DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4936 and ZNF254

DIOPT Version :9

Sequence 1:NP_650862.1 Gene:CG4936 / 42393 FlyBaseID:FBgn0038768 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_975011.3 Gene:ZNF254 / 9534 HGNCID:13047 Length:659 Species:Homo sapiens


Alignment Length:200 Identity:77/200 - (38%)
Similarity:111/200 - (55%) Gaps:22/200 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   322 SIKSEKDISIGEVLAR---------KHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTE 377
            ::.:.|.|.:||.|.:         :.|.:.|   |||:...:|.:|  |:.||..:...|.||:
Human   392 TLTTHKIIHVGEKLYKCEECGKGFNRSSNLTT---HKIIHTGEKPYK--CEECGKAFIWSSTLTK 451

  Fly   378 HIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNER 442
            |.::|:..||::||.||..|..:..|.||...|||.:||||..|..:|:..||...|..|||.|:
Human   452 HKRIHTREKPYKCEECGKAFIWSSTLTRHKRMHTGEKPYKCEECGKSFSQSSTLTTHKIIHTGEK 516

  Fly   443 PYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH--------ERRGQ 499
            ||:|:.|.|.|.:::||..||:|||.|||:.|:.|||.|.|:..|.||:.||        |..|:
Human   517 PYKCEECGKAFNWSSTLTKHKIIHTEEKPYKCEKCGKAFKQSSILTNHKRIHTGEKPYKCEECGK 581

  Fly   500 SARES 504
            |...|
Human   582 SFNRS 586

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4936NP_650862.1 zf-AD 22..95 CDD:214871
C2H2 Zn finger 362..382 CDD:275368 7/19 (37%)
zf-H2C2_2 375..399 CDD:290200 11/23 (48%)
COG5048 386..>447 CDD:227381 28/60 (47%)
C2H2 Zn finger 390..410 CDD:275368 8/19 (42%)
zf-H2C2_2 403..426 CDD:290200 11/22 (50%)
C2H2 Zn finger 418..438 CDD:275368 6/19 (32%)
zf-H2C2_2 432..455 CDD:290200 11/22 (50%)
C2H2 Zn finger 446..466 CDD:275368 8/19 (42%)
zf-H2C2_2 459..481 CDD:290200 13/21 (62%)
C2H2 Zn finger 474..494 CDD:275368 9/19 (47%)
ZNF254NP_975011.3 KRAB 13..73 CDD:214630
C2H2 Zn finger 184..204 CDD:275368
C2H2 Zn finger 212..260 CDD:275368
COG5048 264..625 CDD:227381 76/199 (38%)
C2H2 Zn finger 268..288 CDD:275368
C2H2 Zn finger 296..316 CDD:275368
C2H2 Zn finger 324..344 CDD:275368
C2H2 Zn finger 352..372 CDD:275368
C2H2 Zn finger 380..400 CDD:275368 1/7 (14%)
C2H2 Zn finger 408..428 CDD:275368 5/22 (23%)
C2H2 Zn finger 436..456 CDD:275368 7/19 (37%)
C2H2 Zn finger 464..484 CDD:275368 8/19 (42%)
C2H2 Zn finger 492..512 CDD:275368 6/19 (32%)
C2H2 Zn finger 520..540 CDD:275368 8/19 (42%)
C2H2 Zn finger 548..568 CDD:275368 9/19 (47%)
C2H2 Zn finger 576..596 CDD:275368 3/10 (30%)
C2H2 Zn finger 604..624 CDD:275368
C2H2 Zn finger 632..652 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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