DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and zgc:110249

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	XP_021326434.1	Gene:	zgc:110249 / 553601	ZFINID:	ZDB-GENE-050522-331	Length:	308	Species:	Danio rerio

Alignment Length:	313	Identity:	95/313 - (30%)
Similarity:	133/313 - (42%)	Gaps:	53/313 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   213 DHEMADQALSELSAEIEYLDQVEHDQL----------TESA--HEDDAEVDLNSTEEEFVPSKSV 265
            |.:..:|  ::||.|.|   :.|.|:|          ||.|  ..|...:..:...:.....||:
Zfish    11 DEDTEEQ--TDLSEESE---ESEDDELLKAEKTPHLQTEDALMQRDKKCLTCSQCGKSLANKKSL 70

  Fly   266 --RASIHAR----NATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRR-GNSDSAGSKMSI 323
              ...||..    ..|:...:.|.|.:.|..:.:.:..       ||..... |.|....|  |:
Zfish    71 SQHMMIHTGEKPFTCTQCGTSFRHSLSLTKHMMIHTGE-------NPFSCTHCGKSFRLSS--SL 126

  Fly   324 KSEKDISIGEVLARKH------------SGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLT 376
            |....|..||   |||            |.:|     :.|....||..|.|..||..:.:||.|.
Zfish   127 KEHMMIHTGE---RKHKCDQCSRAFFRASTLK-----RHLKTHTKEKPYSCSECGKRFTTQSNLK 183

  Fly   377 EHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNE 441
            :|.|:|:|||.:.|..|...|.:.:.|..|...|||.:|||||||...||.|..:..|.|.||.|
Zfish   184 QHQKIHTGVKEYMCFDCEKTFIKPEHLKLHQRIHTGEKPYKCSYCDKRFAHLEYQKLHERTHTGE 248

  Fly   442 RPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            :||:|..|.|.|........|:.|||.|||:.||.|.:.|..:.:|:.|..:|
Zfish   249 KPYKCSHCDKRFRSLAHRNRHQKIHTREKPYSCDQCLERFTHSVQLKKHLKVH 301

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	8/19 (42%)
		zf-H2C2_2	375..399	CDD:290200	10/23 (43%)
		COG5048	386..>447	CDD:227381	26/60 (43%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	5/19 (26%)
		zf-H2C2_2	459..481	CDD:290200	10/21 (48%)
		C2H2 Zn finger	474..494	CDD:275368	6/19 (32%)
zgc:110249	XP_021326434.1	C2H2 Zn finger	57..77	CDD:275368	2/19 (11%)
		C2H2 Zn finger	85..105	CDD:275368	4/19 (21%)
		C2H2 Zn finger	113..133	CDD:275368	5/21 (24%)
		COG5048	<138..300	CDD:227381	62/166 (37%)
		C2H2 Zn finger	141..161	CDD:275368	3/24 (13%)
		C2H2 Zn finger	169..189	CDD:275368	8/19 (42%)
		C2H2 Zn finger	197..217	CDD:275368	5/19 (26%)
		C2H2 Zn finger	225..245	CDD:275368	9/19 (47%)
		C2H2 Zn finger	253..273	CDD:275368	5/19 (26%)
		C2H2 Zn finger	281..301	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170581056
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930