DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and Zkscan7

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001170976.1	Gene:	Zkscan7 / 382118	MGIID:	3040678	Length:	718	Species:	Mus musculus

Alignment Length:	432	Identity:	112/432 - (25%)
Similarity:	182/432 - (42%)	Gaps:	90/432 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    97 VGPVEVEQRPPEKKGSET-------------ATKLEPDVDPDEAEQEPEHDEEDEDVDLDESHYA 148
            :|..|...:....|||.:             ..:...|:..|...|..||..::|...| ||.:.
Mouse   246 IGSSEFSPKQDISKGSHSLDTSSEGLFGVALVERASGDICKDPLAQREEHPSDEEGSGL-ESDFL 309

  Fly   149 EADDAAETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYDVYETYEGDLIPDQGYD 213
            |.:|...|         ||              :||:.::.|:..|:......::|:....:.|.
Mouse   310 EKEDKNST---------ED--------------RNEECKDVGVHPEMPSSPVEHQGEAKRQKSYQ 351

  Fly   214 HEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEEFVPSKSVRASIHARNATKRR 278
            .:...:..|:.|..:.:          :..|..:...:.|...:.|  .:..:..:|.|..|:.:
Mouse   352 CDECGKVFSQSSRFLGH----------QRIHVGERPFECNKCGKTF--QQISQLVVHLRIHTQEK 404

  Fly   279 VNPRRSATSTASVAVESSTSKTTDRGNPL----KVRRGNSDSAGS---KMSIKSEKDISIGEVLA 336
              |.....|          .||....:.|    ::|.|:....|:   :.||:|.:.:    |..
Mouse   405 --PYECCES----------GKTYCHSSHLIQHQRLRNGDKPYKGNECVRASIQSSQLL----VHK 453

  Fly   337 RKHSGIK-TKGG-----------HKILLGDKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHE 389
            |.|:|.| .:.|           |::|...||  .|.|:.||..:.:...|.:|.::|:|.||:|
Mouse   454 RTHTGEKPDESGEAFIWNKSLIQHQVLHISKK--LYECNECGKAFYTNRNLIDHQRIHTGEKPYE 516

  Fly   390 CEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFT 454
            |..||..|::::.|.||.:.|||.:.||||.|..||...|....|.|:||.|:|:||..|.|.|:
Mouse   517 CIECGKSFSRSKCLTRHQSLHTGEKTYKCSECGKAFLQNSQLIDHKRVHTGEKPFECSECGKKFS 581

  Fly   455 YTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHER 496
            ....|..|:.:||||||:.|..|||.|.|    .:|.:||:|
Mouse   582 LGKCLIRHQRLHTGEKPYKCSECGKSFNQ----NSHLIIHQR 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	5/19 (26%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	418..438	CDD:275368	8/19 (42%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
Zkscan7	NP_001170976.1	SCAN	46..156	CDD:128708
		SCAN	46..133	CDD:280241
		COG5048	333..702	CDD:227381	89/321 (28%)
		C2H2 Zn finger	352..372	CDD:275368	2/29 (7%)
		zf-H2C2_2	368..387	CDD:290200	2/28 (7%)
		C2H2 Zn finger	380..400	CDD:275368	4/21 (19%)
		C2H2 Zn finger	408..427	CDD:275368	4/28 (14%)
		C2H2 Zn finger	437..453	CDD:275368	4/19 (21%)
		zf-C2H2	487..509	CDD:278523	6/21 (29%)
		C2H2 Zn finger	489..509	CDD:275368	5/19 (26%)
		zf-H2C2_2	501..526	CDD:290200	11/24 (46%)
		C2H2 Zn finger	517..537	CDD:275368	7/19 (37%)
		zf-H2C2_2	530..554	CDD:290200	13/23 (57%)
		C2H2 Zn finger	545..565	CDD:275368	8/19 (42%)
		zf-H2C2_2	561..581	CDD:290200	10/19 (53%)
		C2H2 Zn finger	573..593	CDD:275368	6/19 (32%)
		zf-H2C2_2	586..610	CDD:290200	13/23 (57%)
		C2H2 Zn finger	601..621	CDD:275368	10/23 (43%)
		zf-H2C2_2	613..638	CDD:290200	4/7 (57%)
		C2H2 Zn finger	629..649	CDD:275368
		zf-H2C2_2	641..664	CDD:290200
		C2H2 Zn finger	657..677	CDD:275368
		zf-H2C2_2	670..694	CDD:290200
		C2H2 Zn finger	685..705	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4340
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.960