DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF568

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_940941.2	Gene:	ZNF568 / 374900	HGNCID:	25392	Length:	644	Species:	Homo sapiens

Alignment Length:	544	Identity:	136/544 - (25%)
Similarity:	207/544 - (38%)	Gaps:	123/544 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 TSTQKWIVCRVCLQQPKEPMASIFNDDSEKDLTH---MIR-ECGGVPIKQFDHYPDKICEKCFKV 75
            ||.|.:..|                |..:|.|.|   ::| |.|.|..||.:.: .|....|...
Human   170 TSRQSFYDC----------------DSLDKGLEHNLDLLRYEKGCVREKQSNEF-GKPFYHCASY 217

  Fly    76 LKMAFKFRETCQRSYGHLRQFV--GPVEVEQRPPEKKGSETATKLEPDVDPDEAEQEPEHDEEDE 138
            :...||..: |.:.:.|....:  ..:...::|.|.|                 |.......::.
Human   218 VVTPFKCNQ-CGQDFSHKFDLIRHERIHAGEKPYECK-----------------ECGKAFSRKEN 264

  Fly   139 DVDLDESHYAEADDAAETQGGVF--------HDEIEDGILVELEKD--RIVHVKNEQVEEDGIIE 193
            .:...:.|..|........|..|        |..|..|......||  :....|:..:|.:.|
Human   265 LITHQKIHTGEKPYKCNECGKAFIQMSNLIRHHRIHTGEKPYACKDCWKAFSQKSNLIEHERI-- 327

  Fly   194 EVYDVYETYEGDLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNSTEEE 258
                    :.|    ::.|:.:...::.|:..      :.:||:::    |..:.....|.....
Human   328 --------HTG----EKPYECKECGKSFSQKQ------NLIEHEKI----HTGEKPYACNECGRA 370

  Fly   259 FVPSKSVRASIHARNATKR---RVNPRRSATSTASVAVESSTSKTTDRGNPLKVRR-GNSDSAGS 319
            |....||  ::|.|:.|..   :.|....|.|..||.:....|.|.::  |..... |.:.|..|
Human   371 FSRMSSV--TLHMRSHTGEKPYKCNKCGKAFSQCSVFIIHMRSHTGEK--PYVCSECGKAFSQSS 431

  Fly   320 KMSI-----KSEKDI---SIGEVLARKHSGIKTKGGHKILLGDKK-------------------- 356
            .:::     .:||..   ..|:..:||.:.|..:   ||..|:|.
Human   432 SLTVHMRNHTAEKPYECKECGKAFSRKENLITHQ---KIHTGEKPYECSECGKAFIQMSNLIRHQ 493

  Fly   357 -----EFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPY 416
                 |..|.|.|||..:..:|.||||.|:|:|.||:.|..||..|:|.|.|..|...|||.:|:
Human   494 RIHTGEKPYACTVCGKAFSQKSNLTEHEKIHTGEKPYHCNQCGKAFSQRQNLLEHEKIHTGEKPF 558

  Fly   417 KCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGF 481
            ||:.|..||:.:|:...|.|.||.|:||||:.|.|.|:..:.|..|...||||||..|:.|||.|
Human   559 KCNECGKAFSRISSLTLHVRSHTGEKPYECNKCGKAFSQCSLLIIHMRSHTGEKPFECNECGKAF 623

  Fly   482 PQAYKLRNHRVIHERRGQSARESV 505
            .|...|.    ||:|.....|..|
Human   624 SQRASLS----IHKRGHTGERHQV 643

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	17/76 (22%)
		C2H2 Zn finger	362..382	CDD:275368	10/19 (53%)
		zf-H2C2_2	375..399	CDD:290200	13/23 (57%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	8/19 (42%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZNF568	NP_940941.2	KRAB	48..102	CDD:214630
		KRAB	48..87	CDD:279668
		C2H2 Zn finger	224..244	CDD:275368	2/20 (10%)
		zf-H2C2_2	236..261	CDD:290200	4/41 (10%)
		COG5048	248..634	CDD:227381	113/437 (26%)
		C2H2 Zn finger	252..272	CDD:275368	2/36 (6%)
		zf-H2C2_2	264..289	CDD:290200	4/24 (17%)
		C2H2 Zn finger	280..300	CDD:275368	3/19 (16%)
		zf-H2C2_2	292..317	CDD:290200	5/24 (21%)
		C2H2 Zn finger	308..328	CDD:275368	5/29 (17%)
		zf-H2C2_2	320..345	CDD:290200	4/38 (11%)
		C2H2 Zn finger	336..356	CDD:275368	3/29 (10%)
		zf-H2C2_2	348..373	CDD:290200	5/28 (18%)
		C2H2 Zn finger	364..384	CDD:275368	6/21 (29%)
		zf-H2C2_2	380..401	CDD:290200	5/20 (25%)
		C2H2 Zn finger	392..412	CDD:275368	5/19 (26%)
		zf-H2C2_2	408..429	CDD:290200	4/22 (18%)
		C2H2 Zn finger	420..440	CDD:275368	3/19 (16%)
		zf-H2C2_2	432..457	CDD:290200	3/24 (13%)
		C2H2 Zn finger	448..468	CDD:275368	5/22 (23%)
		zf-H2C2_2	460..485	CDD:290200	5/27 (19%)
		C2H2 Zn finger	476..496	CDD:275368	0/19 (0%)
		zf-H2C2_2	488..513	CDD:290200	6/24 (25%)
		C2H2 Zn finger	504..524	CDD:275368	10/19 (53%)
		zf-H2C2_2	516..541	CDD:290200	13/24 (54%)
		C2H2 Zn finger	532..552	CDD:275368	8/19 (42%)
		zf-H2C2_2	544..569	CDD:290200	11/24 (46%)
		C2H2 Zn finger	560..580	CDD:275368	7/19 (37%)
		zf-H2C2_2	572..597	CDD:290200	12/24 (50%)
		C2H2 Zn finger	588..608	CDD:275368	6/19 (32%)
		zf-H2C2_2	601..625	CDD:290200	13/23 (57%)
		C2H2 Zn finger	616..636	CDD:275368	10/23 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000