DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4936 and ZNF850

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001180481.1	Gene:	ZNF850 / 342892	HGNCID:	27994	Length:	1090	Species:	Homo sapiens

Alignment Length:	185	Identity:	72/185 - (38%)
Similarity:	99/185 - (53%)	Gaps:	14/185 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   320 KMSIKSEKDISIGEVLARKH---------SGIKTKGGHKILLGDKKEFKYICDVCGNMYPSQSRL 375
            :..:...:.|..||...|.|         ||: || .|.|..|:|   .|.|..||..:..::.|
Human   909 RSKLTQHQRIHTGEKPYRCHECGKAFVRFSGL-TK-HHSIHTGEK---PYECKTCGKSFRQRTHL 968

  Fly   376 TEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTN 440
            |.|.::|:|.:|:||:.||..|....:|.||..||||.:||.|..|..||...|..::|.||||.
Human   969 TLHQRIHTGDRPYECKECGKSFTCGSELIRHQRTHTGEKPYDCKECGKAFRCPSQLSQHKRIHTG 1033

  Fly   441 ERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHE 495
            |:.|:|..|.|.|.|.:.|..|:.:||||||:.|..|||.|.|..:|..|:.||:
Human  1034 EKTYQCPECGKAFFYASGLSRHQSVHTGEKPYECKTCGKAFKQLTQLTRHQRIHD 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	27/60 (45%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	12/22 (55%)
		C2H2 Zn finger	418..438	CDD:275368	7/19 (37%)
		zf-H2C2_2	432..455	CDD:290200	11/22 (50%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
ZNF850	NP_001180481.1	KRAB	7..67	CDD:214630
		KRAB	7..46	CDD:279668
		C2H2 Zn finger	199..219	CDD:275368
		C2H2 Zn finger	227..244	CDD:275368
		COG5048	243..659	CDD:227381
		C2H2 Zn finger	255..275	CDD:275368
		C2H2 Zn finger	283..303	CDD:275368
		zf-H2C2_2	296..319	CDD:290200
		C2H2 Zn finger	311..331	CDD:275368
		zf-H2C2_2	324..348	CDD:290200
		C2H2 Zn finger	339..359	CDD:275368
		zf-H2C2_2	351..375	CDD:290200
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	379..403	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
		C2H2 Zn finger	423..443	CDD:275368
		zf-H2C2_2	436..460	CDD:290200
		C2H2 Zn finger	451..471	CDD:275368
		zf-H2C2_2	463..487	CDD:290200
		C2H2 Zn finger	479..499	CDD:275368
		zf-H2C2_2	493..516	CDD:290200
		C2H2 Zn finger	507..527	CDD:275368
		zf-H2C2_2	519..543	CDD:290200
		COG5048	531..947	CDD:227381	10/39 (26%)
		C2H2 Zn finger	535..555	CDD:275368
		C2H2 Zn finger	563..583	CDD:275368
		zf-H2C2_2	575..599	CDD:290200
		C2H2 Zn finger	591..611	CDD:275368
		C2H2 Zn finger	619..639	CDD:275368
		zf-H2C2_2	632..656	CDD:290200
		C2H2 Zn finger	647..667	CDD:275368
		zf-H2C2_2	660..684	CDD:290200
		C2H2 Zn finger	675..695	CDD:275368
		zf-H2C2_2	687..711	CDD:290200
		C2H2 Zn finger	703..723	CDD:275368
		C2H2 Zn finger	732..751	CDD:275368
		C2H2 Zn finger	759..779	CDD:275368
		C2H2 Zn finger	787..807	CDD:275368
		C2H2 Zn finger	815..835	CDD:275368
		C2H2 Zn finger	843..863	CDD:275368
		zf-H2C2_2	856..879	CDD:290200
		C2H2 Zn finger	871..891	CDD:275368
		C2H2 Zn finger	899..919	CDD:275368	0/9 (0%)
		zf-H2C2_2	912..936	CDD:290200	5/23 (22%)
		C2H2 Zn finger	927..947	CDD:275368	6/21 (29%)
		C2H2 Zn finger	955..975	CDD:275368	6/19 (32%)
		zf-H2C2_2	967..992	CDD:290200	11/24 (46%)
		C2H2 Zn finger	983..1003	CDD:275368	7/19 (37%)
		zf-H2C2_2	995..1020	CDD:290200	13/24 (54%)
		C2H2 Zn finger	1011..1031	CDD:275368	7/19 (37%)
		zf-H2C2_2	1024..1046	CDD:290200	10/21 (48%)
		C2H2 Zn finger	1039..1059	CDD:275368	7/19 (37%)
		zf-H2C2_2	1052..1076	CDD:290200	13/23 (57%)
		C2H2 Zn finger	1067..1087	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910