DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF322

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001229726.1	Gene:	ZNF322 / 79692	HGNCID:	23640	Length:	402	Species:	Homo sapiens

Alignment Length:	182	Identity:	66/182 - (36%)
Similarity:	97/182 - (53%)	Gaps:	18/182 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   337 RKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQ 401
            |.|:|              |:| |.||:||..:...|.|..|.:.|:|.||:.|..|..||:::.
Human   119 RTHAG--------------KKF-YTCDICGKNFGQSSDLLVHQRSHTGEKPYLCSECDKCFSRST 168

  Fly   402 QLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIH 466
            .|.||..||||.:|:||..|..||:..|....|.|.||.||||:|:.|.|::.:.:....||.:|
Human   169 NLIRHRRTHTGEKPFKCLECEKAFSGKSDLISHQRTHTGERPYKCNKCEKSYRHRSAFIVHKRVH 233

  Fly   467 TGEKPHVCDVCGKGFPQAYKLRNHRVIHERRGQSARESVAGLVSYD-TANIV 517
            |||||:.|..|.|.|.|...|..|:.:|  .|:...:.:..:.|:. :||::
Human   234 TGEKPYKCGACEKCFGQKSDLIVHQRVH--TGEKPYKCLECMRSFTRSANLI 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	10/23 (43%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		zf-H2C2_2	459..481	CDD:290200	11/21 (52%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZNF322	NP_001229726.1	C2H2 Zn finger	45..65	CDD:275368
		COG5048	<69..219	CDD:227381	45/114 (39%)
		C2H2 Zn finger	73..93	CDD:275368
		C2H2 Zn finger	101..121	CDD:275368	1/1 (100%)
		C2H2 Zn finger	129..149	CDD:275368	7/19 (37%)
		C2H2 Zn finger	157..177	CDD:275368	7/19 (37%)
		C2H2 Zn finger	185..205	CDD:275368	7/19 (37%)
		SFP1	<207..291	CDD:227516	27/79 (34%)
		C2H2 Zn finger	213..233	CDD:275368	5/19 (26%)
		C2H2 Zn finger	241..261	CDD:275368	7/19 (37%)
		C2H2 Zn finger	269..289	CDD:275368	3/15 (20%)
		C2H2 Zn finger	295..315	CDD:275368
		C2H2 Zn finger	353..373	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910