DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG4936 and Zfp12

DIOPT Version :9

Sequence 1:NP_650862.1 Gene:CG4936 / 42393 FlyBaseID:FBgn0038768 Length:521 Species:Drosophila melanogaster
Sequence 2:NP_001276518.1 Gene:Zfp12 / 231866 MGIID:99157 Length:686 Species:Mus musculus


Alignment Length:520 Identity:127/520 - (24%)
Similarity:205/520 - (39%) Gaps:118/520 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    73 FKVLKMAFK--------------FRETCQRSYGHL----RQFVGP---VEVEQRPPEKKGSE--- 113
            ||.:.:||.              :|:....:|.:|    ...:.|   :::||      |.|   
Mouse    10 FKDVAVAFSQEEWQQLDPEERTTYRDVMLETYSNLVSVGYDIIKPDVIIKLEQ------GEEPWI 68

  Fly   114 TATKLEPDVDPDEAE------QEPEHDEEDEDVDLDESHYAEADDAAETQGG---VFHDE----- 164
            ......|...|||..      :|.:..||::......|:.:.||.:::...|   .|..:     
Mouse    69 VEGAFSPQSYPDEIRHMSRLMEEDQGGEENQSSSAVFSYRSRADASSKATDGETKPFPSQKALPQ 133

  Fly   165 ---------------IEDGILVEL--------------EKDRIVHVKNEQVE------EDGIIEE 194
                           ..||...:|              .|....|...|..|      ||.:.||
Mouse   134 CNSCEKSLMCVSAFIRSDGSYAKLRPNVCAGCGKPLPCSKPEETHPGGESYEFSGDGDEDPLGEE 198

  Fly   195 VYDVYETYEGDLIPDQGYDHEMADQALSELSAEIEYLDQVEHDQLTESAHEDDAEV------DLN 253
              .||:  :|..: ::.:::....::..:.:..:.:|::       |....:||||      ||:
Mouse   199 --GVYQ--KGHFL-EEPFEYVECQKSFPKGTVFLNHLEE-------EPCDWNDAEVAFLQTSDLS 251

  Fly   254 STEEEFVPSKSVRASIHARNATKRRVNPRRSATSTASVAVE-SSTSKTTDRGNPLKVRRGNSDSA 317
            :.::..:..|........::..|:........|.|.....: |...|:..:...|.|.:  ....
Mouse   252 AHQDSLMEMKPYECQQCGKSFCKKSKFVIHQRTHTGEKPFKCSQCGKSFCQKGTLTVHQ--RTHT 314

  Fly   318 GSKMSIKSEKDISIGEVL-----ARKHSGIKT-KGGH-------KILLGDKK-----EFKYICDV 364
            |.|....:|...:..:.|     .|.|||.|. |.|:       |..|...:     |..|:|..
Mouse   315 GEKPYECTECGKTFYQKLHLIQHQRTHSGEKPYKCGYCGKSFCQKTHLTQHQRTHSGERPYVCHD 379

  Fly   365 CGNMYPSQSRLTEHIKVHSGVKPHECEICGHCFAQAQQLARHMNTHTGNRPYKCSYCPAAFADLS 429
            ||..:..:|.|.:|.|:|:|||.::|..||.||.:...|..||.||||.:||:|:.|...|:.||
Mouse   380 CGKTFSQKSALNDHQKIHTGVKLYKCSECGKCFCRKSTLTTHMRTHTGEKPYECNECGKFFSRLS 444

  Fly   430 TRNKHHRIHTNERPYECDVCHKTFTYTNTLKFHKMIHTGEKPHVCDVCGKGFPQAYKLRNHRVIH 494
            ....|:|.|:.|:||||..|.|:|...:.|..|:.:||||||:.|:.|||.|.|...|..|...|
Mouse   445 YLTVHYRTHSGEKPYECAECGKSFYLNSALMRHQRVHTGEKPYECNECGKLFSQLSYLTVHHRTH 509

  Fly   495  494
            Mouse   510  509

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG4936NP_650862.1 zf-AD 22..95 CDD:214871 7/39 (18%)
C2H2 Zn finger 362..382 CDD:275368 7/19 (37%)
zf-H2C2_2 375..399 CDD:290200 12/23 (52%)
COG5048 386..>447 CDD:227381 27/60 (45%)
C2H2 Zn finger 390..410 CDD:275368 8/19 (42%)
zf-H2C2_2 403..426 CDD:290200 11/22 (50%)
C2H2 Zn finger 418..438 CDD:275368 7/19 (37%)
zf-H2C2_2 432..455 CDD:290200 11/22 (50%)
C2H2 Zn finger 446..466 CDD:275368 6/19 (32%)
zf-H2C2_2 459..481 CDD:290200 12/21 (57%)
C2H2 Zn finger 474..494 CDD:275368 8/19 (42%)
Zfp12NP_001276518.1 C2H2 Zn finger 489..509 CDD:275368 8/19 (42%)
C2H2 Zn finger 517..537 CDD:275368
C2H2 Zn finger 545..565 CDD:275368
C2H2 Zn finger 573..593 CDD:275368
C2H2 Zn finger 601..621 CDD:275368
C2H2 Zn finger 629..649 CDD:275368
C2H2 Zn finger 657..677 CDD:275368
KRAB 8..68 CDD:214630 12/63 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 90..129 8/38 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 174..198 5/23 (22%)
COG5048 251..677 CDD:227381 81/261 (31%)
C2H2 Zn finger 265..285 CDD:275368 1/19 (5%)
C2H2 Zn finger 293..313 CDD:275368 4/21 (19%)
C2H2 Zn finger 321..341 CDD:275368 3/19 (16%)
C2H2 Zn finger 349..369 CDD:275368 3/19 (16%)
C2H2 Zn finger 377..397 CDD:275368 7/19 (37%)
C2H2 Zn finger 405..425 CDD:275368 8/19 (42%)
C2H2 Zn finger 433..453 CDD:275368 7/19 (37%)
C2H2 Zn finger 461..481 CDD:275368 6/19 (32%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
00.000

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