DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF107

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	620	Identity:	139/620 - (22%)
Similarity:	219/620 - (35%)	Gaps:	210/620 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CLQQPKEP--------------MASIFNDD----------------------------SEKDLTH 48
            ||:|.|||              |:..|..|                            ..|...|
Human    99 CLEQKKEPWNIKRHEMVAKPPVMSFHFAQDLWPEQNIKDSFQKVTLRRYGKCEYENLQLRKGCKH 163

  Fly    49 MIRECGG--------------VPIKQFDHYPDKICEKCFKVL---------------KMAFKFRE 84
             :.||.|              .|.|.|.      |.|..||.               ...||.:|
Human   164 -VDECTGHKGGHNTVNQCLTATPSKIFQ------CNKYVKVFDKFSNSNRYKRRHTGNKHFKCKE 221

  Fly    85 TCQRSYGHLRQFVGPVEVEQRPPEKKGSE---------TATKLEPDVDPDEAEQEPEHDEEDEDV 140
             |.:|:..|.|......:..|....|..|         |.||.:
Human   222 -CSKSFCVLSQLTQHRRIHTRVNSYKCEECGKAFNWFSTLTKHK--------------------- 264

  Fly   141 DLDESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHV--KNEQVEEDGIIEE------VYD 197
               ..|..|.....|..|..|:..      .:|.:.:|:|.  |..:.||.|...:      ::.
Human   265 ---RIHTGEKPYKCEECGKAFNQS------SQLTRHKIIHTEEKPNKCEECGKAFKQASHLTIHK 320

  Fly   198 VYETYEGDLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPS 262
            :..|.|      :.|.:|...:..|                  :|:|....:: |::.|..:...
Human   321 IIHTGE------KPYKYEECGKVFS------------------QSSHLTTQKI-LHTGENLYKCK 360

  Fly   263 KSVRA-SIHARNATKRRVN----PRRSATSTASVAVESSTSKTTDRGNPLKVRRGNS-------D 315
            :..:| ::.:.....:|::    |.:......:..:.|:.:|..      |:..|..       |
Human   361 ECGKAFNLFSNLTNHKRIHAGEKPYKCKECGRAFNISSNLNKQE------KIHTGGKLNKCEECD 419

  Fly   316 SAGSK-MSIKSEKDISIG------EVLARKHSGIKTKGGHKILLGDKKEFK-------------- 359
            .|.:: :.:.:.|.|.:.      |...:..:...|...|||:...:|.:|
Human   420 KAFNRSLKLTAHKKILMEEKPYKCEECGKVFNQFSTLTRHKIIHTGEKPYKCKECGKAFNQSSNL 484

  Fly   360 ------------YICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTG 412
                        |.|:.||..:...|.|..|.|::||.||::||.||..|.::..|.||...|||
Human   485 TEHKKIHTAEKSYKCEECGKAFNQHSNLINHRKIYSGEKPYKCEECGKAFNRSSTLTRHKKIHTG 549

  Fly   413 NRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVC 477
            .:||||..|..||:..|...:|.:|||.|:||:|:.|.|.|...:||..||.|||||||:.|:.|
Human   550 EKPYKCEECDRAFSQSSNLTEHKKIHTGEKPYKCEECGKAFNRFSTLTKHKRIHTGEKPYKCEEC 614

  Fly   478 GKGFPQAYKLRNHRVIH--------ERRGQSARES 504
            ||.|.|:|:|..|:::|        |..|::.::|
Human   615 GKAFNQSYQLTRHKIVHTKEKLNKCEEFGKAFKQS 649

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	27/139 (19%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	12/23 (52%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	8/19 (42%)
		zf-H2C2_2	459..481	CDD:290200	14/21 (67%)
		C2H2 Zn finger	474..494	CDD:275368	9/19 (47%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630	6/8 (75%)
		C2H2 Zn finger	191..211	CDD:275368	4/19 (21%)
		C2H2 Zn finger	219..239	CDD:275368	5/20 (25%)
		COG5048	243..621	CDD:227381	102/438 (23%)
		C2H2 Zn finger	247..267	CDD:275368	4/43 (9%)
		C2H2 Zn finger	275..295	CDD:275368	5/25 (20%)
		C2H2 Zn finger	303..323	CDD:275368	3/19 (16%)
		C2H2 Zn finger	331..351	CDD:275368	4/38 (11%)
		C2H2 Zn finger	359..379	CDD:275368	2/19 (11%)
		C2H2 Zn finger	387..407	CDD:275368	3/25 (12%)
		C2H2 Zn finger	415..435	CDD:275368	3/19 (16%)
		C2H2 Zn finger	443..463	CDD:275368	5/19 (26%)
		C2H2 Zn finger	471..491	CDD:275368	0/19 (0%)
		C2H2 Zn finger	499..519	CDD:275368	7/19 (37%)
		C2H2 Zn finger	527..547	CDD:275368	8/19 (42%)
		COG5048	551..>863	CDD:227381	43/99 (43%)
		C2H2 Zn finger	555..575	CDD:275368	6/19 (32%)
		C2H2 Zn finger	583..603	CDD:275368	8/19 (42%)
		C2H2 Zn finger	611..631	CDD:275368	9/19 (47%)
		C2H2 Zn finger	639..659	CDD:275368	3/11 (27%)
		C2H2 Zn finger	699..715	CDD:275368
		C2H2 Zn finger	723..743	CDD:275368
		C2H2 Zn finger	751..771	CDD:275368
		C2H2 Zn finger	779..799	CDD:275368
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000