DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4936 and ZNF888

DIOPT Version :9

Sequence 1:NP_650862.1 Gene:CG4936 / 42393 FlyBaseID:FBgn0038768 Length:521 Species:Drosophila melanogaster
Sequence 2:XP_016882287.1 Gene:ZNF888 / 388559 HGNCID:38695 Length:830 Species:Homo sapiens


Alignment Length:423 Identity:117/423 - (27%)
Similarity:176/423 - (41%) Gaps:93/423 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly   140 VDLDESHYAEADDAAETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYD-VYETYE 203
            |.||.|.....:.::..:|..  :.|..|.|..|....|.....:::|:|     ::| |::..|
Human   157 VSLDISSKCMMEFSSIGKGNT--EVIHTGTLQRLASHHIGECCFQEIEKD-----IHDFVFQWQE 214

  Fly   204 GDLIPDQGYDHEMADQALSELSAEIEYLDQ-------VEHDQLTESAHEDDAEVDLNSTEEEFVP 261
                 |:...||.....:.||:...:..||       ::: ||..|.|....|:.:      |.|
Human   215 -----DETNGHEAPMTEIKELTGSTDQYDQRHAGNKPIKY-QLGSSFHSHLPELHI------FQP 267

  Fly   262 SKSVRASIHARNATKRRVNPRRSATSTASVAVESSTSKTTDRGNPLKVRRGNSDSAGSKMSI-KS 325
            ...:      .|..::.:|...|.:::..::....|..:.:.||..    .:|.....|..: :.
Human   268 EGKI------GNQLEKSINNASSVSTSQRISCRPKTHISNNYGNNF----FHSSLLTQKQDVHRK 322

  Fly   326 EKDISIGE--------VLARKHSGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVH 382
            ||.....|        .|.:||..|.        ||:|   :|.|||||..:..:..|..|.:.|
Human   323 EKSFQFNESGKSFNCSSLFKKHQIIH--------LGEK---QYKCDVCGKDFNQKRYLAHHRRCH 376

  Fly   383 SGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLS---------TRNK----- 433
            :|.||:.|..||..|.:...||||...|||.:||||:.|...|:|.|         |..|     
Human   377 TGEKPYMCNKCGKVFNKKAYLARHYRRHTGEKPYKCNECGKTFSDKSALLVHKTIHTGEKPYKCN 441

  Fly   434 --------------HHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQA 484
                          |||:||.|:||:|..|.|.|:..:.|:.|:.|||||||:.|.||.|.|...
Human   442 ECGKVFNQQSNLARHHRVHTGEKPYQCKECDKVFSRKSYLERHRRIHTGEKPYKCKVCDKAFRHD 506

  Fly   485 YKLRNHRVIHERR--------GQSARESVAGLV 509
            ..|..|.|||.|.        |::..|:.|.||
Human   507 SHLAQHIVIHTREKPYKCNECGKTFGENSALLV 539

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4936NP_650862.1 zf-AD 22..95 CDD:214871
C2H2 Zn finger 362..382 CDD:275368 7/19 (37%)
zf-H2C2_2 375..399 CDD:290200 10/23 (43%)
COG5048 386..>447 CDD:227381 31/88 (35%)
C2H2 Zn finger 390..410 CDD:275368 8/19 (42%)
zf-H2C2_2 403..426 CDD:290200 12/22 (55%)
C2H2 Zn finger 418..438 CDD:275368 10/47 (21%)
zf-H2C2_2 432..455 CDD:290200 13/41 (32%)
C2H2 Zn finger 446..466 CDD:275368 6/19 (32%)
zf-H2C2_2 459..481 CDD:290200 13/21 (62%)
C2H2 Zn finger 474..494 CDD:275368 8/19 (42%)
ZNF888XP_016882287.1 None
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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