DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF160

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001096073.1	Gene:	ZNF160 / 90338	HGNCID:	12948	Length:	818	Species:	Homo sapiens

Alignment Length:	234	Identity:	80/234 - (34%)
Similarity:	115/234 - (49%)	Gaps:	32/234 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   268 SIHARNATKRRVNPRRSATSTASVAVESST---SKTTDRGNPLKVRRGNS----DSAGSKMSIKS 325
            |:|:..||.:.::     |.|........:   ::.:...|..::..|..    :..|...|::|
Human   463 SMHSNLATHQVIH-----TGTKPFKCNECSKVFTQNSQLANHRRIHTGEKPYKCNECGKAFSVRS 522

  Fly   326 EKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHEC 390
              .::..:.:   |||               |..|.|..||..:..:|.|..|..:|||.||::|
Human   523 --SLTTHQAI---HSG---------------EKPYKCIECGKSFTQKSHLRSHRGIHSGEKPYKC 567

  Fly   391 EICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTY 455
            ..||..|||..|||||...|||.:||||:.|..||:|.|:...|..|||.|:||:|..|.|.|.:
Human   568 NECGKVFAQTSQLARHWRVHTGEKPYKCNDCGRAFSDRSSLTFHQAIHTGEKPYKCHECGKVFRH 632

  Fly   456 TNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            .:.|..|:.|||||||:.|:.|||.|.....|..|:|||
Human   633 NSYLATHRRIHTGEKPYKCNECGKAFSMHSNLTTHKVIH 671

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	32/60 (53%)
		C2H2 Zn finger	390..410	CDD:275368	11/19 (58%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZNF160	NP_001096073.1	KRAB	8..68	CDD:214630
		KRAB	8..47	CDD:279668
		zf-C2H2	257..279	CDD:278523
		C2H2 Zn finger	259..279	CDD:275368
		zf-H2C2_2	271..295	CDD:290200
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200
		C2H2 Zn finger	315..335	CDD:275368
		zf-H2C2_2	327..350	CDD:290200
		C2H2 Zn finger	343..363	CDD:275368
		zf-H2C2_2	355..380	CDD:290200
		COG5048	367..810	CDD:227381	80/234 (34%)
		C2H2 Zn finger	371..391	CDD:275368
		C2H2 Zn finger	399..419	CDD:275368
		zf-H2C2_2	411..436	CDD:290200
		C2H2 Zn finger	427..447	CDD:275368
		zf-H2C2_2	439..463	CDD:290200	80/234 (34%)
		C2H2 Zn finger	455..475	CDD:275368	4/11 (36%)
		C2H2 Zn finger	483..503	CDD:275368	1/19 (5%)
		zf-H2C2_2	496..519	CDD:290200	3/22 (14%)
		C2H2 Zn finger	511..531	CDD:275368	3/24 (13%)
		zf-H2C2_2	523..548	CDD:290200	8/42 (19%)
		C2H2 Zn finger	539..559	CDD:275368	6/19 (32%)
		zf-H2C2_2	551..576	CDD:290200	11/24 (46%)
		C2H2 Zn finger	567..587	CDD:275368	11/19 (58%)
		C2H2 Zn finger	595..615	CDD:275368	7/19 (37%)
		zf-H2C2_2	607..632	CDD:290200	11/24 (46%)
		C2H2 Zn finger	623..643	CDD:275368	6/19 (32%)
		zf-H2C2_2	635..659	CDD:290200	13/23 (57%)
		C2H2 Zn finger	651..671	CDD:275368	8/19 (42%)
		zf-H2C2_2	663..688	CDD:290200	5/9 (56%)
		C2H2 Zn finger	679..699	CDD:275368
		zf-H2C2_2	691..715	CDD:290200
		C2H2 Zn finger	707..727	CDD:275368
		zf-H2C2_2	719..744	CDD:290200
		C2H2 Zn finger	735..755	CDD:275368
		zf-H2C2_2	747..770	CDD:290200
		C2H2 Zn finger	763..783	CDD:275368
		zf-H2C2_2	775..800	CDD:290200
		C2H2 Zn finger	791..811	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910