Protein Alignment idc and ZNF16

DIOPT Version :10

• Sequence 1: NP_650862.1
• Gene: idc / 42393
• FlyBaseID: FBgn0038768
• Length: 521
• Species: Drosophila melanogaster
• Sequence 2: NP_008889.2
• Gene: ZNF16 / 7564
• HGNCID: 12947
• Length: 682
• Species: Homo sapiens
• Alignment Length: 481
• Identity: 123/481 - (25%)
• Similarity: 191/481 - (39%)
• Gaps: 149/481 - (30%)

  Fly   139 DVDLDE--SHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYDVYET 201
            |.:|:.  .||.:.|....|:...|                   :..|.:.||  :|...::.|.
Human    52 DTELEAICPHYQQPDCDTRTEDKEF-------------------LHKEDIHED--LESQAEISEN 95

  Fly   202 YEGDL--IPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHED----------------DA 248
            |.||:  :|:.|   ::.|. :||....:.     |..:|.:|..::                :.
Human    96 YAGDVSQVPELG---DLCDD-VSERDWGVP-----EGRRLPQSLSQEGDFTPAAMGLLRGPLGEK 151

  Fly   249 EVDLNSTEEEFVPSKSVRASIHARNATKRRVNP--------RRSATSTASVAVESSTSK------ 299
            ::|.|..:..|..|.::.|.  ....|:.|.:|        :.|...|....|.::.|.
Human   152 DLDCNGFDSRFSLSPNLMAC--QEIPTEERPHPYDMGGQSFQHSVDLTGHEGVPTAESPLICNEC 214

  Fly   300 -TTDRGNP-----------------------------LKVR-------------------RGNSD 315
             .|.:|||                             ||.|                   ||:||
Human   215 GKTFQGNPDLIQRQIVHTGEASFMCDDCGKTFSQNSVLKNRHRSHMSEKAYQCSECGKAFRGHSD 279

  Fly   316 SAGSKMSIKSEKDI---SIGEVLARKHSGIKTKGGH-------------------------KILL 352
            .:..:....||:..   ..|:..::..|..|.:..|                         :|..
Human   280 FSRHQSHHSSERPYMCNECGKAFSQNSSLKKHQKSHMSEKPYECNECGKAFRRSSNLIQHQRIHS 344

  Fly   353 GDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYK 417
            |:|   .|:|..||..:...|.|.:|.:.|:|.||.||..||..|:|:..|.:|...|||.:||:
Human   345 GEK---PYVCSECGKAFRRSSNLIKHHRTHTGEKPFECGECGKAFSQSAHLRKHQRVHTGEKPYE 406

  Fly   418 CSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFP 482
            |:.|...|:.:|...||||:||.|:||:|..|.|.|:.:::|..|:.||||||||||:||||.|.
Human   407 CNDCGKPFSRVSNLIKHHRVHTGEKPYKCSDCGKAFSQSSSLIQHRRIHTGEKPHVCNVCGKAFS 471

  Fly   483 QAYKLRNHRVIHERRGQSA-RESVAG 507
            .:..||.|::||  .|:.. |.||.|
Human   472 YSSVLRKHQIIH--TGEKPYRCSVCG 495

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
idc	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		SFP1	<424..491	CDD:227516	34/66 (52%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		C2H2 Zn finger	474..494	CDD:275368	9/19 (47%)
ZNF16	NP_008889.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..43
		Necessary for transcription activation	62..210		32/179 (18%)
		COG5048	<160..369	CDD:227381	37/213 (17%)
		C2H2 Zn finger	187..203	CDD:275368	2/15 (13%)
		C2H2 Zn finger	211..231	CDD:275368	4/19 (21%)
		C2H2 Zn finger	239..259	CDD:275368	3/19 (16%)
		C2H2 Zn finger	267..287	CDD:275368	4/19 (21%)
		Required for nuclear localization	268..393		30/127 (24%)
		C2H2 Zn finger	295..315	CDD:275368	3/19 (16%)
		COG5048	303..675	CDD:227381	74/198 (37%)
		C2H2 Zn finger	323..343	CDD:275368	0/19 (0%)
		Required for nuclear localization	341..373		11/34 (32%)
		C2H2 Zn finger	351..371	CDD:275368	6/19 (32%)
		C2H2 Zn finger	379..399	CDD:275368	7/19 (37%)
		C2H2 Zn finger	407..427	CDD:275368	8/19 (42%)
		C2H2 Zn finger	435..455	CDD:275368	6/19 (32%)
		C2H2 Zn finger	463..483	CDD:275368	9/19 (47%)
		Required for nuclear localization	473..503		10/25 (40%)
		C2H2 Zn finger	491..511	CDD:275368	3/5 (60%)
		C2H2 Zn finger	519..539	CDD:275368
		C2H2 Zn finger	547..567	CDD:275368
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	603..623	CDD:275368
		C2H2 Zn finger	631..651	CDD:275368
		C2H2 Zn finger	659..679	CDD:275368