DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4936 and ZBTB20

DIOPT Version :9

Sequence 1:NP_650862.1 Gene:CG4936 / 42393 FlyBaseID:FBgn0038768 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_001157814.1 Gene:ZBTB20 / 26137 HGNCID:13503 Length:741 Species:Homo sapiens


Alignment Length:469 Identity:108/469 - (23%)
Similarity:182/469 - (38%) Gaps:110/469 - (23%)


- Green bases have known domain annotations that are detailed below.


  Fly    93 LRQFVGPVEVEQRPPEKKGSETATKLEPDVD--PDEAEQEPEHDEEDE-DVDLDESHYAEADDAA 154
            ::..||.:.::|            ::|.|.|  ..:..|..|.:|.:| ..|.|::...|    :
Human   320 IQTLVGNIHIKQ------------EMEDDYDYYGQQRVQILERNESEECTEDTDQAEGTE----S 368

  Fly   155 ETQGGVFHDEIEDGILVELEKDRIVHVKNEQVEEDGIIEEVYDVYETYEGDLIPDQGYDHEMADQ 219
            |.:|..|...:...|..|.:.                :|:.:......:....|.|   .|.|.:
Human   369 EPKGESFDSGVSSSIGTEPDS----------------VEQQFGPGAARDSQAEPTQ---PEQAAE 414

  Fly   220 ALSELSAEIEYLDQVEHDQLTESAHEDDAEVDL--------NSTEEEFVPSKSVRASIHARNATK 276
            |.:|...:...|      :...|:.|...||::        ||:::..:...||..|| .:....
Human   415 APAEGGPQTNQL------ETGASSPERSNEVEMDSTVITVSNSSDKSVLQQPSVNTSI-GQPLPS 472

  Fly   277 RRVNPRRSATSTAS----VAVESSTSKTTDRGNPLKVRRGNSDSAGS--KMSIKSEKDISIGEVL 335
            .::..|::.|.|::    :.:.|:|......||........:..|||  |..:     .|:.:.|
Human   473 TQLYLRQTETLTSNLRMPLTLTSNTQVIGTAGNTYLPALFTTQPAGSGPKPFL-----FSLPQPL 532

  Fly   336 ARKHS--------GIKT-------------KGGHKILLGDKKEFKYICDVCGNMYPSQSRLTEHI 379
            |.:.:        |:.|             ..||....|..::..|.|.:|...:.::....:|:
Human   533 AGQQTQFVTVSQPGLSTFTAQLPAPQPLASSAGHSTASGQGEKKPYECTLCNKTFTAKQNYVKHM 597

  Fly   380 KVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLSTRNKHHRIHTNERPY 444
            .||:|.|||:|.||...|:....|.:||.||||.|.|:||.|...|...|:.|.|.|:|..|:.|
Human   598 FVHTGEKPHQCSICWRSFSLKDYLIKHMVTHTGVRAYQCSICNKRFTQKSSLNVHMRLHRGEKSY 662

  Fly   445 ECDVCHKTFTYTNTLKFHKMIHT--------GEKP-----------------HVCDVCGKGFPQA 484
            ||.:|.|.|::...|:.|..:|:        |..|                 :||.||...|.|.
Human   663 ECYICKKKFSHKTLLERHVALHSASNGTPPAGTPPGARAGPPGVVACTEGTTYVCSVCPAKFDQI 727

  Fly   485 YKLRNHRVIHERRG 498
            .:..:|..:|...|
Human   728 EQFNDHMRMHVSDG 741

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4936NP_650862.1 zf-AD 22..95 CDD:214871 0/1 (0%)
C2H2 Zn finger 362..382 CDD:275368 3/19 (16%)
zf-H2C2_2 375..399 CDD:290200 11/23 (48%)
COG5048 386..>447 CDD:227381 28/60 (47%)
C2H2 Zn finger 390..410 CDD:275368 7/19 (37%)
zf-H2C2_2 403..426 CDD:290200 12/22 (55%)
C2H2 Zn finger 418..438 CDD:275368 8/19 (42%)
zf-H2C2_2 432..455 CDD:290200 11/22 (50%)
C2H2 Zn finger 446..466 CDD:275368 6/19 (32%)
zf-H2C2_2 459..481 CDD:290200 9/46 (20%)
C2H2 Zn finger 474..494 CDD:275368 6/19 (32%)
ZBTB20NP_001157814.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..32
BTB_POZ_ZBTB20_DPZF 79..195 CDD:349517
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 203..235
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 350..440 21/118 (18%)
PHA03169 <352..>442 CDD:223003 22/118 (19%)
Med15 <378..>571 CDD:312941 38/223 (17%)
zf-C2H2 578..600 CDD:395048 4/21 (19%)
C2H2 Zn finger 580..600 CDD:275368 3/19 (16%)
SUF4-like 608..>657 CDD:411020 21/48 (44%)
C2H2 Zn finger 608..629 CDD:411020 8/20 (40%)
C2H2 Zn finger 608..628 CDD:275368 7/19 (37%)
zf-C2H2 634..656 CDD:395048 9/21 (43%)
C2H2 Zn finger 636..656 CDD:411020 8/19 (42%)
C2H2 Zn finger 636..656 CDD:275368 8/19 (42%)
zf-H2C2_2 648..673 CDD:404364 11/24 (46%)
C2H2 Zn finger 664..684 CDD:275368 6/19 (32%)
C2H2 Zn finger 717..737 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4637
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.950

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