DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and Zscan20

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_808426.2	Gene:	Zscan20 / 269585	MGIID:	2679268	Length:	1030	Species:	Mus musculus

Alignment Length:	424	Identity:	128/424 - (30%)
Similarity:	179/424 - (42%)	Gaps:	94/424 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 EADDAAETQGGVFHDEIEDGILVEL------EKDRIVHVKNEQVEEDGIIEEVYDVYETYEGDLI 207
            |||| .|..|     |:||...|.|      ..|....:|.|  |||.|.|:  ||.....|.|.
Mouse   589 EADD-QEAWG-----EMEDEDAVRLLTPDSQPADAGFELKRE--EEDQISEQ--DVLGDLPGALS 643

  Fly   208 P----------DQGYDHEMADQ-----ALSELSAEIEYLDQVEHD--QLTESAHEDDAEVDLNST 255
            .          |.|.||...::     ...|.|:|.:....::|.  .|||..:..|......|.
Mouse   644 RYTTKAVCQPCDWGEDHVNGNEGEWRNTWEECSSEEDLEKLIDHQGLYLTEKPYGCDTRAKSFSR 708

  Fly   256 EEEFV----------PSKSVRA----SIHARNATKRRVN----PRRSATSTASVAVESS--TSKT 300
            :..|.          |.|.:.:    |..|..:|.:|::    |.|......|....|:  |.:.
Mouse   709 KVHFFAPQRTHSSEKPYKCLGSGKSFSDRANLSTHQRIHIGEKPYRCLECGKSFNDPSNLITHQR 773

  Fly   301 TDRG-----------------NPLKVRRGNSDSAGSKMSIKSEKDISIGEVLA-----RKHSGIK 343
            |..|                 |.||.:|.:   .|...:.:.|...:.|:.|:     |::|
Mouse   774 THTGEKPYKCGLCWKSFNQSSNLLKHQRVH---LGGPPNQRDEPGENFGQSLSYSAHWRRNS--- 832

  Fly   344 TKGGHK----ILLG---------DKKEFKYICDVCGNMYPSQSRLTEHIKVHSGVKPHECEICGH 395
            |:.|.|    |.:|         :..|..|.|..||..:...|.||.|.::|||.||:||.:||.
Mouse   833 TQEGPKEPQNISMGADSPGACHPNSGEKLYSCPECGRCFSKSSALTSHQRIHSGEKPYECAVCGK 897

  Fly   396 CFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPYECDVCHKTFTYTNTLK 460
            .|:::..||.|..||||.:|:||:.|...|::.|....|.|:||.|:||||..|.|.|...:.|.
Mouse   898 SFSKSSSLANHRRTHTGEKPHKCADCGKCFSERSKLITHQRVHTGEKPYECPECGKFFRDRSNLI 962

  Fly   461 FHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            .|:.|||||||:.|..|||.|.|:..|..|:.||
Mouse   963 THQRIHTGEKPYKCRECGKCFNQSSSLIIHQRIH 996

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	7/19 (37%)
		zf-H2C2_2	375..399	CDD:290200	13/23 (57%)
		COG5048	386..>447	CDD:227381	28/60 (47%)
		C2H2 Zn finger	390..410	CDD:275368	7/19 (37%)
		zf-H2C2_2	403..426	CDD:290200	11/22 (50%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	6/19 (32%)
		zf-H2C2_2	459..481	CDD:290200	13/21 (62%)
		C2H2 Zn finger	474..494	CDD:275368	8/19 (42%)
Zscan20	NP_808426.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..42
		SCAN	41..126	CDD:366881
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	178..201
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..285
		Myb_DNA-bind_4	315..400	CDD:372747
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	411..441
		Myb_DNA-bind_4	476..561	CDD:372747
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	578..600		7/16 (44%)
		COG5048	686..1020	CDD:227381	98/317 (31%)
		C2H2 Zn finger	727..747	CDD:275368	4/19 (21%)
		C2H2 Zn finger	755..775	CDD:275368	3/19 (16%)
		C2H2 Zn finger	783..803	CDD:275368	4/19 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	801..820		3/21 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	828..850		7/24 (29%)
		C2H2 Zn finger	864..884	CDD:275368	7/19 (37%)
		C2H2 Zn finger	892..912	CDD:275368	7/19 (37%)
		C2H2 Zn finger	920..940	CDD:275368	6/19 (32%)
		C2H2 Zn finger	948..968	CDD:275368	6/19 (32%)
		C2H2 Zn finger	976..996	CDD:275368	8/19 (42%)
		C2H2 Zn finger	1004..1024	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	151	1.000	Inparanoid score	I4340
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.050