DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4936 and Zbtb6

DIOPT Version :9

Sequence 1:	NP_650862.1	Gene:	CG4936 / 42393	FlyBaseID:	FBgn0038768	Length:	521	Species:	Drosophila melanogaster
Sequence 2:	NP_666365.1	Gene:	Zbtb6 / 241322	MGIID:	2442998	Length:	423	Species:	Mus musculus

Alignment Length:	338	Identity:	77/338 - (22%)
Similarity:	134/338 - (39%)	Gaps:	61/338 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   191 IIEEVYDVYETY-EGDLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEVDLNS 254
            |:|:..:....| |.||........::...:.:::..|.|..|  :..::.|.:.:....:|.:.
Mouse   115 IVEKCTEALSKYLEIDLSMKNNQHTDLCQSSDTDVKNEEENSD--KDCEIIEISEDSPVNLDFHV 177

  Fly   255 TEEEFVPSKSVRASIHARNATKRRV-NPRRSA-------TSTASVAVESSTSKTTDRG---NPLK 308
            .|||   |.:::::.....:.:.|: :|..||       .....:.|||.::...:.|   .|.
Mouse   178 KEEE---SNALQSAAETLTSERMRMQSPELSAVDGGFKENEICILHVESISTDDVENGQFSQPC- 238

  Fly   309 VRRGNSDSAG------SKMSIKSEKDISIGEVLARKHSGI---KTKGGHKILLGDKKEFKYICDV 364
                .|..||      ....|.|..:..:.||....:.|:   .:.|.|    |...|.:
Mouse   239 ----TSSKAGIYFPETQHSLINSTVENRVTEVPGNTNQGLFSENSDGSH----GTVNEIQ----- 290

  Fly   365 CGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLS 429
                     .|.|:..:.     |:|..|...|...:...||:..|   :.:.|..|...|....
Mouse   291 ---------NLDENFSLR-----HQCPRCPRGFLHVENYLRHLKMH---KLFLCLQCGKTFTQKK 338

  Fly   430 TRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRV-I 493
            ..|:|.|.|...||::|.||.||||..:||:.|..||:|::|:.|..|...|.....|:.|.. :
Mouse   339 NLNRHIRGHMGIRPFQCTVCLKTFTAKSTLQDHLNIHSGDRPYKCHCCDMDFKHKSALKKHLTSV 403

  Fly   494 HERRGQSARESVA 506
            |   |:|:.|.::
Mouse   404 H---GRSSGEKLS 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4936	NP_650862.1	zf-AD	22..95	CDD:214871
		C2H2 Zn finger	362..382	CDD:275368	2/19 (11%)
		zf-H2C2_2	375..399	CDD:290200	6/23 (26%)
		COG5048	386..>447	CDD:227381	16/60 (27%)
		C2H2 Zn finger	390..410	CDD:275368	5/19 (26%)
		zf-H2C2_2	403..426	CDD:290200	5/22 (23%)
		C2H2 Zn finger	418..438	CDD:275368	6/19 (32%)
		zf-H2C2_2	432..455	CDD:290200	12/22 (55%)
		C2H2 Zn finger	446..466	CDD:275368	10/19 (53%)
		zf-H2C2_2	459..481	CDD:290200	8/21 (38%)
		C2H2 Zn finger	474..494	CDD:275368	5/20 (25%)
Zbtb6	NP_666365.1	BTB	23..123	CDD:279045	2/7 (29%)
		BTB	34..127	CDD:197585	2/11 (18%)
		C2H2 Zn finger	302..322	CDD:275368	5/19 (26%)
		zf-C2H2	325..347	CDD:278523	6/21 (29%)
		C2H2 Zn finger	327..347	CDD:275368	6/19 (32%)
		zf-H2C2_2	339..363	CDD:290200	11/23 (48%)
		C2H2 Zn finger	355..375	CDD:275368	10/19 (53%)
		C2H2 Zn finger	383..400	CDD:275368	4/16 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910