DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Regnase-1 and zc3h12c

DIOPT Version :9

Sequence 1:	NP_650863.3	Gene:	Regnase-1 / 42394	FlyBaseID:	FBgn0038769	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_002938007.2	Gene:	zc3h12c / 100490495	XenbaseID:	XB-GENE-6045328	Length:	884	Species:	Xenopus tropicalis

Alignment Length:	783	Identity:	235/783 - (30%)
Similarity:	324/783 - (41%)	Gaps:	275/783 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 CEVQEQHKQQQQQQQVHQQQQKHGSSNKL--PVRKQESCSDDDESQSPSRTTE--RQNLEFAKKL 67
            |.|.::|:|..:...:.....|.   |::  .::.:::.:...|.:.|....:  :..|:||.||
Frog   114 CRVTKKHRQFCRSPCIDPYILKR---NEVIQDLKTEDNVASTKEIKKPPDVVKEYQTKLDFALKL 175

  Fly    68 GYSEQSIHSALTRLGSEAKQNELLAELIKLTADAPRPAHIGGGGSPSSMTSTLSSPTGGS----- 127
            ||||:.:...|.:|||.|..|::|.||:||.:.:......||.|:....||::.|....|
Frog   176 GYSEEQVLLVLNKLGSNALINDILGELVKLGSKSDNEQSGGGNGAVLRETSSIESQRPESPFQQE 240

  Fly   128 ---NSSGLRHIVIDGSNVALSHGNNLVFSCRGIRICVDWFRQRGHRDITAFVPNWRKEMANNN-- 187
               ::..||.|||||||||:||||..|||||||::.|.||.:|||:|:|.|||.||||.:..:
Frog   241 LIDDTENLRPIVIDGSNVAMSHGNKEVFSCRGIKLAVSWFLERGHKDVTVFVPAWRKEQSRPDAL 305

  Fly   188 IADQELLYELEHERYLVFTPSRHLDGKRVSCYDDRFILKLAVETDGIVVSNDNYRDLILESNEFR 252
            |.|||:|.:||.|:.|||||||.:.|:||.|||||||:|||.|:|||:|||||||||..|..|::
Frog   306 ITDQEVLRKLEKEKILVFTPSRRVQGRRVVCYDDRFIVKLAFESDGIIVSNDNYRDLANEKPEWK 370

  Fly   253 RVVQERLLMYSFVNDIFMPPDDPLGRSGPNLDLFLCSQ---TQQKMADAQQLCPYGKKCTYGQKC 314
            :.:.|||||||||||.||||||||||.||:||.||..:   .:.|    :|.||||||||||.||
Frog   371 KFIDERLLMYSFVNDKFMPPDDPLGRHGPSLDNFLRKKPVVPEYK----KQPCPYGKKCTYGHKC 431

  Fly   315 KFRH----------------------------------HNQAP---------------------- 323
            |:.|                                  .|..|
Frog   432 KYYHPERGSQPQRSVADELRAMSRSSAAKTASEVGLVKSNSVPSSTKMDTNYDLKRSTPKRQSDP 496

  Fly   324 --------LLQRLPLQ---ASHSAP----LHTNGGQQ-------------------------LVS 348
                    |..:||.:   .|.|.|    :.||..|.                         |.|
Frog   497 SIRTQAYDLEDKLPTKNKFESRSVPSLVSISTNKPQSTPQTPLSNGILSAGHLSSQEKALPALYS 561

  Fly   349 PG--GNNN------------------------NVKINSLIS--REPLGRTKSNT---IEQVCQGF 382
            ||  ...|                        |...|..||  |.|..|...:|   |..|....
Frog   562 PGLMSTKNPSAMSCDQYPQCDSPVDAGYYSMMNAYSNLSISGARSPERRFSLDTDYRISSVASDC 626

  Fly   383 SAQMDLSEGA------------VESSQPNRHKKLQRQQPPPAYRLLVPTYSA----PLQQQQ--- 428
            |::..||.|:            |.|..|...:.::.|...|..|..:.||.:    ||.:.|
Frog   627 SSEGSLSCGSSDSYVGYNDRSHVSSPDPQLDENIKCQHMHPHTRSGLQTYMSCYHEPLTRVQSFG 691

  Fly   429 HQAQQQHQQSNSSTNYHHQ----YLTRTP-------------------SAPVTDQGL-------- 462
            |:.:|:|         ||:    |::..|                   ::||:..|:
Frog   692 HEQEQKH---------HHKPQSPYMSGPPQHLTVAARSSCPNDYRISQNSPVSRNGIMGRSLVST 747

  Fly   463 -----------GLPLPAHNFAHLSASDSRINEELHASQQ-------------------------- 490
                       ..|.|.|:..:||...:|..|..:....
Frog   748 RMESISDSRLYESPPPRHHKPYLSQEATRSWERPYGMDSYGYCQNYSVSSNPSQPCYDQFAFQSP 812

  Fly   491 --------------LPREEQRRLLRYHLG----------SLFPPHQVHAVLQLYPEETDAKTICA 531
                          ||:|..    ||.||          ::||...|..|::..|..|||:.:.|
Frog   813 PDHQDNSWRIPYCGLPQEPP----RYPLGTREKVFLNLCNIFPAELVQLVMKRNPHVTDAQQLAA 873

  Fly   532 AIL 534
            |||
Frog   874 AIL 876

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Regnase-1	NP_650863.3	RNase_Zc3h12a	131..284	CDD:288804	103/154 (67%)
zc3h12c	XP_002938007.2	UBA_6	165..206	CDD:375509	19/40 (48%)
		PIN_Zc3h12-like	251..381	CDD:350296	83/129 (64%)
		zf-CCCH_4	418..436	CDD:375512	13/17 (76%)
		Regnase_1_C	839..879	CDD:375987	12/38 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	221	1.000	Domainoid score	I2552
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D335949at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm47733
Panther	1	1.100	-	-	O	PTHR12876
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4205
SonicParanoid	1	1.000	-	-		X1140
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.050