DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and CG14711

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_650094.1	Gene:	CG14711 / 41395	FlyBaseID:	FBgn0037922	Length:	377	Species:	Drosophila melanogaster

Alignment Length:	499	Identity:	141/499 - (28%)
Similarity:	210/499 - (42%)	Gaps:	140/499 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 KWIVCRVCLQQP--KEPMASIFNDDSE--KDLTHMIRECGGVPIKQFDHYPDKICEKCFKVLKMA 79
            ::::||:||.:.  .|.||.:|:|:..  ::|...|.|.|.:.:....:.|..:|..|.:.|..|
  Fly     3 EYMLCRICLTEDINSEAMAPLFDDNDAQCRELVRKIEEVGSIKLVPLQNIPSMLCYSCVERLTSA 67

  Fly    80 FKFRETCQRSYGHLRQFVGPVEVEQRPPEKKGSETATKLEPDVDPDEAEQEPEHDEEDEDVDLD- 143
            .||||.||.|                  |:..:....|         ||.:.|..:|...|..|
  Fly    68 HKFRELCQES------------------ERTFATNVVK---------AEMKSEPTDEVPHVVADN 105

  Fly   144 -ESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYDVYETYEGDLI 207
             |..|..|:|        |.|.:||.|.:|       ::..|.: ||| :.|....|||
  Fly   106 IEYIYESAND--------FIDGVEDDIGME-------NIMEEPL-EDG-VGETSQAYET------ 147

  Fly   208 PDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVR-ASIHA 271
                             |..::.||            |||..|. |||:.::.|.:..| |.:..
  Fly   148 -----------------STVVDDLD------------EDDLLVP-NSTDSDYQPIERCRKAKVRK 182

  Fly   272 RNATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMSIKSEKDISIGEVLA 336
            ...|||.....|.|:|                |:|   |..:.:....:.|.||..::|...::
  Fly   183 TRMTKRGRGRPRGASS----------------GHP---RSFSEERPPVQASFKSSPEVSSTNIM- 227

  Fly   337 RKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQ 401
                                     |::|||:|..::.|..|::.|...||.:||||...||...
  Fly   228 -------------------------CEICGNIYSKRAALNIHMRRHMAEKPFKCEICSKSFAGPS 267

  Fly   402 QLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIH 466
            :|.||:..|||.:|:.|.||..:|||.|:..:|.|.||||||:.|..|.|.|:|:|.||.|.:.|
  Fly   268 ELNRHIRVHTGEKPFLCKYCNRSFADRSSNIRHERTHTNERPFTCSTCGKAFSYSNVLKNHMLTH 332

  Fly   467 TGEKPHVCDVCGKGFPQAYKLRNH--------RVIHERRGQSAR 502
            |||||.:|.||.|.|.:.::|..|        .|||.:..::.|
  Fly   333 TGEKPFLCRVCNKTFSRKHQLDQHLGTMTHQQTVIHHKNERTGR 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	25/76 (33%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	10/23 (43%)
		COG5048	386..>447	CDD:227381	30/60 (50%)
		C2H2 Zn finger	390..410	CDD:275368	9/19 (47%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	418..438	CDD:275368	9/19 (47%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	9/19 (47%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	8/27 (30%)
CG14711	NP_650094.1	zf-AD	6..81	CDD:285071	26/92 (28%)
		C2H2 Zn finger	228..248	CDD:275368	7/19 (37%)
		zf-H2C2_2	240..264	CDD:290200	9/23 (39%)
		COG5048	249..>362	CDD:227381	52/112 (46%)
		C2H2 Zn finger	256..276	CDD:275368	9/19 (47%)
		zf-H2C2_2	268..292	CDD:290200	10/23 (43%)
		C2H2 Zn finger	284..304	CDD:275368	9/19 (47%)
		zf-H2C2_2	299..321	CDD:290200	12/21 (57%)
		C2H2 Zn finger	312..332	CDD:275368	9/19 (47%)
		zf-H2C2_2	325..349	CDD:290200	14/23 (61%)
		C2H2 Zn finger	340..362	CDD:275368	7/21 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3C1GA
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	120	1.000	Inparanoid score	I3338
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.860