Protein Alignment Regnase-1 and zc3h12c

DIOPT Version :10

• Sequence 1: NP_650863.3
• Gene: Regnase-1 / 42394
• FlyBaseID: FBgn0038769
• Length: 540
• Species: Drosophila melanogaster
• Sequence 2: XP_002938007.2
• Gene: zc3h12c / 100490495
• XenbaseID: XB-GENE-6045328
• Length: 884
• Species: Xenopus tropicalis
• Alignment Length: 783
• Identity: 235/783 - (30%)
• Similarity: 324/783 - (41%)
• Gaps: 275/783 - (35%)

  Fly     7 CEVQEQHKQQQQQQQVHQQQQKHGSSNKL--PVRKQESCSDDDESQSPSRTTE--RQNLEFAKKL 67
            |.|.::|:|..:...:.....|.   |::  .::.:::.:...|.:.|....:  :..|:||.||
 Frog   114 CRVTKKHRQFCRSPCIDPYILKR---NEVIQDLKTEDNVASTKEIKKPPDVVKEYQTKLDFALKL 175

  Fly    68 GYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRPAHIGGGGSPSSMTSTLSSPTGGS----- 127
            ||||:.:...|.:|||.|..|::|.||:||.:.:......||.|:....||::.|....|
 Frog   176 GYSEEQVLLVLNKLGSNALINDILGELVKLGSKSDNEQSGGGNGAVLRETSSIESQRPESPFQQE 240

  Fly   128 ---NSSGLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNN-- 187
               ::..||.|||||||||:||||..|||||||::.|.||.:|||:|:|.|||.||||.:..:
 Frog   241 LIDDTENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVSWFLERGHKDVTVFVPAWRKEQSRPDAL 305

  Fly   188 IADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFR 252
            |.|||:|.:||.|:.|||||||.:.|:||.|||||||:|||.|:|||:|||||||||..|..|::
 Frog   306 ITDQEVLRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWK 370

  Fly   253 RVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQ---TQQKMADAQQLCPYGKKCTYGQKC 314
            :.:.|||||||||||.||||||||||.||:||.||..:   .:.|    :|.||||||||||.||
 Frog   371 KFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPVVPEYK----KQPCPYGKKCTYGHKC 431

  Fly   315 KFRH----------------------------------HNQAP---------------------- 323
            |:.|                                  .|..|
 Frog   432 KYYHPERGSQPQRSVADELRAMSRSSAAKTASEVGLVKSNSVPSSTKMDTNYDLKRSTPKRQSDP 496

  Fly   324 --------LLQRLPLQ---ASHSAP----LHTNGGQQ-------------------------LVS 348
                    |..:||.:   .|.|.|    :.||..|.                         |.|
 Frog   497 SIRTQAYDLEDKLPTKNKFESRSVPSLVSISTNKPQSTPQTPLSNGILSAGHLSSQEKALPALYS 561

  Fly   349 PG--GNNN------------------------NVKINSLIS--REPLGRTKSNT---IEQVCQGF 382
            ||  ...|                        |...|..||  |.|..|...:|   |..|....
 Frog   562 PGLMSTKNPSAMSCDQYPQCDSPVDAGYYSMMNAYSNLSISGARSPERRFSLDTDYRISSVASDC 626

  Fly   383 SAQMDLSEGA------------VESSQPNRHKKLQRQQPPPAYRLLVPTYSA----PLQQQQ--- 428
            |::..||.|:            |.|..|...:.::.|...|..|..:.||.:    ||.:.|
 Frog   627 SSEGSLSCGSSDSYVGYNDRSHVSSPDPQLDENIKCQHMHPHTRSGLQTYMSCYHEPLTRVQSFG 691

  Fly   429 HQAQQQHQQSNSSTNYHHQ----YLTRTP-------------------SAPVTDQGL-------- 462
            |:.:|:|         ||:    |::..|                   ::||:..|:
 Frog   692 HEQEQKH---------HHKPQSPYMSGPPQHLTVAARSSCPNDYRISQNSPVSRNGIMGRSLVST 747

  Fly   463 -----------GLPLPAHNFAHLSASDSRINEELHASQQ-------------------------- 490
                       ..|.|.|:..:||...:|..|..:....
 Frog   748 RMESISDSRLYESPPPRHHKPYLSQEATRSWERPYGMDSYGYCQNYSVSSNPSQPCYDQFAFQSP 812

  Fly   491 --------------LPREEQRRLLRYHLG----------SLFPPHQVHAVLQLYPEETDAKTICA 531
                          ||:|..    ||.||          ::||...|..|::..|..|||:.:.|
 Frog   813 PDHQDNSWRIPYCGLPQEPP----RYPLGTREKVFLNLCNIFPAELVQLVMKRNPHVTDAQQLAA 873

  Fly   532 AIL 534
            |||
 Frog   874 AIL 876

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	UBA_6	61..97	CDD:407876	18/35 (51%)
		PIN_Zc3h12-like	135..263	CDD:350296	83/129 (64%)
		Regnase_1_C	495..534	CDD:465803	14/48 (29%)
zc3h12c	XP_002938007.2	UBA_6	165..206	CDD:407876	19/40 (48%)
		PIN_Zc3h12-like	251..381	CDD:350296	83/129 (64%)
		zf-CCCH_2	418..436	CDD:464217	13/17 (76%)
		Regnase_1_C	839..879	CDD:465803	12/38 (32%)