.900	-	-		E1_KOG3777
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	262	1.000	Inparanoid score	I1900
Isobase	1	0.950	-	0	Normalized mean entropy	S4990
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	1	1.000	-	-		FOG0003961
OrthoInspector	1	1.000	-	-		oto20273
orthoMCL	1	0.900	-	-		OOG6_105231
Panther	1	1.100	-	-	LDO	PTHR12876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4205
SonicParanoid	1	1.000	-	-		X1140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740