DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and Zscan29

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001277748.1	Gene:	Zscan29 / 99334	MGIID:	2139317	Length:	834	Species:	Mus musculus

Alignment Length:	560	Identity:	132/560 - (23%)
Similarity:	209/560 - (37%)	Gaps:	121/560 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SEKDLTHMIREC-------GGVPIKQFDHYPDKICEKC---FKVLKMAFKF------RETC---- 86
            |:.:....:|.|       |.|..:..::...:..|:|   ||.|:.:::.      .:||
Mouse   254 SQTEFYEALRNCHRNSQVYGAVAGRLREYGFLRTLEQCRTKFKGLQKSYRKVKSGHPPDTCPFFE 318

  Fly    87 ------------------QRSYGHLRQFVGPVEVEQRPPEK-----KGSETATKLEPDVDPDEAE 128
                              :.:..|..|.....|.| :|.::     .|.|...:.....||:...
Mouse   319 EMEALMSAQVISLPINGLEEAASHSAQAGSDAETE-KPGQRDWQHEDGEEAIAERSDSDDPEATP 382

  Fly   129 QEPEHD----------------EEDED--VDLDESHYAEA----DDAAETQGGVFHDEIEDGILV 171
            |:|::.                ||.:.  ..|.|:.:.||    ...::..|.|.....|.|.|.
Mouse   383 QDPDNPPAPVLFRSPSGVHWGYEETKTYLAILSETQFYEALQNCHRNSQLYGTVAERLWEYGFLR 447

  Fly   172 ELEKDRIV---------HVKNEQVEEDGIIEEVYDVYETYEGDLIPDQGYDHEMADQALSELS-A 226
            ..|:.|..         .|||.|..|.....|..|...:.:....|....:.|.....|...| |
Mouse   448 TPEQCRTKFKSLQTSYRKVKNGQALETCPFFEEMDALVSAQVAAPPSDDQEKETVSCCLQRTSEA 512

  Fly   227 EIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSV--RASIHARNATKRRVNPRRSATSTA 289
            |.|..|:   |...:|..|||.|          :|.::|  ||.:..::.:...........|..
Mouse   513 EPEKQDE---DTEEDSDDEDDTE----------IPPEAVITRAPVLFQSPSGFEAGFENEENSKR 564

  Fly   290 SVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMSIKSEK----------------DISIGEVLARK 338
            .::.|....:|....:..|:....:.|..||....||.                :.:||:||..:
Mouse   565 DISEEVQLHRTLLARSERKISHHVNQSKASKNKCSSESQWEKTQREEQRQLAFPEKNIGKVLTYQ 629

  Fly   339 HSGI-----------KTKGGHKIL---LGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHE 389
            ..|:           |:.|.:..|   :..:.|..|.|..||..:...:||..|.::|:|.||::
Mouse   630 RPGLEDRPYKYVKYGKSSGSNSHLRYPVSHEVENPYKCADCGKSFSRSARLIRHQRIHTGEKPYK 694

  Fly   390 CEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFT 454
            |..||..|..:.....|...|||.:||:|..|...|...|:...|.|.||.|:||:|:.|.|:|.
Mouse   695 CLDCGKGFRDSSNFITHRRIHTGEKPYQCDECGKRFNQSSSLIIHQRTHTGEKPYQCEECGKSFN 759

  Fly   455 YTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            .::....|:.|||||:||||..|||.|.::..|..|...|
Mouse   760 NSSHFNAHRRIHTGERPHVCPDCGKSFSKSSDLHAHHRTH 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	13/90 (14%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	10/23 (43%)
		COG5048	386..>447	CDD:227381	23/60 (38%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	8/22 (36%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
Zscan29	NP_001277748.1	SCAN	13..123	CDD:128708
		SCAN	13..101	CDD:280241
		Myb_DNA-bind_4	238..319	CDD:290549	12/64 (19%)
		Myb_DNA-bind_4	399..480	CDD:290549	18/80 (23%)
		COG5048	<663..823	CDD:227381	53/137 (39%)
		zf-C2H2	665..687	CDD:278523	7/21 (33%)
		C2H2 Zn finger	667..687	CDD:275368	6/19 (32%)
		zf-H2C2_2	680..702	CDD:290200	9/21 (43%)
		C2H2 Zn finger	695..715	CDD:275368	5/19 (26%)
		zf-H2C2_2	707..732	CDD:290200	9/24 (38%)
		C2H2 Zn finger	723..743	CDD:275368	6/19 (32%)
		zf-H2C2_2	735..760	CDD:290200	11/24 (46%)
		C2H2 Zn finger	751..771	CDD:275368	5/19 (26%)
		zf-H2C2_2	763..787	CDD:290200	13/23 (57%)
		zf-C2H2	777..799	CDD:278523	9/21 (43%)
		C2H2 Zn finger	779..799	CDD:275368	7/19 (37%)
		C2H2 Zn finger	807..827	CDD:275368
		zf-C2H2	807..827	CDD:278523
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4340
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050