DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and ZNF852

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_001274278.1	Gene:	ZNF852 / 285346	HGNCID:	27713	Length:	530	Species:	Homo sapiens

Alignment Length:	529	Identity:	127/529 - (24%)
Similarity:	192/529 - (36%)	Gaps:	145/529 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 PMASIFNDDSEKDLTHMIRECGGVPIKQFDHYP-----DKICEKCFKVLKMAFKFRETCQRSYGH 92
            |...||......:.|     .||:    |...|     ..:||..||
Human    59 PKQEIFKGSESSNST-----SGGL----FGVVPGGTETGDVCEDTFK------------------ 96

  Fly    93 LRQFVGPVEVEQRPPEKKGSETATKLEPD----VDPDEAEQEPEHDEEDEDVDLDESHYAEADDA 153
                    |:|.:|..::||    :||.|    :|.|:.:...:..||.::|   |.|...:...
Human    97 --------ELEGQPSNEEGS----RLESDFLEIIDEDKKKSTKDRYEEYKEV---EEHPPLSSSP 146

  Fly   154 AETQGG----------------------VFHDEIEDGILVELEK---------------DRIVHV 181
            .|.:|.                      :.|..|..|     ||               ..|||:
Human   147 VEHEGVLKGQKSYRCDECGKAFYWSSHLIGHRRIHTG-----EKPYECNECGKTFRQTSQLIVHL 206

  Fly   182 KNEQVEEDGIIEEVYDVYETYEGDLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHED 246
            :....|:.         ||..|    ..:.|.|.      |.|         ::|.:|    |..
Human   207 RTHTGEKP---------YECSE----CGKAYRHS------SHL---------IQHQRL----HNG 239

  Fly   247 DAEVDLNSTEEEFVPSKSVRASIHARNATKRRVNPRRSATSTAS----------VAVESSTSKTT 301
            :.....|...:.|  ::|.:...|.|..|..:....:...:..|          :.......|..
Human   240 EKPYKCNECAKAF--NQSSKLFDHQRTHTGEKPYECKECGAAFSRSKNLVRHQFLHTGKKPYKCN 302

  Fly   302 DRGNPLKVRRGNSDSAGSKMSIKSEKDISIGEVLARKHSGIKTKGGHKILLGDKKEFKYICDVCG 366
            :.|......|...|...:....|..|....|:..:|....|:.:..|   .|:|   .|.|..||
Human   303 ECGRAFCSNRNLIDHQRTHTGEKPYKCNECGKAFSRSKCLIRHQSLH---TGEK---PYKCSECG 361

  Fly   367 NMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTR 431
            ..:...|:|.||.::|:|.||.:|..||..|..::.|.||...||..:||||:.|..:|...|..
Human   362 KAFNQISQLVEHERIHTGEKPFKCSECGKAFGLSKCLIRHQRLHTSEKPYKCNECGKSFNQNSYL 426

  Fly   432 NKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIHER 496
            ..|.||||.|:||||:.|.|.|:|.::|..|:..||||||:.|:.|||.|..:.:|..|:.:|
Human   427 IIHQRIHTGEKPYECNECGKVFSYNSSLMVHQRTHTGEKPYKCNSCGKAFSDSSQLTVHQRVH-- 489

  Fly   497 RGQSARESV 505
            .|:...|.:
Human   490 TGEKPYECI 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871	12/66 (18%)
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	11/23 (48%)
		COG5048	386..>447	CDD:227381	27/60 (45%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	10/22 (45%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	13/22 (59%)
		C2H2 Zn finger	446..466	CDD:275368	7/19 (37%)
		zf-H2C2_2	459..481	CDD:290200	12/21 (57%)
		C2H2 Zn finger	474..494	CDD:275368	7/19 (37%)
ZNF852	NP_001274278.1	KRAB_A-box	8..47	CDD:143639
		COG5048	156..514	CDD:227381	98/390 (25%)
		C2H2 Zn finger	161..181	CDD:275368	1/19 (5%)
		zf-H2C2_2	177..198	CDD:290200	5/25 (20%)
		C2H2 Zn finger	189..209	CDD:275368	3/19 (16%)
		zf-H2C2_2	202..226	CDD:290200	8/36 (22%)
		C2H2 Zn finger	217..237	CDD:275368	7/42 (17%)
		C2H2 Zn finger	245..265	CDD:275368	5/21 (24%)
		zf-H2C2_2	261..282	CDD:290200	3/20 (15%)
		C2H2 Zn finger	273..293	CDD:275368	1/19 (5%)
		zf-C2H2	299..321	CDD:278523	4/21 (19%)
		C2H2 Zn finger	301..321	CDD:275368	3/19 (16%)
		zf-H2C2_2	313..338	CDD:290200	4/24 (17%)
		C2H2 Zn finger	329..349	CDD:275368	3/19 (16%)
		zf-H2C2_2	342..366	CDD:290200	8/29 (28%)
		C2H2 Zn finger	357..377	CDD:275368	7/19 (37%)
		zf-H2C2_2	370..392	CDD:290200	10/21 (48%)
		C2H2 Zn finger	385..405	CDD:275368	7/19 (37%)
		zf-H2C2_2	398..422	CDD:290200	11/23 (48%)
		C2H2 Zn finger	413..433	CDD:275368	6/19 (32%)
		zf-H2C2_2	425..450	CDD:290200	13/24 (54%)
		C2H2 Zn finger	441..461	CDD:275368	7/19 (37%)
		zf-H2C2_2	453..477	CDD:290200	12/23 (52%)
		C2H2 Zn finger	469..489	CDD:275368	7/19 (37%)
		zf-H2C2_2	482..506	CDD:290200	5/19 (26%)
		C2H2 Zn finger	497..517	CDD:275368	0/2 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000