DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4936 and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	365	Identity:	107/365 - (29%)
Similarity:	152/365 - (41%)	Gaps:	78/365 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   150 ADDAAETQGGVFHDEIEDGILVELEKDRIVHVKNEQVE-EDGIIEEVYDVYETYEGDLIPDQGYD 213
            |.||...|.|   .:||.|   ||.     |...|..| |||.::                 |.|
Human   349 ASDAVPGQEG---SDIEAG---ELN-----HQNGEPTEVEDGTVD-----------------GAD 385

  Fly   214 HEMAD-----QALSELSAEI--------EYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSV 265
            .:..|     |.:.:|...:        |:.::::.:.|   ..:|..||::|..    :..||.
Human   386 RDEKDFRNPGQEVRKLDLPVLFPNRLGFEFKNEIKKENL---KWDDSEEVEINKA----LQRKSR 443

  Fly   266 RASIHARNATKRRVNPRRSATSTASVAVESS-TSKTTDRGNPLKVRRGNSDS---AGSKMSIKS- 325
            ....|                |.....:||. ||:...|.:|     |.|:.   :..|||.:|
Human   444 GVYWH----------------SELQKGLESEPTSRRQCRNSP-----GESEEKTPSQEKMSHQSF 487

  Fly   326 -EKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHE 389
             .:|.:...:|..|:........||..|  |.|....|..||..:...|.|..|.::|:|.|||:
Human   488 CARDKACTHILCGKNCSQSVHSPHKPAL--KLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHK 550

  Fly   390 CEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFT 454
            |..||..|::...|..|:.||||.|||:|..|..:|...|:...|.|.||.|:||:|.||.|.|.
Human   551 CSECGKGFSERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFN 615

  Fly   455 YTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            .::....|:.|||||.|:.|.||||.|..:.....||..|
Human   616 NSSQFSAHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTH 655

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	27/60 (45%)
		C2H2 Zn finger	390..410	CDD:275368	6/19 (32%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395		19/73 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		8/35 (23%)
		COG5048	<455..668	CDD:227381	76/208 (37%)
		zf-C2H2	522..543	CDD:278523	6/20 (30%)
		C2H2 Zn finger	523..543	CDD:275368	6/19 (32%)
		zf-H2C2_2	535..559	CDD:290200	10/23 (43%)
		C2H2 Zn finger	551..571	CDD:275368	6/19 (32%)
		zf-H2C2_2	563..588	CDD:290200	12/24 (50%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
		zf-H2C2_2	591..616	CDD:290200	12/24 (50%)
		C2H2 Zn finger	607..627	CDD:275368	6/19 (32%)
		zf-H2C2_2	623..644	CDD:290200	13/20 (65%)
		C2H2 Zn finger	635..655	CDD:275368	8/19 (42%)
		zf-H2C2_2	647..671	CDD:290200	3/9 (33%)
		zf-C2H2	661..683	CDD:278523
		C2H2 Zn finger	663..683	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910