DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4936 and Zfp397

DIOPT Version :9

Sequence 1:NP_650862.1 Gene:CG4936 / 42393 FlyBaseID:FBgn0038768 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_081283.2 Gene:Zfp397 / 69256 MGIID:1916506 Length:527 Species:Mus musculus


Alignment Length:538 Identity:128/538 - (23%)
Similarity:201/538 - (37%) Gaps:154/538 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    28 QQPKEPMASIFNDDSEKDLTHMIRECGGVPIKQFDHYPDKICEKCFKVLKMAFKFRET--CQRSY 90
            |..:|.:..:..:||....:...::.|..          :.|::.|:.....|.:.||  .:.:.
Mouse    14 QDHQEELILVKIEDSSFSWSQKCKQNGSA----------QSCQELFRQQFRKFCYHETPGPREAL 68

  Fly    91 GHLR------------------------QFVG--PVE----VEQRPPEKKGSETATKLEPDVD-- 123
            |.|:                        ||:.  |.|    |:|..| |.|.|..|.|| |::  
Mouse    69 GRLQELCHQWLMPELHTKEQILELLVLEQFLSILPEELKIWVQQHGP-KSGEEAVTLLE-DLEKE 131

  Fly   124 -PDEAEQEPEHDEEDEDVDLDESHYAEADDAAETQGGVFHDEIED-GILVELEKDRIVHVKNEQV 186
             .|..:|.|::.:.......|.::...:.|:...|......:::. ...:..:.|.   ..||..
Mouse   132 FDDPGQQVPDNLQGPSVSWKDLTYLKTSQDSTSIQVRPLKTQLKSWNPCLSSKSDA---KNNEST 193

  Fly   187 EEDGIIEEVYDVYETYEGDLIPDQGYDHEMADQALSELSAEIEY-----------LDQV--EHDQ 238
            .::.|.||           ..|:..:|...  :.:||..:.:|:           ..||  .|..
Mouse   194 AKEDISEE-----------KAPELSWDPSC--RGVSEHKSNLEWQQRSSPVHRGSFSQVIFTHKS 245

  Fly   239 LTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNATKRRVNPRRSATSTASVAVESSTSKTTDR 303
            |.:..|.|:::                                |....||.||..:..:  |.||
Mouse   246 LAKRDHLDESQ--------------------------------RCLIISTNSVTCQKVS--TDDR 276

  Fly   304 -------GNPLK----------VRRGNS----DSAGSKMSIKSEKDISIGEVLARK-HSGIKTKG 346
                   |:..|          :..|..    :..|...|::|..      ::.:| |||.|.  
Mouse   277 PYRCDVCGHSFKQHFSLTQHQRIHTGEKPYKCNQCGKAFSLRSYL------IIHQKIHSGEKA-- 333

  Fly   347 GHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHT 411
                         |.|:.||..:...|.||.|.|:|:|.|..:|..||..|:|:..|..|...||
Mouse   334 -------------YECNECGKAFNQSSALTRHRKIHTGEKACKCNECGKAFSQSSYLIIHQRIHT 385

  Fly   412 GNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDV 476
            |.:||.||.|...|:..|...:|.||||.||||||:.|.|.|..::.|..|:.||:||||:.|:.
Mouse   386 GEKPYGCSECGKTFSQSSKLIRHQRIHTGERPYECNECGKAFKQSSELITHQRIHSGEKPYECNE 450

  Fly   477 CGKGFPQAYKLRNHRVIH 494
            |||.|.....|..|:.||
Mouse   451 CGKAFSLNSNLIRHQRIH 468

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4936NP_650862.1 zf-AD 22..95 CDD:214871 12/92 (13%)
C2H2 Zn finger 362..382 CDD:275368 8/19 (42%)
zf-H2C2_2 375..399 CDD:290200 11/23 (48%)
COG5048 386..>447 CDD:227381 28/60 (47%)
C2H2 Zn finger 390..410 CDD:275368 7/19 (37%)
zf-H2C2_2 403..426 CDD:290200 10/22 (45%)
C2H2 Zn finger 418..438 CDD:275368 7/19 (37%)
zf-H2C2_2 432..455 CDD:290200 14/22 (64%)
C2H2 Zn finger 446..466 CDD:275368 6/19 (32%)
zf-H2C2_2 459..481 CDD:290200 12/21 (57%)
C2H2 Zn finger 474..494 CDD:275368 7/19 (37%)
Zfp397NP_081283.2 SCAN 46..152 CDD:128708 23/107 (21%)
COG5048 <264..520 CDD:227381 76/228 (33%)
C2H2 Zn finger 280..300 CDD:275368 2/19 (11%)
C2H2 Zn finger 308..328 CDD:275368 4/25 (16%)
C2H2 Zn finger 336..356 CDD:275368 8/19 (42%)
C2H2 Zn finger 364..384 CDD:275368 7/19 (37%)
C2H2 Zn finger 392..412 CDD:275368 7/19 (37%)
C2H2 Zn finger 420..440 CDD:275368 6/19 (32%)
C2H2 Zn finger 448..468 CDD:275368 7/19 (37%)
C2H2 Zn finger 476..496 CDD:275368
C2H2 Zn finger 504..524 CDD:275368
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 151 1.000 Inparanoid score I4340
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
11.050

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