DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4936 and ZKSCAN7

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001275519.1	Gene:	ZKSCAN7 / 55888	HGNCID:	12955	Length:	754	Species:	Homo sapiens

Alignment Length:	599	Identity:	139/599 - (23%)
Similarity:	218/599 - (36%)	Gaps:	179/599 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 HYPDK------ICEKCFKVLKMAFKFRETCQRSYGHLRQFVGPVEVEQRPPEKK---GSETATKL 118
            |:|:.      :.|...:.|..:.:.....|:...|..:.......::.||...   ||.....|
Human   117 HHPESGEEAVAVVEDFQRHLSGSEEVSAPAQKQEMHFEETTALGTTKESPPTSPLSGGSAPGAHL 181

  Fly   119 EPDVDP---------------------------DEAEQ------EPEHDEEDEDVDLD------- 143
            ||..||                           |:|..      .|:.....||:.:|
Human   182 EPPYDPGTHHLPSGDFAQCTSPVPTLPQVGNSGDQAGATVLRMVRPQDTVAYEDLSVDYTQKKWK 246

  Fly   144 ---------------ESHYAEADDAAE-----------------------TQGGVF--------- 161
                           |:|::.|..|.|                       |.||:|
Human   247 SLTLSQRALQWNMMPENHHSMASLAGENMMKGSELTPKQEFFKGSESSNRTSGGLFGVVPGAAET 311

  Fly   162 HDEIED------GILVELEKDRIVHVKNEQVEED--GIIEEVYDVYE-------------TYEGD 205
            .|..||      |...:.|..|:.:...|..:||  ...::.||.|:             .:||.
Human   312 GDVCEDTFKELEGQTSDEEGSRLENDFLEITDEDKKKSTKDRYDKYKEVGEHPPLSSSPVEHEGV 376

  Fly   206 LIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIH 270
            |...:.|..:...:|.:..|      ..:.|.::    |..:...:.|...:.|  .::.:..:|
Human   377 LKGQKSYRCDECGKAFNRSS------HLIGHQRI----HTGEKPYECNECGKTF--RQTSQLIVH 429

  Fly   271 ARNAT-----------------------KRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRG 312
            .|..|                       :|..|..:...........:.:|:.||.
Human   430 LRTHTGEKPYECSECGKAYRHSSHLIQHQRLHNGEKPYKCNECAKAFTQSSRLTDH--------- 485

  Fly   313 NSDSAGSKMSIKSEKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTE 377
            .....|.|....:|    .||...|.    |:...|::|...||.:|  |:.||..:.|...|.:
Human   486 QRTHTGEKPYECNE----CGEAFIRS----KSLARHQVLHTGKKPYK--CNECGRAFCSNRNLID 540

  Fly   378 HIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNER 442
            |.::|:|.||:||..||..|::::.|.||.:.|||.:|||||.|..||...|...:|.||||.|:
Human   541 HQRIHTGEKPYECSECGKAFSRSKCLIRHQSLHTGEKPYKCSECGKAFNQNSQLIEHERIHTGEK 605

  Fly   443 PYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHER--RGQSARE-S 504
            |:||..|.|.|..:..|..|:.:||||||:.|:.|||.|.|    .:|.:||:|  .|:...| :
Human   606 PFECSECGKAFGLSKCLIRHQRLHTGEKPYKCNECGKSFNQ----NSHLIIHQRIHTGEKPYECN 666

  Fly   505 VAGLV-SYDTANIV 517
            ..|.| ||.::.:|
Human   667 ECGKVFSYSSSLMV 680

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	6/37 (16%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	30/60 (50%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	13/22 (59%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZKSCAN7	NP_001275519.1	SCAN	51..161	CDD:128708	6/43 (14%)
		SCAN	51..138	CDD:280241	4/20 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	157..215		9/57 (16%)
		KRAB_A-box	231..270	CDD:143639	6/38 (16%)
		COG5048	380..738	CDD:227381	94/336 (28%)
		zf-C2H2	383..405	CDD:278523	4/31 (13%)
		C2H2 Zn finger	385..405	CDD:275368	3/29 (10%)
		zf-H2C2_2	401..422	CDD:290200	4/26 (15%)
		C2H2 Zn finger	413..433	CDD:275368	4/21 (19%)
		zf-H2C2_2	426..450	CDD:290200	3/23 (13%)
		C2H2 Zn finger	441..461	CDD:275368	1/19 (5%)
		zf-H2C2_2	453..478	CDD:290200	2/24 (8%)
		C2H2 Zn finger	469..489	CDD:275368	3/28 (11%)
		zf-H2C2_2	482..506	CDD:290200	7/36 (19%)
		C2H2 Zn finger	497..517	CDD:275368	6/27 (22%)
		zf-H2C2_2	509..532	CDD:290200	8/24 (33%)
		C2H2 Zn finger	525..545	CDD:275368	6/19 (32%)
		zf-H2C2_2	537..562	CDD:290200	11/24 (46%)
		C2H2 Zn finger	553..573	CDD:275368	7/19 (37%)
		zf-H2C2_2	566..590	CDD:290200	14/23 (61%)
		C2H2 Zn finger	581..601	CDD:275368	8/19 (42%)
		zf-H2C2_2	594..616	CDD:290200	11/21 (52%)
		C2H2 Zn finger	609..629	CDD:275368	6/19 (32%)
		zf-H2C2_2	622..646	CDD:290200	13/23 (57%)
		C2H2 Zn finger	637..657	CDD:275368	10/23 (43%)
		zf-H2C2_2	649..674	CDD:290200	8/24 (33%)
		C2H2 Zn finger	665..685	CDD:275368	5/16 (31%)
		zf-H2C2_2	677..701	CDD:290200	1/4 (25%)
		C2H2 Zn finger	693..713	CDD:275368
		zf-H2C2_2	706..730	CDD:290200
		C2H2 Zn finger	721..741	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	735..754
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910